Clinical correlates of depressive symptoms in familial Parkinson's disease.
Identifieur interne : 000133 ( PubMed/Corpus ); précédent : 000132; suivant : 000134Clinical correlates of depressive symptoms in familial Parkinson's disease.
Auteurs : Nathan Pankratz ; Karen. Marder ; Cheryl. Halter ; Alice Rudolph ; Cliff. Shults ; William. Nichols ; Tatiana ForoudSource :
- Movement disorders : official journal of the Movement Disorder Society ; 2008.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Apolipoproteins E (genetics), DNA Mutational Analysis (methods), Depression (complications), Depression (genetics), Family Health, Female, Humans, Logistic Models, Male, Middle Aged, Mutation (genetics), Parkinson Disease (complications), Parkinson Disease (genetics), Protein-Serine-Threonine Kinases (genetics), RNA-Binding Proteins (genetics), Severity of Illness Index.
- MESH :
- chemical , genetics : Apolipoproteins E, Protein-Serine-Threonine Kinases, RNA-Binding Proteins.
- complications : Depression, Parkinson Disease.
- genetics : Depression, Mutation, Parkinson Disease.
- methods : DNA Mutational Analysis.
- Adult, Aged, Aged, 80 and over, Family Health, Female, Humans, Logistic Models, Male, Middle Aged, Severity of Illness Index.
Abstract
Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini-Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS >or= 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (parkin, LRRK2, APOE). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R(2) = 0.33; P = 4 x 10(-48)). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms.
DOI: 10.1002/mds.22285
PubMed: 18785635
Links to Exploration step
pubmed:18785635Le document en format XML
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Halter</name></author><author><name sortKey="Rudolph, Alice" sort="Rudolph, Alice" uniqKey="Rudolph A" first="Alice" last="Rudolph">Alice Rudolph</name></author><author><name sortKey="Shults, Cliff W" sort="Shults, Cliff W" uniqKey="Shults C" first="Cliff" last="Shults">Cliff. Shults</name></author><author><name sortKey="Nichols, William C" sort="Nichols, William C" uniqKey="Nichols W" first="William" last="Nichols">William. Nichols</name></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.22285</idno><idno type="RBID">pubmed:18785635</idno><idno type="pmid">18785635</idno><idno type="wicri:Area/PubMed/Corpus">000133</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical correlates of depressive symptoms in familial Parkinson's disease.</title><author><name sortKey="Pankratz, Nathan" sort="Pankratz, Nathan" uniqKey="Pankratz N" first="Nathan" last="Pankratz">Nathan Pankratz</name><affiliation><nlm:affiliation>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana 46202, USA. npankrat@iupui.edu</nlm:affiliation></affiliation></author><author><name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen" last="Marder">Karen. Marder</name></author><author><name sortKey="Halter, Cheryl A" sort="Halter, Cheryl A" uniqKey="Halter C" first="Cheryl" last="Halter">Cheryl. Halter</name></author><author><name sortKey="Rudolph, Alice" sort="Rudolph, Alice" uniqKey="Rudolph A" first="Alice" last="Rudolph">Alice Rudolph</name></author><author><name sortKey="Shults, Cliff W" sort="Shults, Cliff W" uniqKey="Shults C" first="Cliff" last="Shults">Cliff. Shults</name></author><author><name sortKey="Nichols, William C" sort="Nichols, William C" uniqKey="Nichols W" first="William" last="Nichols">William. Nichols</name></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="e-ISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Apolipoproteins E (genetics)</term><term>DNA Mutational Analysis (methods)</term><term>Depression (complications)</term><term>Depression (genetics)</term><term>Family Health</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Mutation (genetics)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (genetics)</term><term>Protein-Serine-Threonine Kinases (genetics)</term><term>RNA-Binding Proteins (genetics)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoproteins E</term><term>Protein-Serine-Threonine Kinases</term><term>RNA-Binding Proteins</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Depression</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Depression</term><term>Mutation</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>DNA Mutational Analysis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Family Health</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini-Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS >or= 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (parkin, LRRK2, APOE). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R(2) = 0.33; P = 4 x 10(-48)). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18785635</PMID><DateCreated><Year>2008</Year><Month>12</Month><Day>01</Day></DateCreated><DateCompleted><Year>2009</Year><Month>04</Month><Day>08</Day></DateCompleted><DateRevised><Year>2014</Year><Month>09</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>15</Issue><PubDate><Year>2008</Year><Month>Nov</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Clinical correlates of depressive symptoms in familial Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>2216-23</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22285</ELocationID><Abstract><AbstractText>Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini-Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS >or= 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (parkin, LRRK2, APOE). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R(2) = 0.33; P = 4 x 10(-48)). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pankratz</LastName><ForeName>Nathan</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana 46202, USA. npankrat@iupui.