Lymphatic vessel development: fluid flow and valve-forming cells
Identifieur interne : 001B61 ( Main/Curation ); précédent : 001B60; suivant : 001B62Lymphatic vessel development: fluid flow and valve-forming cells
Auteurs : Tsutomu KumeSource :
- The Journal of Clinical Investigation [ 0021-9738 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- embryologie : Lymphoedème, Muscles lisses vasculaires, Vaisseaux lymphatiques.
- métabolisme : Facteur de transcription GATA-2, Myocytes du muscle lisse.
- physiologie : Lymphe.
- Animaux, Humains, Mutation.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : GATA2 Transcription Factor.
- embryology : Lymphatic Vessels, Lymphedema, Muscle, Smooth, Vascular.
- metabolism : Myocytes, Smooth Muscle.
- physiology : Lymph.
- Animals, Humans, Mutation.
Abstract
Hemodynamic forces regulate many aspects of blood vessel disease and development, including susceptibility to atherosclerosis and remodeling of primary blood vessels into a mature vascular network. Vessels of the lymphatic circulatory system are also subjected to fluid flow–associated forces, but the molecular and cellular mechanisms by which these forces regulate the formation and maintenance of lymphatic vessels remain largely uncharacterized. This issue of the
Url:
DOI: 10.1172/JCI83189
PubMed: 26214518
PubMed Central: 4563766
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PMC:4563766Le document en format XML
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<series><title level="j">The Journal of Clinical Investigation</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>GATA2 Transcription Factor (metabolism)</term>
<term>Humans</term>
<term>Lymph (physiology)</term>
<term>Lymphatic Vessels (embryology)</term>
<term>Lymphedema (embryology)</term>
<term>Muscle, Smooth, Vascular (embryology)</term>
<term>Mutation</term>
<term>Myocytes, Smooth Muscle (metabolism)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Facteur de transcription GATA-2 (métabolisme)</term>
<term>Humains</term>
<term>Lymphe (physiologie)</term>
<term>Lymphoedème (embryologie)</term>
<term>Muscles lisses vasculaires (embryologie)</term>
<term>Mutation</term>
<term>Myocytes du muscle lisse (métabolisme)</term>
<term>Vaisseaux lymphatiques (embryologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>GATA2 Transcription Factor</term>
</keywords>
<keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Lymphoedème</term>
<term>Muscles lisses vasculaires</term>
<term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic Vessels</term>
<term>Lymphedema</term>
<term>Muscle, Smooth, Vascular</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Myocytes, Smooth Muscle</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de transcription GATA-2</term>
<term>Myocytes du muscle lisse</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphe</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymph</term>
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<term>Humans</term>
<term>Mutation</term>
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<front><div type="abstract" xml:lang="en"><p>Hemodynamic forces regulate many aspects of blood vessel disease and development, including susceptibility to atherosclerosis and remodeling of primary blood vessels into a mature vascular network. Vessels of the lymphatic circulatory system are also subjected to fluid flow–associated forces, but the molecular and cellular mechanisms by which these forces regulate the formation and maintenance of lymphatic vessels remain largely uncharacterized. This issue of the <italic>JCI</italic>
includes two articles that begin to address how fluid flow influences lymphatic vessel development and function. Sweet et al. demonstrate that lymph flow is essential for the remodeling of primary lymphatic vessels, for ensuring the proper distribution of smooth muscle cells (SMCs), and for the development and maturation of lymphatic valves. Kazenwadel et al. show that flow-induced lymphatic valve development is initiated by the upregulation of <italic>GATA2</italic>
, which has been linked to lymphedema in patients with Emberger syndrome. Together, these observations and future studies inspired by these results have potential to lead to the development of strategies for the treatment of lymphatic disorders.</p>
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