Evaluation of the role of human β-defensin 3 in modulation of immunity and inflammatory response after knee replacement
Identifieur interne : 000573 ( Main/Curation ); précédent : 000572; suivant : 000574Evaluation of the role of human β-defensin 3 in modulation of immunity and inflammatory response after knee replacement
Auteurs : Jiguang Jia [République populaire de Chine] ; Hao Peng [République populaire de Chine] ; Sen Chen [République populaire de Chine]Source :
- Experimental and Therapeutic Medicine [ 1792-0981 ] ; 2017.
Abstract
The present study investigated the value of human β-defensin 3 (HBD-3) in adjusting the immunity and inflammatory response of T lymphocytes in the body after knee replacement. Sixty-four cases of knee replacement patients were successively selected and randomly divided into the control group and the observation group each with 32 cases. Once a day, for 7 days, patients in the control group were injected with placebo saline solution in the articular cavity. Levels of Th1 and/Th2, interleukin (IL)-2 and IL-10, tumor necrosis factor (TNF)-α, toll-like receptor (TLR)-4, and alkaline phosphatase (ALP) were compared one month later, and implant infection rates were compared within 1-year follow-up. Compared with patients in the control group, the levels of Th1 and Th1/Th2 in the observation group significantly increased, yet their Th2 decreased. The levels of IL-2 and TNF-α were also observed to be significantly elevated, yet IL-10 decreased. Furthermore, their TLR-4 and ALP levels were significantly higher. Three cases of implant-related infection occurred in the control group and 1 case in the observation group. In conclusion, HBD-3 could adjust the immunity and inflammatory response of cells in the body after knee replacement, possibly playing an important role in implant-related infection.
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DOI: 10.3892/etm.2017.4100
PubMed: 28413475
PubMed Central: 5377263
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060</wicri:regionArea><wicri:noRegion>Hubei 430060</wicri:noRegion></affiliation></author><author><name sortKey="Peng, Hao" sort="Peng, Hao" uniqKey="Peng H" first="Hao" last="Peng">Hao Peng</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-4100">Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060</wicri:regionArea><wicri:noRegion>Hubei 430060</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Sen" sort="Chen, Sen" uniqKey="Chen S" first="Sen" last="Chen">Sen Chen</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-4100">Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. 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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060</wicri:regionArea><wicri:noRegion>Hubei 430060</wicri:noRegion></affiliation></author><author><name sortKey="Peng, Hao" sort="Peng, Hao" uniqKey="Peng H" first="Hao" last="Peng">Hao Peng</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-4100">Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060</wicri:regionArea><wicri:noRegion>Hubei 430060</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Sen" sort="Chen, Sen" uniqKey="Chen S" first="Sen" last="Chen">Sen Chen</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-4100">Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060</wicri:regionArea><wicri:noRegion>Hubei 430060</wicri:noRegion></affiliation></author></analytic><series><title level="j">Experimental and Therapeutic Medicine</title><idno type="ISSN">1792-0981</idno><idno type="eISSN">1792-1015</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The present study investigated the value of human β-defensin 3 (HBD-3) in adjusting the immunity and inflammatory response of T lymphocytes in the body after knee replacement. Sixty-four cases of knee replacement patients were successively selected and randomly divided into the control group and the observation group each with 32 cases. Once a day, for 7 days, patients in the control group were injected with placebo saline solution in the articular cavity. Levels of Th1 and/Th2, interleukin (IL)-2 and IL-10, tumor necrosis factor (TNF)-α, toll-like receptor (TLR)-4, and alkaline phosphatase (ALP) were compared one month later, and implant infection rates were compared within 1-year follow-up. Compared with patients in the control group, the levels of Th1 and Th1/Th2 in the observation group significantly increased, yet their Th2 decreased. The levels of IL-2 and TNF-α were also observed to be significantly elevated, yet IL-10 decreased. Furthermore, their TLR-4 and ALP