Clinical Assessment of the Effect of Tetrabenazine on Functional Scales in Huntington Disease: A Pilot Open Label Study
Identifieur interne : 000178 ( Main/Exploration ); précédent : 000177; suivant : 000179Clinical Assessment of the Effect of Tetrabenazine on Functional Scales in Huntington Disease: A Pilot Open Label Study
Auteurs : Robert Fekete [États-Unis] ; Anthony Davidson [États-Unis] ; Joseph Jankovic [États-Unis]Source :
- Tremor and Other Hyperkinetic Movements ; 2012.
Abstract
Tetrabenazine is a monoamine depleter with a well-documented effect against chorea associated with Huntington disease (HD). There is a paucity of data about how reduction in chorea relates to better performance on motor, gait, cognitive, and psychiatric assessments.
We designed an open label tetrabenazine withdrawal study to test performance using validated scales. The following instruments were used to assess cognitive, behavioral, and motor function in 10 patients with documented HD: The Montreal Cognitive Assessment, Beck Depression Inventory II, Dynamic Gait Index (DGI), Jebsen Hand Test, Timed 25-foot walk, Berg Balance Test (BBT), QuickDASH, and the Unified Huntington Disease Rating Scale (UHDRS) Motor, Stroop Color Word, Behavioral Assessment, Functional Checklist, and Independence Scale.
Subjects performed significantly better while on tetrabenazine as measured by the DGI (p = 0.041), BBT (p = 0.007), and the UHDRS Total Motor (p = 0.009), Maximum Chorea (p = 0.005), and Stroop Color-Word tests (p = 0.028).
This pilot study demonstrates tetrabenazine's potential effects beyond improvement in chorea.
Url:
PubMed: 23439575
PubMed Central: 3569975
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000121
- to stream Pmc, to step Curation: 000121
- to stream Pmc, to step Checkpoint: 000109
- to stream Ncbi, to step Merge: 000401
- to stream Ncbi, to step Curation: 000401
- to stream Ncbi, to step Checkpoint: 000401
- to stream Main, to step Merge: 000179
- to stream Main, to step Curation: 000178
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical Assessment of the Effect of Tetrabenazine on Functional Scales in Huntington Disease: A Pilot Open Label Study</title><author><name sortKey="Fekete, Robert" sort="Fekete, Robert" uniqKey="Fekete R" first="Robert" last="Fekete">Robert Fekete</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Davidson, Anthony" sort="Davidson, Anthony" uniqKey="Davidson A" first="Anthony" last="Davidson">Anthony Davidson</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23439575</idno><idno type="pmc">3569975</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569975</idno><idno type="RBID">PMC:3569975</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000121</idno><idno type="wicri:Area/Pmc/Curation">000121</idno><idno type="wicri:Area/Pmc/Checkpoint">000109</idno><idno type="wicri:Area/Ncbi/Merge">000401</idno><idno type="wicri:Area/Ncbi/Curation">000401</idno><idno type="wicri:Area/Ncbi/Checkpoint">000401</idno><idno type="wicri:Area/Main/Merge">000179</idno><idno type="wicri:Area/Main/Curation">000178</idno><idno type="wicri:Area/Main/Exploration">000178</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical Assessment of the Effect of Tetrabenazine on Functional Scales in Huntington Disease: A Pilot Open Label Study</title><author><name sortKey="Fekete, Robert" sort="Fekete, Robert" uniqKey="Fekete R" first="Robert" last="Fekete">Robert Fekete</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Davidson, Anthony" sort="Davidson, Anthony" uniqKey="Davidson A" first="Anthony" last="Davidson">Anthony Davidson</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></analytic><series><title level="j">Tremor and Other Hyperkinetic Movements</title><idno type="e-ISSN">2160-8288</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Tetrabenazine is a monoamine depleter with a well-documented effect against chorea associated with Huntington disease (HD). There is a paucity of data about how reduction in chorea relates to better performance on motor, gait, cognitive, and psychiatric assessments.