Topical bFGF Improves Secondary Lymphedema through Lymphangiogenesis in a Rat Tail Model
Identifieur interne : 002390 ( Main/Exploration ); précédent : 002389; suivant : 002391Topical bFGF Improves Secondary Lymphedema through Lymphangiogenesis in a Rat Tail Model
Auteurs : Tetsuro Onishi ; Takanobu Nishizuka ; Toshikazu Kurahashi ; Tetsuya Arai ; Katsuyuki Iwatsuki ; Michiro Yamamoto ; Hitoshi HirataSource :
- Plastic and Reconstructive Surgery Global Open [ 2169-7574 ] ; 2014.
Abstract
Secondary lymphedema is a common complication of cancer therapy, but options for treating lymphedema are essentially ineffective and limited. On the contrary, lymphangiogenic growth factors accelerate lymphangiogenesis and improve lymphedema.
Rat tail models of lymphedema were assigned to groups that received either daily topical basic fibroblast growth factor (bFGF) or saline (control) groups. Tail volume was measured, and the function of the lymphatic system was evaluated as the fluorescence intensity of indocyanine green every 3 days. The mRNA levels of vascular endothelial growth factor (VEGF)-C and VEGF-D and the protein levels of VEGF-C were evaluated at postoperative days (PODs) 7, 14, and 28. The subcutaneous and deep areas and lymphatic vessel density were histologically determined at PODs 7, 14, and 28.
Tail volume was significantly larger in the control than in the bFGF group (
Topical bFGF induces lymphangiogenesis and improves lymphedema in the rat tail model.
Url:
DOI: 10.1097/GOX.0000000000000154
PubMed: 25426379
PubMed Central: 4236357
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Topical bFGF Improves Secondary Lymphedema through Lymphangiogenesis in a Rat Tail Model</title><author><name sortKey="Onishi, Tetsuro" sort="Onishi, Tetsuro" uniqKey="Onishi T" first="Tetsuro" last="Onishi">Tetsuro Onishi</name></author><author><name sortKey="Nishizuka, Takanobu" sort="Nishizuka, Takanobu" uniqKey="Nishizuka T" first="Takanobu" last="Nishizuka">Takanobu Nishizuka</name></author><author><name sortKey="Kurahashi, Toshikazu" sort="Kurahashi, Toshikazu" uniqKey="Kurahashi T" first="Toshikazu" last="Kurahashi">Toshikazu Kurahashi</name></author><author><name sortKey="Arai, Tetsuya" sort="Arai, Tetsuya" uniqKey="Arai T" first="Tetsuya" last="Arai">Tetsuya Arai</name></author><author><name sortKey="Iwatsuki, Katsuyuki" sort="Iwatsuki, Katsuyuki" uniqKey="Iwatsuki K" first="Katsuyuki" last="Iwatsuki">Katsuyuki Iwatsuki</name></author><author><name sortKey="Yamamoto, Michiro" sort="Yamamoto, Michiro" uniqKey="Yamamoto M" first="Michiro" last="Yamamoto">Michiro Yamamoto</name></author><author><name sortKey="Hirata, Hitoshi" sort="Hirata, Hitoshi" uniqKey="Hirata H" first="Hitoshi" last="Hirata">Hitoshi Hirata</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25426379</idno><idno type="pmc">4236357</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236357</idno><idno type="RBID">PMC:4236357</idno><idno type="doi">10.1097/GOX.0000000000000154</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">004565</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004565</idno><idno type="wicri:Area/Pmc/Curation">004564</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004564</idno><idno type="wicri:Area/Pmc/Checkpoint">001674</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001674</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001187</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001187</idno><idno type="wicri:Area/PubMed/Curation">001187</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001187</idno><idno type="wicri:Area/PubMed/Checkpoint">001187</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001187</idno><idno type="wicri:Area/Ncbi/Merge">006D60</idno><idno type="wicri:Area/Ncbi/Curation">006D60</idno><idno type="wicri:Area/Ncbi/Checkpoint">006D60</idno><idno type="wicri:Area/Main/Merge">002393</idno><idno type="wicri:Area/Main/Curation">002390</idno><idno type="wicri:Area/Main/Exploration">002390</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Topical bFGF Improves Secondary Lymphedema through Lymphangiogenesis in a Rat Tail Model</title><author><name sortKey="Onishi, Tetsuro" sort="Onishi, Tetsuro" uniqKey="Onishi T" first="Tetsuro" last="Onishi">Tetsuro Onishi</name></author><author><name sortKey="Nishizuka, Takanobu" sort="Nishizuka, Takanobu" uniqKey="Nishizuka T" first="Takanobu" last="Nishizuka">Takanobu Nishizuka</name></author><author><name