Evaluation of the role of human β-defensin 3 in modulation of immunity and inflammatory response after knee replacement
Identifieur interne : 003E41 ( Pmc/Curation ); précédent : 003E40; suivant : 003E42Evaluation of the role of human β-defensin 3 in modulation of immunity and inflammatory response after knee replacement
Auteurs : Jiguang Jia [République populaire de Chine] ; Hao Peng [République populaire de Chine] ; Sen Chen [République populaire de Chine]Source :
- Experimental and Therapeutic Medicine [ 1792-0981 ] ; 2017.
Abstract
The present study investigated the value of human β-defensin 3 (HBD-3) in adjusting the immunity and inflammatory response of T lymphocytes in the body after knee replacement. Sixty-four cases of knee replacement patients were successively selected and randomly divided into the control group and the observation group each with 32 cases. Once a day, for 7 days, patients in the control group were injected with placebo saline solution in the articular cavity. Levels of Th1 and/Th2, interleukin (IL)-2 and IL-10, tumor necrosis factor (TNF)-α, toll-like receptor (TLR)-4, and alkaline phosphatase (ALP) were compared one month later, and implant infection rates were compared within 1-year follow-up. Compared with patients in the control group, the levels of Th1 and Th1/Th2 in the observation group significantly increased, yet their Th2 decreased. The levels of IL-2 and TNF-α were also observed to be significantly elevated, yet IL-10 decreased. Furthermore, their TLR-4 and ALP levels were significantly higher. Three cases of implant-related infection occurred in the control group and 1 case in the observation group. In conclusion, HBD-3 could adjust the immunity and inflammatory response of cells in the body after knee replacement, possibly playing an important role in implant-related infection.
Url:
DOI: 10.3892/etm.2017.4100
PubMed: 28413475
PubMed Central: 5377263
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<front><div type="abstract" xml:lang="en"><p>The present study investigated the value of human β-defensin 3 (HBD-3) in adjusting the immunity and inflammatory response of T lymphocytes in the body after knee replacement. Sixty-four cases of knee replacement patients were successively selected and randomly divided into the control group and the observation group each with 32 cases. Once a day, for 7 days, patients in the control group were injected with placebo saline solution in the articular cavity. Levels of Th1 and/Th2, interleukin (IL)-2 and IL-10, tumor necrosis factor (TNF)-α, toll-like receptor (TLR)-4, and alkaline phosphatase (ALP) were compared one month later, and implant infection rates were compared within 1-year follow-up. Compared with patients in the control group, the levels of Th1 and Th1/Th2 in the observation group significantly increased, yet their Th2 decreased. The levels of IL-2 and TNF-α were also observed to be significantly elevated, yet IL-10 decreased. Furthermore, their TLR-4 and ALP levels were significantly higher. Three cases of implant-related infection occurred in the control group and 1 case in the observation group. In conclusion, HBD-3 could adjust the immunity and inflammatory response of cells in the body after knee replacement, possibly playing an important role in implant-related infection.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Exp Ther Med</journal-id>
<journal-id journal-id-type="iso-abbrev">Exp Ther Med</journal-id>
<journal-id journal-id-type="publisher-id">ETM</journal-id>
<journal-title-group><journal-title>Experimental and Therapeutic Medicine</journal-title>
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<issn pub-type="ppub">1792-0981</issn>
<issn pub-type="epub">1792-1015</issn>
<publisher><publisher-name>D.A. Spandidos</publisher-name>
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<article-id pub-id-type="pmc">5377263</article-id>
<article-id pub-id-type="doi">10.3892/etm.2017.4100</article-id>
<article-id pub-id-type="publisher-id">ETM-0-0-4100</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles</subject>
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</article-categories>
<title-group><article-title>Evaluation of the role of human β-defensin 3 in modulation of immunity and inflammatory response after knee replacement</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Jia</surname>