</p></sec><sec><title>Methods</title><p>We designed an open label tetrabenazine withdrawal study to test performance using validated scales. The following instruments were used to assess cognitive, behavioral, and motor function in 10 patients with documented HD: The Montreal Cognitive Assessment, Beck Depression Inventory II, Dynamic Gait Index (DGI), Jebsen Hand Test, Timed 25-foot walk, Berg Balance Test (BBT), QuickDASH, and the Unified Huntington Disease Rating Scale (UHDRS) Motor, Stroop Color Word, Behavioral Assessment, Functional Checklist, and Independence Scale.</p></sec><sec><title>Results</title><p>Subjects performed significantly better while on tetrabenazine as measured by the DGI (p = 0.041), BBT (p = 0.007), and the UHDRS Total Motor (p = 0.009), Maximum Chorea (p = 0.005), and Stroop Color-Word tests (p = 0.028).</p></sec><sec><title>Discussion</title><p>This pilot study demonstrates tetrabenazine's potential effects beyond improvement in chorea.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jankovic, J" uniqKey="Jankovic J">J Jankovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jankovic, J" uniqKey="Jankovic J">J Jankovic</name></author><author><name sortKey="Clarence Smith, K" uniqKey="Clarence Smith K">K Clarence-Smith</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Koller, Wc" uniqKey="Koller W">WC Koller</name></author><author><name sortKey="Trimble, J" uniqKey="Trimble J">J Trimble</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonelli, Rm" uniqKey="Bonelli R">RM Bonelli</name></author><author><name sortKey="Mahnert, Fa" uniqKey="Mahnert F">FA Mahnert</name></author><author><name sortKey="Niederwieser, G" uniqKey="Niederwieser G">G Niederwieser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferrara, Jm" uniqKey="Ferrara J">JM Ferrara</name></author><author><name sortKey="Mostile, G" uniqKey="Mostile G">G Mostile</name></author><author><name sortKey="Hunter, C" uniqKey="Hunter C">C Hunter</name></author><author><name sortKey="Adam, Or" uniqKey="Adam O">OR Adam</name></author><author><name sortKey="Jankovic, J" uniqKey="Jankovic J">J Jankovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Videnovic, A" uniqKey="Videnovic A">A Videnovic</name></author><author><name sortKey="Bernard, B" uniqKey="Bernard B">B Bernard</name></author><author><name sortKey="Fan, W" uniqKey="Fan W">W Fan</name></author><author><name sortKey="Jaglin, J" uniqKey="Jaglin J">J Jaglin</name></author><author><name sortKey="Leurgans, S" uniqKey="Leurgans S">S Leurgans</name></author><author><name sortKey="Shannon, Km" uniqKey="Shannon K">KM Shannon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steer, Ra" uniqKey="Steer R">RA Steer</name></author><author><name sortKey="Ball, R" uniqKey="Ball R">R Ball</name></author><author><name sortKey="Ranieri, Wf" uniqKey="Ranieri W">WF Ranieri</name></author><author><name sortKey="Beck, At" uniqKey="Beck A">AT Beck</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Berg, Ko" uniqKey="Berg K">KO Berg</name></author><author><name sortKey="Maki, Be" uniqKey="Maki B">BE Maki</name></author><author><name sortKey="Williams, Ji" uniqKey="Williams J">JI Williams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berg, Ko" uniqKey="Berg K">KO Berg</name></author><author><name sortKey="Wood Dauphinee, Sl" uniqKey="Wood Dauphinee S">SL Wood-Dauphinee</name></author><author><name sortKey="Williams, Jt" uniqKey="Williams J">JT Williams</name></author><author><name sortKey="Maki, B" uniqKey="Maki B">B Maki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, Ja" uniqKey="Cohen J">JA Cohen</name></author><author><name sortKey="Cutter, Gr" uniqKey="Cutter G">GR Cutter</name></author><author><name sortKey="Fischer, Js" uniqKey="Fischer J">JS Fischer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jebsen, Rh" uniqKey="Jebsen R">RH Jebsen</name></author><author><name sortKey="Taylor, N" uniqKey="Taylor N">N Taylor</name></author><author><name sortKey="Trieschmann, Rb" uniqKey="Trieschmann R">RB Trieschmann</name></author><author><name sortKey="Trotter, Mj" uniqKey="Trotter M">MJ Trotter</name></author><author><name sortKey="Howard, La" uniqKey="Howard L">LA