JankovicV1, Ncbi, Curation, bibRecord, 000200

Clinical Correlates of Depressive Symptoms in Familial Parkinson's Disease

Identifieur interne : 000200 ( Ncbi/Curation ); précédent : 000199; suivant : 000201

Clinical Correlates of Depressive Symptoms in Familial Parkinson's Disease

Auteurs : Nathan Pankratz [États-Unis] ; Karen Marder [États-Unis] ; Cheryl Halter [États-Unis] ; Alice Rudolph [États-Unis] ; Cliff Shults [États-Unis] ; William Nichols [États-Unis] ; Tatiana Foroud [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2008.

RBID : PMC:2872794

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Apolipoproteins E (genetics), DNA Mutational Analysis (methods), Depression (complications), Depression (genetics), Family Health, Female, Humans, Logistic Models, Male, Middle Aged, Mutation (genetics), Parkinson Disease (complications), Parkinson Disease (genetics), Protein-Serine-Threonine Kinases (genetics), RNA-Binding Proteins (genetics), Severity of Illness Index.
MESH :
- chemical , genetics : Apolipoproteins E, Protein-Serine-Threonine Kinases, RNA-Binding Proteins.
- complications : Depression, Parkinson Disease.
- genetics : Depression, Mutation, Parkinson Disease.
- methods : DNA Mutational Analysis.
- Adult, Aged, Aged, 80 and over, Family Health, Female, Humans, Logistic Models, Male, Middle Aged, Severity of Illness Index.

Abstract

Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini-Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS ≥ 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (parkin, LRRK2, APOE). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R² = 0.33; P = 4 × 10⁻⁴⁸). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872794

DOI: 10.1002/mds.22285
PubMed: 18785635
PubMed Central: 2872794

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PMC:2872794

Le document en format XML

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<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA</nlm:aff>
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<author><name sortKey="Nichols, William C" sort="Nichols, William C" uniqKey="Nichols W" first="William" last="Nichols">William Nichols</name>
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<author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana</wicri:regionArea>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Apolipoproteins E (genetics)</term>
<term>DNA Mutational Analysis (methods)</term>
<term>Depression (complications)</term>
<term>Depression (genetics)</term>
<term>Family Health</term>
<term>Female</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation (genetics)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (genetics)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>RNA-Binding Proteins (genetics)</term>
<term>Severity of Illness Index</term>
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<term>Protein-Serine-Threonine Kinases</term>
<term>RNA-Binding Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Depression</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Depression</term>
<term>Mutation</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>DNA Mutational Analysis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Family Health</term>
<term>Female</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini-Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS ≥ 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (<italic>parkin, LRRK2, APOE</italic>
). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R<sup>2</sup>
 = 0.33; <italic>P</italic>
 = 4 × 10<sup>−48</sup>
). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms.</p>
</div>
</front>
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Clinical Correlates of Depressive Symptoms in Familial Parkinson's Disease

Clinical Correlates of Depressive Symptoms in Familial Parkinson's Disease

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Abstract

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