<given-names>Jiguang</given-names>
</name>
<xref ref-type="aff" rid="af1-etm-0-0-4100"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peng</surname>
<given-names>Hao</given-names>
</name>
<xref ref-type="aff" rid="af1-etm-0-0-4100"></xref>
<xref rid="c1-etm-0-0-4100" ref-type="corresp"></xref>
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<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Sen</given-names>
</name>
<xref ref-type="aff" rid="af1-etm-0-0-4100"></xref>
</contrib>
</contrib-group>
<aff id="af1-etm-0-0-4100">Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China</aff>
<author-notes><corresp id="c1-etm-0-0-4100"><italic>Correspondence to</italic>
: Dr Hao Peng, Department of Orthopedics, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, Hubei 430060, P.R. China, E-mail: <email>penghao5868@163.com</email>
</corresp>
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<pub-date pub-type="ppub"><month>4</month>
<year>2017</year>
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<pub-date pub-type="epub"><day>06</day>
<month>2</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>06</day>
<month>2</month>
<year>2017</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the . </pmc-comment>
<volume>13</volume>
<issue>4</issue>
<fpage>1343</fpage>
<lpage>1346</lpage>
<history><date date-type="received"><day>26</day>
<month>5</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>23</day>
<month>1</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>Copyright: © Jia et al.</copyright-statement>
<copyright-year>2017</copyright-year>
<license license-type="open-access"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by-nc-nd/4.0/">Creative Commons Attribution-NonCommercial-NoDerivs License</ext-link>
, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.</license-p>
</license>
</permissions>
<abstract><p>The present study investigated the value of human β-defensin 3 (HBD-3) in adjusting the immunity and inflammatory response of T lymphocytes in the body after knee replacement. Sixty-four cases of knee replacement patients were successively selected and randomly divided into the control group and the observation group each with 32 cases. Once a day, for 7 days, patients in the control group were injected with placebo saline solution in the articular cavity. Levels of Th1 and/Th2, interleukin (IL)-2 and IL-10, tumor necrosis factor (TNF)-α, toll-like receptor (TLR)-4, and alkaline phosphatase (ALP) were compared one month later, and implant infection rates were compared within 1-year follow-up. Compared with patients in the control group, the levels of Th1 and Th1/Th2 in the observation group significantly increased, yet their Th2 decreased. The levels of IL-2 and TNF-α were also observed to be significantly elevated, yet IL-10 decreased. Furthermore, their TLR-4 and ALP levels were significantly higher. Three cases of implant-related infection occurred in the control group and 1 case in the observation group. In conclusion, HBD-3 could adjust the immunity and inflammatory response of cells in the body after knee replacement, possibly playing an important role in implant-related infection.</p>
</abstract>
<kwd-group><kwd>human β-defensin 3</kwd>
<kwd>knee replacement</kwd>
<kwd>T lymphocyte</kwd>
<kwd>interleukin-2</kwd>
<kwd>tumor necrosis factor-α</kwd>
<kwd>toll-like receptor 4</kwd>
<kwd>alkaline phosphatase</kwd>
<kwd>implant-related infection</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="f1-etm-0-0-4100" orientation="portrait" position="float"><label>Figure 1.</label>
<caption><p>Th1/Th2 detection by flow cytometry. (A) Th1 count for control group. (B) Th1 count for observation group. (C) Th2 count for control group. (D) Th2 count for observation group.</p>
</caption>
<graphic xlink:href="etm-13-04-1343-g00"></graphic>
</fig>
<table-wrap id="tI-etm-0-0-4100" orientation="portrait" position="float"><label>Table I.</label>
<caption><p>Comparison of Th1/Th2 levels (%).</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" valign="bottom" rowspan="1" colspan="1">Groups</th>
<th align="center" valign="bottom" rowspan="1" colspan="1">Th1</th>
<th align="center" valign="bottom" rowspan="1" colspan="1">Th2</th>
<th align="center" valign="bottom" rowspan="1" colspan="1">Th1/Th2</th>
</tr>