levels were significantly higher. Three cases of implant-related infection occurred in the control group and 1 case in the observation group. In conclusion, HBD-3 could adjust the immunity and inflammatory response of cells in the body after knee replacement, possibly playing an important role in implant-related infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Saksena, J" uniqKey="Saksena J">J Saksena</name></author><author><name sortKey="Platts, Ad" uniqKey="Platts A">AD Platts</name></author><author><name sortKey="Dowd, Gs" uniqKey="Dowd G">GS Dowd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Mw" uniqKey="Zhao M">MW Zhao</name></author><author><name sortKey="Tian, H" uniqKey="Tian H">H Tian</name></author><author><name sortKey="Zeng, L" uniqKey="Zeng L">L Zeng</name></author><author><name sortKey="Li, Bg" uniqKey="Li B">BG Li</name></author><author><name sortKey="Zhang, Fl" uniqKey="Zhang F">FL Zhang</name></author><author><name sortKey="Li, Ly" uniqKey="Li L">LY Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanchanabat, B" uniqKey="Kanchanabat B">B Kanchanabat</name></author><author><name sortKey="Stapanavatr, W" uniqKey="Stapanavatr W">W Stapanavatr</name></author><author><name sortKey="Meknavin, S" uniqKey="Meknavin S">S Meknavin</name></author><author><name sortKey="Soorapanth, C" uniqKey="Soorapanth C">C Soorapanth</name></author><author><name sortKey="Sumanasrethakul, C" uniqKey="Sumanasrethakul C">C Sumanasrethakul</name></author><author><name sortKey="Kanchanasuttirak, P" uniqKey="Kanchanasuttirak P">P Kanchanasuttirak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huizinga, Mr" uniqKey="Huizinga M">MR Huizinga</name></author><author><name sortKey="Brouwer, Rw" uniqKey="Brouwer R">RW Brouwer</name></author><author><name sortKey="Bisschop, R" uniqKey="Bisschop R">R Bisschop</name></author><author><name sortKey="Van Der Veen, Hc" uniqKey="Van Der Veen H">HC van der Veen</name></author><author><name sortKey="Van Den Akker Scheek, I" uniqKey="Van Den Akker Scheek I">I van den Akker-Scheek</name></author><author><name sortKey="Van Raay, Jj" uniqKey="Van Raay J">JJ van Raay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schrama, Jc" uniqKey="Schrama J">JC Schrama</name></author><author><name sortKey="Espehaug, B" uniqKey="Espehaug B">B Espehaug</name></author><author><name sortKey="Hallan, G" uniqKey="Hallan G">G Hallan</name></author><author><name sortKey="Engesaeter, Lb" uniqKey="Engesaeter L">LB Engesaeter</name></author><author><name sortKey="Furnes, O" uniqKey="Furnes O">O Furnes</name></author><author><name sortKey="Havelin, Li" uniqKey="Havelin L">LI Havelin</name></author><author><name sortKey="Fevang, Bt" uniqKey="Fevang B">BT Fevang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Montanaro, L" uniqKey="Montanaro L">L Montanaro</name></author><author><name sortKey="Speziale, P" uniqKey="Speziale P">P Speziale</name></author><author><name sortKey="Campoccia, D" uniqKey="Campoccia D">D Campoccia</name></author><author><name sortKey="Ravaioli, S" uniqKey="Ravaioli S">S Ravaioli</name></author><author><name sortKey="Cangini, I" uniqKey="Cangini I">I Cangini</name></author><author><name sortKey="Pietrocola, G" uniqKey="Pietrocola G">G Pietrocola</name></author><author><name sortKey="Giannini, S" uniqKey="Giannini S">S Giannini</name></author><author><name sortKey="Arciola, Cr" uniqKey="Arciola C">CR Arciola</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ning, R" uniqKey="Ning R">R Ning</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Guo, X" uniqKey="Guo X">X Guo</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jarczak, J" uniqKey="Jarczak J">J Jarczak</name></author><author><name sortKey="Ko Ciuczuk, Em" uniqKey="Ko Ciuczuk E">EM Kościuczuk</name></author><author><name sortKey="Lisowski, P" uniqKey="Lisowski P">P Lisowski</name></author><author><name sortKey="Strzalkowska, N" uniqKey="Strzalkowska N">N Strzałkowska</name></author><author><name sortKey="J Wik, A" uniqKey="J Wik A">A Jóźwik</name></author><author><name sortKey="Horba Czuk, J" uniqKey="Horba Czuk J">J Horbańczuk</name></author><author><name sortKey="Krzy Ewski, J" uniqKey="Krzy Ewski J">J Krzyżewski</name></author><author><name sortKey="Zwierzchowski, L" uniqKey="Zwierzchowski L">L Zwierzchowski</name></author><author><name sortKey="Bagnicka, E" uniqKey="Bagnicka E">E Bagnicka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Batoni, G" uniqKey="Batoni G">G Batoni</name></author><author><name sortKey="Maisetta, G" uniqKey="Maisetta G">G Maisetta</name></author><author><name