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marder</LastName><ForeName>Karen S</ForeName><Initials>KS</Initials></Author><Author ValidYN="Y"><LastName>Halter</LastName><ForeName>Cheryl A</ForeName><Initials>CA</Initials></Author><Author ValidYN="Y"><LastName>Rudolph</LastName><ForeName>Alice</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Shults</LastName><ForeName>Cliff W</ForeName><Initials>CW</Initials></Author><Author ValidYN="Y"><LastName>Nichols</LastName><ForeName>William C</ForeName><Initials>WC</Initials></Author><Author ValidYN="Y"><LastName>Foroud</LastName><ForeName>Tatiana</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><CollectiveName>Parkinson's Study Group-PROGENI Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 NS037167</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS037167-10</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS37167</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., 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RefType="Cites"><RefSource>J Neural Transm (Vienna). 2000;107(1):59-71</RefSource><PMID Version="1">10809404</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2007 Oct 30;69(18):1737-44</RefSource><PMID Version="1">17804834</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2001 Oct;58(10):1611-5</RefSource><PMID Version="1">11594919</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neuropsychiatry Clin Neurosci. 2002 Spring;14(2):223-36; discussion 222</RefSource><PMID Version="1">11983801</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2002 Jul;71(1):124-35</RefSource><PMID Version="1">12058349</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Med Genet. 2002 Jul;39(7):489-92</RefSource><PMID Version="1">12114481</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2003 Mar 11;60(5):796-801</RefSource><PMID Version="1">12629236</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2003 Oct;10(1):23-8</RefSource><PMID Version="1">14499203</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Geriatr Psychiatry Neurol. 2004 Sep;17(3):120-6</RefSource><PMID Version="1">15312275</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Psychiatry. 1968 Jul;114(512):797-811</RefSource><PMID Version="1">5662937</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Psychiatr Res. 1975 Nov;12(3):189-98</RefSource><PMID Version="1">1202204</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Psychiatr Res. 1982-1983;17(1):37-49</RefSource><PMID Version="1">7183759</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol. 1987 Feb;234(2):94-6</RefSource><PMID Version="1">2435855</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):855-8</RefSource><PMID Version="1">3404193</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 1989 Oct;112 ( Pt 5):1141-53</RefSource><PMID Version="1">2804609</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 1990 Oct;40(10):1529-34</RefSource><PMID Version="1">2215943</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Geriatr Soc. 1991 Sep;39(9):876-80</RefSource><PMID Version="1">1885862</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 1992 Mar;49(3):305-7</RefSource><PMID Version="1">1536634</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 1992 May;55(5):377-82</RefSource><PMID Version="1">1602311</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 1995 Jul;52(7):695-701</RefSource><PMID Version="1">7619026</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 1996 Feb;53(2):175-9</RefSource><PMID Version="1">8639068</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 1996 Jul;47(1):256-9</RefSource><PMID Version="1">8710089</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neural Transm (Vienna). 1996;103(3):349-54</RefSource><PMID Version="1">8739846</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neuropsychiatry Clin Neurosci. 1996 Winter;8(1):20-5</RefSource><PMID Version="1">8845697</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 1997 Jan;62(1):10-5</RefSource><PMID Version="1">9010393</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 1997 May;54(5):625-30</RefSource><PMID Version="1">9152120</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol. 1997 Aug;244(8):493-8</RefSource><PMID Version="1">9309555</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 1999 Mar;56(3):334-7</RefSource><PMID Version="1">10190824</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2005 Jan 29-Feb 4;365(9457):410-2</RefSource><PMID Version="1">15680455</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2005 Jun 28;64(12):2134-5</RefSource><PMID Version="1">15985588</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 2005 Oct;76(10):1445-7</RefSource><PMID Version="1">16170093</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2006 Jan;21(1):45-9</RefSource><PMID Version="1">16116614</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2006 Mar 28;66(6):956; author reply 956</RefSource><PMID Version="1">16567734</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Neurol. 2006;17(2):109-15</RefSource><PMID Version="1">16873922</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2006 Oct;21(10):1618-22</RefSource><PMID Version="1">16817205</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Sci. 2006 Oct 25;248(1-2):138-42</RefSource><PMID Version="1">16814323</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2006 Dec;21(12):2257-60</RefSource><PMID Version="1">17078063</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 2007 Feb;78(2):123-6</RefSource><PMID Version="1">16980336</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Neuropharmacol. 2000 Nov-Dec;23(6):331-4</RefSource><PMID Version="1">11575867</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001057">Apolipoproteins E</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004252">DNA Mutational Analysis</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" 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