</thead>
<tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Control</td>
<td align="center" valign="top" rowspan="1" colspan="1">13.6±5.2</td>
<td align="center" valign="top" rowspan="1" colspan="1">24.6±5.3</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.6±0.2</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Observation</td>
<td align="center" valign="top" rowspan="1" colspan="1">32.5±6.7</td>
<td align="center" valign="top" rowspan="1" colspan="1">8.7±2.0</td>
<td align="center" valign="top" rowspan="1" colspan="1">5.3±1.4</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">t-test</td>
<td align="center" valign="top" rowspan="1" colspan="1">8.527</td>
<td align="center" valign="top" rowspan="1" colspan="1">9.413</td>
<td align="center" valign="top" rowspan="1" colspan="1">12.534</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">P-value</td>
<td align="center" valign="top" rowspan="1" colspan="1"><0.001</td>
<td align="center" valign="top" rowspan="1" colspan="1"><0.001</td>
<td align="center" valign="top" rowspan="1" colspan="1"><0.001</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="tII-etm-0-0-4100" orientation="portrait" position="float"><label>Table II.</label>
<caption><p>Comparison of IL-2, IL-10 and TNF-α levels (pg/ml).</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" valign="bottom" rowspan="1" colspan="1">Groups</th>
<th align="center" valign="bottom" rowspan="1" colspan="1">IL-2</th>
<th align="center" valign="bottom" rowspan="1" colspan="1">IL-10</th>
<th align="center" valign="bottom" rowspan="1" colspan="1">TNF-α</th>
</tr>
</thead>
<tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Control</td>
<td align="center" valign="top" rowspan="1" colspan="1">140.7±43.6</td>
<td align="center" valign="top" rowspan="1" colspan="1">75.2±23.8</td>
<td align="center" valign="top" rowspan="1" colspan="1">114.7±32.6</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Observation</td>
<td align="center" valign="top" rowspan="1" colspan="1">213.5±52.1</td>
<td align="center" valign="top" rowspan="1" colspan="1">46.9±21.4</td>
<td align="center" valign="top" rowspan="1" colspan="1">156.3±35.5</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">t-test</td>
<td align="center" valign="top" rowspan="1" colspan="1">7.628</td>
<td align="center" valign="top" rowspan="1" colspan="1">7.420</td>
<td align="center" valign="top" rowspan="1" colspan="1">7.306</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">P-value</td>
<td align="center" valign="top" rowspan="1" colspan="1"><0.001</td>
<td align="center" valign="top" rowspan="1" colspan="1"><0.001</td>
<td align="center" valign="top" rowspan="1" colspan="1"><0.001</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="tfn1-etm-0-0-4100"><p>IL, interleukin; TNF-α, tumor necrosis factor-α.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="tIII-etm-0-0-4100" orientation="portrait" position="float"><label>Table III.</label>
<caption><p>Comparison of TLR-4 and ALP levels.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" valign="bottom" rowspan="1" colspan="1">Groups</th>
<th align="center" valign="bottom" rowspan="1" colspan="1">TLR-4 (ng/ml)</th>
<th align="center" valign="bottom" rowspan="1" colspan="1">ALP (U/l)</th>
</tr>
</thead>
<tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Control</td>
<td align="center" valign="top" rowspan="1" colspan="1">10.2±4.0</td>
<td align="center" valign="top" rowspan="1" colspan="1">123.8±48.9</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Observation</td>
<td align="center" valign="top" rowspan="1" colspan="1">15.6±4.2</td>
<td align="center" valign="top" rowspan="1" colspan="1">165.9±54.6</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">t-test</td>
<td align="center" valign="top" rowspan="1" colspan="1">6.968</td>
<td align="center" valign="top" rowspan="1" colspan="1">7.125</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">P-value</td>
<td align="center" valign="top" rowspan="1" colspan="1"><0.001</td>
<td align="center" valign="top" rowspan="1" colspan="1"><0.001</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="tfn2-etm-0-0-4100"><p>TLR-4, toll-like receptor 4; ALP, alkaline phosphatase.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
</record>
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