Howard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beaton, De" uniqKey="Beaton D">DE Beaton</name></author><author><name sortKey="Wright, Jg" uniqKey="Wright J">JG Wright</name></author><author><name sortKey="Katz, Jn" uniqKey="Katz J">JN Katz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whitney, Sl" uniqKey="Whitney S">SL Whitney</name></author><author><name sortKey="Hudak, Mt" uniqKey="Hudak M">MT Hudak</name></author><author><name sortKey="Marchetti, Gf" uniqKey="Marchetti G">GF Marchetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tian, J" uniqKey="Tian J">J Tian</name></author><author><name sortKey="Herdman, Sj" uniqKey="Herdman S">SJ Herdman</name></author><author><name sortKey="Zee, Ds" uniqKey="Zee D">DS Zee</name></author><author><name sortKey="Folstein, Se" uniqKey="Folstein S">SE Folstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salomonczyk, D" uniqKey="Salomonczyk D">D Salomonczyk</name></author><author><name sortKey="Panzera, R" uniqKey="Panzera R">R Panzera</name></author><author><name sortKey="Pirogovosky, E" uniqKey="Pirogovosky E">E Pirogovosky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scholes, Ke" uniqKey="Scholes K">KE Scholes</name></author><author><name sortKey="Harrison, Bj" uniqKey="Harrison B">BJ Harrison</name></author><author><name sortKey="O Neill, Bv" uniqKey="O Neill B">BV O'Neill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez Pernaute, R" uniqKey="Sanchez Pernaute R">R Sánchez-Pernaute</name></author><author><name sortKey="Kunig, G" uniqKey="Kunig G">G Künig</name></author><author><name sortKey="Del Barrio Alba, A" uniqKey="Del Barrio Alba A">A del Barrio Alba</name></author><author><name sortKey="De Yebenes, Jg" uniqKey="De Yebenes J">JG de Yébenes</name></author><author><name sortKey="Vontobel, P" uniqKey="Vontobel P">P Vontobel</name></author><author><name sortKey="Leenders, Kl" uniqKey="Leenders K">KL Leenders</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Ma" uniqKey="Smith M">MA Smith</name></author><author><name sortKey="Brandt, J" uniqKey="Brandt J">J Brandt</name></author><author><name sortKey="Shadmehr, R" uniqKey="Shadmehr R">R Shadmehr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paleacu, D" uniqKey="Paleacu D">D Paleacu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frank, S" uniqKey="Frank S">S Frank</name></author><author><name sortKey="Ondo, W" uniqKey="Ondo W">W Ondo</name></author><author><name sortKey="Fahn, S" uniqKey="Fahn S">S Fahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frank, S" uniqKey="Frank S">S Frank</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Satou, T" uniqKey="Satou T">T Satou</name></author><author><name sortKey="Anderson, Aj" uniqKey="Anderson A">AJ Anderson</name></author><author><name sortKey="Itoh, T" uniqKey="Itoh T">T Itoh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Butler, Pd" uniqKey="Butler P">PD Butler</name></author><author><name sortKey="Edwards, E" uniqKey="Edwards E">E Edwards</name></author><author><name sortKey="Barkai, I" uniqKey="Barkai I">I Barkai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chafetz, Md" uniqKey="Chafetz M">MD Chafetz</name></author><author><name sortKey="Matthews, Lh" uniqKey="Matthews L">LH Matthews</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Fekete, Robert" sort="Fekete, Robert" uniqKey="Fekete R" first="Robert" last="Fekete">Robert Fekete</name></region><name sortKey="Davidson, Anthony" sort="Davidson, Anthony" uniqKey="Davidson A" first="Anthony" last="Davidson">Anthony Davidson</name><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/JankovicV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000178 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000178 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= JankovicV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3569975
|texte= Clinical Assessment of the Effect of Tetrabenazine on Functional Scales in Huntington Disease: A Pilot Open Label Study
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23439575" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a JankovicV1
| This area was generated with Dilib version V0.6.19. |  |