Depressed mood and memory impairment before and after unilateral posteroventral pallidotomy in Parkinson's disease.
Identifieur interne : 000201 ( Ncbi/Curation ); précédent : 000200; suivant : 000202Depressed mood and memory impairment before and after unilateral posteroventral pallidotomy in Parkinson's disease.
Auteurs : Mario. Dulay [États-Unis] ; Adriana. Strutt ; Harvey. Levin ; Joseph Jankovic [États-Unis] ; Eugene. Lai ; Robert. Grossman ; Michele. YorkSource :
- The Journal of neuropsychiatry and clinical neurosciences ; 2008.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Depressive Disorder (etiology), Female, Functional Laterality, Humans, Male, Memory Disorders (etiology), Middle Aged, Neurologic Examination, Neuropsychological Tests, Pallidotomy (adverse effects), Pallidotomy (methods), Parkinson Disease (surgery), Severity of Illness Index.
- MESH :
- adverse effects : Pallidotomy.
- etiology : Depressive Disorder, Memory Disorders.
- methods : Pallidotomy.
- surgery : Parkinson Disease.
- Aged, Analysis of Variance, Female, Functional Laterality, Humans, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Severity of Illness Index.
Abstract
This study evaluated poor mood state as a moderator of changes in verbal recall ability from before to after unilateral posteroventral pallidotomy in 54 individuals with advanced Parkinson's disease. Repeated-measures analysis of covariance (controlling for motor disease severity) indicated that left-posteroventral pallidotomy subjects with depressed mood performed more poorly on measures of verbal list learning and story recall compared to nondepressed subjects or right-posteroventral pallidotomy subjects with depressed mood both before and after surgery. The results suggest that depressed mood should be taken into account when interpreting memory test performance in Parkinson's disease surgical candidates both before and after surgery.
DOI: 10.1176/jnp.2008.20.3.357
PubMed: 18806240
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pubmed:18806240Le document en format XML
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<series><title level="j">The Journal of neuropsychiatry and clinical neurosciences</title>
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<term>Functional Laterality</term>
<term>Humans</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">This study evaluated poor mood state as a moderator of changes in verbal recall ability from before to after unilateral posteroventral pallidotomy in 54 individuals with advanced Parkinson's disease. Repeated-measures analysis of covariance (controlling for motor disease severity) indicated that left-posteroventral pallidotomy subjects with depressed mood performed more poorly on measures of verbal list learning and story recall compared to nondepressed subjects or right-posteroventral pallidotomy subjects with depressed mood both before and after surgery. The results suggest that depressed mood should be taken into account when interpreting memory test performance in Parkinson's disease surgical candidates both before and after surgery.</div>
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