sortKey="Esin, S" uniqKey="Esin S">S Esin</name></author><author><name sortKey="Campa, M" uniqKey="Campa M">M Campa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hinrichsen, K" uniqKey="Hinrichsen K">K Hinrichsen</name></author><author><name sortKey="Podschun, R" uniqKey="Podschun R">R Podschun</name></author><author><name sortKey="Schubert, S" uniqKey="Schubert S">S Schubert</name></author><author><name sortKey="Schroder, Jm" uniqKey="Schroder J">JM Schröder</name></author><author><name sortKey="Harder, J" uniqKey="Harder J">J Harder</name></author><author><name sortKey="Proksch, E" uniqKey="Proksch E">E Proksch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Yp" uniqKey="Chen Y">YP Chen</name></author><author><name sortKey="Wu, Cc" uniqKey="Wu C">CC Wu</name></author><author><name sortKey="Ho, Wp" uniqKey="Ho W">WP Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiang, Er" uniqKey="Chiang E">ER Chiang</name></author><author><name sortKey="Su, Yp" uniqKey="Su Y">YP Su</name></author><author><name sortKey="Chen, Th" uniqKey="Chen T">TH Chen</name></author><author><name sortKey="Chiu, Fy" uniqKey="Chiu F">FY Chiu</name></author><author><name sortKey="Chen, Wm" uniqKey="Chen W">WM Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilarranz, R" uniqKey="Gilarranz R">R Gilarranz</name></author><author><name sortKey="Chamizo, F" uniqKey="Chamizo F">F Chamizo</name></author><author><name sortKey="Horcajada, I" uniqKey="Horcajada I">I Horcajada</name></author><author><name sortKey="Bordes Benitez, A" uniqKey="Bordes Benitez A">A Bordes-Benítez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, Pk" uniqKey="Singh P">PK Singh</name></author><author><name sortKey="Shiha, Mj" uniqKey="Shiha M">MJ Shiha</name></author><author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colavita, I" uniqKey="Colavita I">I Colavita</name></author><author><name sortKey="Nigro, E" uniqKey="Nigro E">E Nigro</name></author><author><name sortKey="Sarnataro, D" uniqKey="Sarnataro D">D Sarnataro</name></author><author><name sortKey="Scudiero, O" uniqKey="Scudiero O">O Scudiero</name></author><author><name sortKey="Granata, V" uniqKey="Granata V">V Granata</name></author><author><name sortKey="Daniele, A" uniqKey="Daniele A">A Daniele</name></author><author><name sortKey="Zagari, A" uniqKey="Zagari A">A Zagari</name></author><author><name sortKey="Pessi, A" uniqKey="Pessi A">A Pessi</name></author><author><name sortKey="Salvatore, F" uniqKey="Salvatore F">F Salvatore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bedran, Tb" uniqKey="Bedran T">TB Bedran</name></author><author><name sortKey="Mayer, Mp" uniqKey="Mayer M">MP Mayer</name></author><author><name sortKey="Spolidorio, Dp" uniqKey="Spolidorio D">DP Spolidorio</name></author><author><name sortKey="Grenier, D" uniqKey="Grenier D">D Grenier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Warnke, Ph" uniqKey="Warnke P">PH Warnke</name></author><author><name sortKey="Springer, In" uniqKey="Springer I">IN Springer</name></author><author><name sortKey="Russo, Pa" uniqKey="Russo P">PA Russo</name></author><author><name sortKey="Wiltfang, J" uniqKey="Wiltfang J">J Wiltfang</name></author><author><name sortKey="Essig, H" uniqKey="Essig H">H Essig</name></author><author><name sortKey="Kosmahl, M" uniqKey="Kosmahl M">M Kosmahl</name></author><author><name sortKey="Sherry, E" uniqKey="Sherry E">E Sherry</name></author><author><name sortKey="Acil, Y" uniqKey="Acil Y">Y Acil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varoga, D" uniqKey="Varoga D">D Varoga</name></author><author><name 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sortKey="Mu Oz, E" uniqKey="Mu Oz E">E Muñoz</name></author><author><name sortKey="G Mez, A" uniqKey="G Mez A">A Gómez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Semple, F" uniqKey="Semple F">F Semple</name></author><author><name sortKey="Macpherson, H" uniqKey="Macpherson H">H MacPherson</name></author><author><name sortKey="Webb, S" uniqKey="Webb S">S Webb</name></author><author><name sortKey="Cox, Sl" uniqKey="Cox S">SL Cox</name></author><author><name sortKey="Mallin, Lj" uniqKey="Mallin L">LJ Mallin</name></author><author><name sortKey="Tyrrell, C" uniqKey="Tyrrell C">C Tyrrell</name></author><author><name sortKey="Grimes, Gr" uniqKey="Grimes G">GR Grimes</name></author><author><name sortKey="Semple, Ca" uniqKey="Semple C">CA Semple</name></author><author><name sortKey="Nix, Ma" uniqKey="Nix M">MA Nix</name></author><author><name sortKey="Millhauser, Gl" uniqKey="Millhauser G">GL 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