Lymphatic vessel development: fluid flow and valve-forming cells
Identifieur interne : 000137 ( Pmc/Corpus ); précédent : 000136; suivant : 000138Lymphatic vessel development: fluid flow and valve-forming cells
Auteurs : Tsutomu KumeSource :
- The Journal of Clinical Investigation [ 0021-9738 ] ; 2015.
Abstract
Hemodynamic forces regulate many aspects of blood vessel disease and development, including susceptibility to atherosclerosis and remodeling of primary blood vessels into a mature vascular network. Vessels of the lymphatic circulatory system are also subjected to fluid flow–associated forces, but the molecular and cellular mechanisms by which these forces regulate the formation and maintenance of lymphatic vessels remain largely uncharacterized. This issue of the
Url:
DOI: 10.1172/JCI83189
PubMed: 26214518
PubMed Central: 4563766
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PMC:4563766Le document en format XML
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<series><title level="j">The Journal of Clinical Investigation</title>
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<front><div type="abstract" xml:lang="en"><p>Hemodynamic forces regulate many aspects of blood vessel disease and development, including susceptibility to atherosclerosis and remodeling of primary blood vessels into a mature vascular network. Vessels of the lymphatic circulatory system are also subjected to fluid flow–associated forces, but the molecular and cellular mechanisms by which these forces regulate the formation and maintenance of lymphatic vessels remain largely uncharacterized. This issue of the <italic>JCI</italic>
includes two articles that begin to address how fluid flow influences lymphatic vessel development and function. Sweet et al. demonstrate that lymph flow is essential for the remodeling of primary lymphatic vessels, for ensuring the proper distribution of smooth muscle cells (SMCs), and for the development and maturation of lymphatic valves. Kazenwadel et al. show that flow-induced lymphatic valve development is initiated by the upregulation of <italic>GATA2</italic>
, which has been linked to lymphedema in patients with Emberger syndrome. Together, these observations and future studies inspired by these results have potential to lead to the development of strategies for the treatment of lymphatic disorders.</p>
</div>
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<pmc article-type="article-commentary"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Invest</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Clin. Invest</journal-id>
<journal-id journal-id-type="publisher-id">J Clin Invest</journal-id>
<journal-title-group><journal-title>The Journal of Clinical Investigation</journal-title>
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<issn pub-type="ppub">0021-9738</issn>
<issn pub-type="epub">1558-8238</issn>
<publisher><publisher-name>American Society for Clinical Investigation</publisher-name>
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<article-id pub-id-type="publisher-id">83189</article-id>
<article-id pub-id-type="doi">10.1172/JCI83189</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Commentary</subject>
</subj-group>
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<title-group><article-title>Lymphatic vessel development: fluid flow and valve-forming cells</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Kume</surname>
<given-names>Tsutomu</given-names>
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<aff>Feinberg Cardiovascular Research Institute, Department of Medicine, Northwestern University School of Medicine, Chicago, Illinois, USA.</aff>
<author-notes><corresp>Address correspondence to: Tsutomu Kume, Feinberg Cardiovascular Research Institute, Department of Medicine, Northwestern University School of Medicine, 303 E Chicago Ave., Chicago, Illinois 60611, USA. E-mail: <email>t-kume@northwestern.edu</email>
.</corresp>
</author-notes>
<pub-date pub-type="epub"><day>27</day>
<month>7</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><day>3</day>
<month>8</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>3</day>
<month>8</month>
<year>2016</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and
0 days and was based on the . </pmc-comment>
<volume>125</volume>
<issue>8</issue>
<fpage>2924</fpage>
<lpage>2926</lpage>
<permissions><copyright-statement>Copyright © 2015, American Society for Clinical Investigation</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>American Society for Clinical Investigation</copyright-holder>
</permissions>
<abstract><p>Hemodynamic forces regulate many aspects of blood vessel disease and development, including susceptibility to atherosclerosis and remodeling of primary blood vessels into a mature vascular network. Vessels of the lymphatic circulatory system are also subjected to fluid flow–associated forces, but the molecular and cellular mechanisms by which these forces regulate the formation and maintenance of lymphatic vessels remain largely uncharacterized. This issue of the <italic>JCI</italic>
includes two articles that begin to address how fluid flow influences lymphatic vessel development and function. Sweet et al. demonstrate that lymph flow is essential for the remodeling of primary lymphatic vessels, for ensuring the proper distribution of smooth muscle cells (SMCs), and for the development and maturation of lymphatic valves. Kazenwadel et al. show that flow-induced lymphatic valve development is initiated by the upregulation of <italic>GATA2</italic>
, which has been linked to lymphedema in patients with Emberger syndrome. Together, these observations and future studies inspired by these results have potential to lead to the development of strategies for the treatment of lymphatic disorders.</p>
</abstract>
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