sortKey="Kurahashi, Toshikazu" sort="Kurahashi, Toshikazu" uniqKey="Kurahashi T" first="Toshikazu" last="Kurahashi">Toshikazu Kurahashi</name></author><author><name sortKey="Arai, Tetsuya" sort="Arai, Tetsuya" uniqKey="Arai T" first="Tetsuya" last="Arai">Tetsuya Arai</name></author><author><name sortKey="Iwatsuki, Katsuyuki" sort="Iwatsuki, Katsuyuki" uniqKey="Iwatsuki K" first="Katsuyuki" last="Iwatsuki">Katsuyuki Iwatsuki</name></author><author><name sortKey="Yamamoto, Michiro" sort="Yamamoto, Michiro" uniqKey="Yamamoto M" first="Michiro" last="Yamamoto">Michiro Yamamoto</name></author><author><name sortKey="Hirata, Hitoshi" sort="Hirata, Hitoshi" uniqKey="Hirata H" first="Hitoshi" last="Hirata">Hitoshi Hirata</name></author></analytic><series><title level="j">Plastic and Reconstructive Surgery Global Open</title><idno type="eISSN">2169-7574</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Secondary lymphedema is a common complication of cancer therapy, but options for treating lymphedema are essentially ineffective and limited. On the contrary, lymphangiogenic growth factors accelerate lymphangiogenesis and improve lymphedema.</p></sec><sec><title>Methods:</title><p>Rat tail models of lymphedema were assigned to groups that received either daily topical basic fibroblast growth factor (bFGF) or saline (control) groups. Tail volume was measured, and the function of the lymphatic system was evaluated as the fluorescence intensity of indocyanine green every 3 days. The mRNA levels of vascular endothelial growth factor (VEGF)-C and VEGF-D and the protein levels of VEGF-C were evaluated at postoperative days (PODs) 7, 14, and 28. The subcutaneous and deep areas and lymphatic vessel density were histologically determined at PODs 7, 14, and 28.</p></sec><sec><title>Results:</title><p>Tail volume was significantly larger in the control than in the bFGF group (<italic>P</italic> < 0.05). The intensity of indocyanine green fluorescence significantly decreased earlier in the bFGF group (<italic>P</italic> < 0.05). The mRNA and protein levels of VEGF-C were upregulated in the bFGF group at POD 14 (<italic>P</italic> < 0.01). Both subcutaneous and deep tissues gradually withered in both groups but more rapidly in the bFGF, than in the control group, reaching statistically significant differences in the subcutaneous and deeper areas at POD 14 (<italic>P</italic> < 0.05). Lymphatic vessel density was significantly higher in the bFGF than in the control group at POD 14 (<italic>P</italic> < 0.05).</p></sec><sec><title>Conclusions:</title><p>Topical bFGF induces lymphangiogenesis and improves lymphedema in the rat tail model.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Witte, Mh" uniqKey="Witte M">MH Witte</name></author><author><name sortKey="Bernas, Mj" uniqKey="Bernas M">MJ Bernas</name></author><author><name sortKey="Martin, Cp" uniqKey="Martin C">CP Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oliver, G" uniqKey="Oliver G">G Oliver</name></author><author><name sortKey="Detmar, M" uniqKey="Detmar M">M Detmar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name 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Tsunoda</name></author><author><name sortKey="Nakamura, T" uniqKey="Nakamura T">T Nakamura</name></author><author><name sortKey="Sakurai, H" uniqKey="Sakurai H">H Sakurai</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Arai, Tetsuya" sort="Arai, Tetsuya" uniqKey="Arai T" first="Tetsuya" last="Arai">Tetsuya Arai</name><name sortKey="Hirata, Hitoshi" sort="Hirata, Hitoshi" uniqKey="Hirata H" first="Hitoshi" last="Hirata">Hitoshi Hirata</name><name sortKey="Iwatsuki, Katsuyuki" sort="Iwatsuki, Katsuyuki" uniqKey="Iwatsuki K" first="Katsuyuki" last="Iwatsuki">Katsuyuki Iwatsuki</name><name sortKey="Kurahashi, Toshikazu" sort="Kurahashi, Toshikazu" uniqKey="Kurahashi T" first="Toshikazu" last="Kurahashi">Toshikazu Kurahashi</name><name sortKey="Nishizuka, Takanobu" sort="Nishizuka, Takanobu" uniqKey="Nishizuka T" first="Takanobu" last="Nishizuka">Takanobu Nishizuka</name><name sortKey="Onishi, Tetsuro" sort="Onishi, Tetsuro" uniqKey="Onishi T" first="Tetsuro" last="Onishi">Tetsuro Onishi</name><name sortKey="Yamamoto, Michiro" sort="Yamamoto, Michiro" uniqKey="Yamamoto M" first="Michiro" last="Yamamoto">Michiro Yamamoto</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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