LymphedemaV1, Main, Exploration, bibRecord, 001B61

Lymphatic vessel development: fluid flow and valve-forming cells

Identifieur interne : 001B61 ( Main/Exploration ); précédent : 001B60; suivant : 001B62

Lymphatic vessel development: fluid flow and valve-forming cells

Auteurs : Tsutomu Kume

Source :

The Journal of Clinical Investigation [ 0021-9738 ] ; 2015.

RBID : PMC:4563766

Descripteurs français

KwdFr :
- Animaux, Facteur de transcription GATA-2 (métabolisme), Humains, Lymphe (physiologie), Lymphoedème (embryologie), Muscles lisses vasculaires (embryologie), Mutation, Myocytes du muscle lisse (métabolisme), Vaisseaux lymphatiques (embryologie).
MESH :
- embryologie : Lymphoedème, Muscles lisses vasculaires, Vaisseaux lymphatiques.
- métabolisme : Facteur de transcription GATA-2, Myocytes du muscle lisse.
- physiologie : Lymphe.
- Animaux, Humains, Mutation.

English descriptors

KwdEn :
- Animals, GATA2 Transcription Factor (metabolism), Humans, Lymph (physiology), Lymphatic Vessels (embryology), Lymphedema (embryology), Muscle, Smooth, Vascular (embryology), Mutation, Myocytes, Smooth Muscle (metabolism).
MESH :
- chemical , metabolism : GATA2 Transcription Factor.
- embryology : Lymphatic Vessels, Lymphedema, Muscle, Smooth, Vascular.
- metabolism : Myocytes, Smooth Muscle.
- physiology : Lymph.
- Animals, Humans, Mutation.

Abstract

Hemodynamic forces regulate many aspects of blood vessel disease and development, including susceptibility to atherosclerosis and remodeling of primary blood vessels into a mature vascular network. Vessels of the lymphatic circulatory system are also subjected to fluid flow–associated forces, but the molecular and cellular mechanisms by which these forces regulate the formation and maintenance of lymphatic vessels remain largely uncharacterized. This issue of the JCI includes two articles that begin to address how fluid flow influences lymphatic vessel development and function. Sweet et al. demonstrate that lymph flow is essential for the remodeling of primary lymphatic vessels, for ensuring the proper distribution of smooth muscle cells (SMCs), and for the development and maturation of lymphatic valves. Kazenwadel et al. show that flow-induced lymphatic valve development is initiated by the upregulation of GATA2, which has been linked to lymphedema in patients with Emberger syndrome. Together, these observations and future studies inspired by these results have potential to lead to the development of strategies for the treatment of lymphatic disorders.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563766

DOI: 10.1172/JCI83189
PubMed: 26214518
PubMed Central: 4563766

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphatic vessel development: fluid flow and valve-forming cells</title>
<author><name sortKey="Kume, Tsutomu" sort="Kume, Tsutomu" uniqKey="Kume T" first="Tsutomu" last="Kume">Tsutomu Kume</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26214518</idno>
<idno type="pmc">4563766</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563766</idno>
<idno type="RBID">PMC:4563766</idno>
<idno type="doi">10.1172/JCI83189</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000137</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000137</idno>
<idno type="wicri:Area/Pmc/Curation">000137</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000137</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001106</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001106</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000D51</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D51</idno>
<idno type="wicri:Area/PubMed/Curation">000D51</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D51</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000D51</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D51</idno>
<idno type="wicri:Area/Ncbi/Merge">007668</idno>
<idno type="wicri:Area/Ncbi/Curation">007668</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">007668</idno>
<idno type="wicri:doubleKey">0021-9738:2015:Kume T:lymphatic:vessel:development</idno>
<idno type="wicri:Area/Main/Merge">001B64</idno>
<idno type="wicri:Area/Main/Curation">001B61</idno>
<idno type="wicri:Area/Main/Exploration">001B61</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lymphatic vessel development: fluid flow and valve-forming cells</title>
<author><name sortKey="Kume, Tsutomu" sort="Kume, Tsutomu" uniqKey="Kume T" first="Tsutomu" last="Kume">Tsutomu Kume</name>
</author>
</analytic>
<series><title level="j">The Journal of Clinical Investigation</title>
<idno type="ISSN">0021-9738</idno>
<idno type="eISSN">1558-8238</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>GATA2 Transcription Factor (metabolism)</term>
<term>Humans</term>
<term>Lymph (physiology)</term>
<term>Lymphatic Vessels (embryology)</term>
<term>Lymphedema (embryology)</term>
<term>Muscle, Smooth, Vascular (embryology)</term>
<term>Mutation</term>
<term>Myocytes, Smooth Muscle (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Facteur de transcription GATA-2 (métabolisme)</term>
<term>Humains</term>
<term>Lymphe (physiologie)</term>
<term>Lymphoedème (embryologie)</term>
<term>Muscles lisses vasculaires (embryologie)</term>
<term>Mutation</term>
<term>Myocytes du muscle lisse (métabolisme)</term>
<term>Vaisseaux lymphatiques (embryologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>GATA2 Transcription Factor</term>
</keywords>
<keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Lymphoedème</term>
<term>Muscles lisses vasculaires</term>
<term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic Vessels</term>
<term>Lymphedema</term>
<term>Muscle, Smooth, Vascular</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Myocytes, Smooth Muscle</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de transcription GATA-2</term>
<term>Myocytes du muscle lisse</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphe</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymph</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Mutation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Humains</term>
<term>Mutation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Hemodynamic forces regulate many aspects of blood vessel disease and development, including susceptibility to atherosclerosis and remodeling of primary blood vessels into a mature vascular network. Vessels of the lymphatic circulatory system are also subjected to fluid flow–associated forces, but the molecular and cellular mechanisms by which these forces regulate the formation and maintenance of lymphatic vessels remain largely uncharacterized. This issue of the <italic>JCI</italic>
 includes two articles that begin to address how fluid flow influences lymphatic vessel development and function. Sweet et al. demonstrate that lymph flow is essential for the remodeling of primary lymphatic vessels, for ensuring the proper distribution of smooth muscle cells (SMCs), and for the development and maturation of lymphatic valves. Kazenwadel et al. show that flow-induced lymphatic valve development is initiated by the upregulation of <italic>GATA2</italic>
, which has been linked to lymphedema in patients with Emberger syndrome. Together, these observations and future studies inspired by these results have potential to lead to the development of strategies for the treatment of lymphatic disorders.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Kume, Tsutomu" sort="Kume, Tsutomu" uniqKey="Kume T" first="Tsutomu" last="Kume">Tsutomu Kume</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B61 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001B61 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4563766
   |texte=   Lymphatic vessel development: fluid flow and valve-forming cells
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:26214518" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

Serveur d'exploration sur le lymphœdème

Lymphatic vessel development: fluid flow and valve-forming cells

Lymphatic vessel development: fluid flow and valve-forming cells

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.