Duration of detection of anti-BmR1 IgG4 antibodies after mass-drug administration (MDA) in Sarawak, Malaysia.
Identifieur interne : 004361 ( Main/Curation ); précédent : 004360; suivant : 004362Duration of detection of anti-BmR1 IgG4 antibodies after mass-drug administration (MDA) in Sarawak, Malaysia.
Auteurs : R. Noordin [Malaisie] ; J. Muhi ; Z. Md Idris ; N. Arifin ; A. KiyuSource :
- Tropical biomedicine [ 0127-5720 ] ; 2012.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe, Brugia (immunologie), Enfant, Enfant d'âge préscolaire, Facteurs temps, Filaricides (administration et posologie), Filariose lymphatique (immunologie), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Humains, Immunoglobuline G (sang), Jeune adulte, Malaisie (épidémiologie), Mâle, Protéines recombinantes, Sujet âgé, Sujet âgé de 80 ans ou plus, Traitement médicamenteux (), Études séroépidémiologiques.
- MESH :
- administration et posologie : Filaricides.
- immunologie : Brugia, Filariose lymphatique.
- sang : Anticorps antihelminthe, Immunoglobuline G.
- traitement médicamenteux : Filariose lymphatique.
- épidémiologie : Filariose lymphatique, Malaisie.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Antigènes d'helminthe, Enfant, Enfant d'âge préscolaire, Facteurs temps, Humains, Jeune adulte, Mâle, Protéines recombinantes, Sujet âgé, Sujet âgé de 80 ans ou plus, Traitement médicamenteux, Études séroépidémiologiques.
- Wicri :
- geographic : Malaisie.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Antibodies, Helminth (blood), Antigens, Helminth, Brugia (immunology), Child, Child, Preschool, Drug Therapy (methods), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Filaricides (administration & dosage), Humans, Immunoglobulin G (blood), Malaysia (epidemiology), Male, Middle Aged, Recombinant Proteins, Seroepidemiologic Studies, Time Factors, Young Adult.
- MESH :
- chemical , administration & dosage : Filaricides.
- chemical , blood : Antibodies, Helminth, Immunoglobulin G.
- geographic , epidemiology : Malaysia.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- immunology : Brugia, Elephantiasis, Filarial.
- methods : Drug Therapy.
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Antigens, Helminth, Child, Child, Preschool, Humans, Male, Middle Aged, Recombinant Proteins, Seroepidemiologic Studies, Time Factors, Young Adult.
Abstract
The detection rates of brugian filariasis in three regions of Sarawak namely Central, North and South after three courses of mass drug administration (MDA) from year 2004 to 2006 was investigated. A recombinant BmR1 antigen-based IgG4 detection test, named Brugia Rapid and night blood smear for microfilaria (mf) detection were used. All three regions recorded a sharp fall in mf positive rates after a year post-MDA. Meanwhile Brugia Rapid positive rates declined more gradually to 3.8% and 5.6% of the pre-MDA levels in the Central and North regions, respectively. This study showed that in filariasis endemic areas in Sarawak, anti-filarial IgG4 antibodies to BmR1, as detected by the Brugia Rapid test, were positive for one to two years after mf disappearance.
PubMed: 22543621
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pubmed:22543621Le document en format XML
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<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Animals</term>
<term>Antibodies, Helminth (blood)</term>
<term>Antigens, Helminth</term>
<term>Brugia (immunology)</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Drug Therapy (methods)</term>
<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Elephantiasis, Filarial (epidemiology)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Filaricides (administration & dosage)</term>
<term>Humans</term>
<term>Immunoglobulin G (blood)</term>
<term>Malaysia (epidemiology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Recombinant Proteins</term>
<term>Seroepidemiologic Studies</term>
<term>Time Factors</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Anticorps antihelminthe (sang)</term>
<term>Antigènes d'helminthe</term>
<term>Brugia (immunologie)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Facteurs temps</term>
<term>Filaricides (administration et posologie)</term>
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<term>Filariose lymphatique (traitement médicamenteux)</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term>
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<term>Elephantiasis, Filarial</term>
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<term>Immunoglobuline G</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term>
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<term>Antigens, Helminth</term>
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<term>Child, Preschool</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Recombinant Proteins</term>
<term>Seroepidemiologic Studies</term>
<term>Time Factors</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Antigènes d'helminthe</term>
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<term>Enfant d'âge préscolaire</term>
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<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Protéines recombinantes</term>
<term>Sujet âgé</term>
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<front><div type="abstract" xml:lang="en">The detection rates of brugian filariasis in three regions of Sarawak namely Central, North and South after three courses of mass drug administration (MDA) from year 2004 to 2006 was investigated. A recombinant BmR1 antigen-based IgG4 detection test, named Brugia Rapid and night blood smear for microfilaria (mf) detection were used. All three regions recorded a sharp fall in mf positive rates after a year post-MDA. Meanwhile Brugia Rapid positive rates declined more gradually to 3.8% and 5.6% of the pre-MDA levels in the Central and North regions, respectively. This study showed that in filariasis endemic areas in Sarawak, anti-filarial IgG4 antibodies to BmR1, as detected by the Brugia Rapid test, were positive for one to two years after mf disappearance.</div>
</front>
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