Cognitive Impairment and Dementia in Parkinson’s Disease: Clinical Features, Diagnosis, and Management
Identifieur interne : 000177 ( Main/Exploration ); précédent : 000176; suivant : 000178Cognitive Impairment and Dementia in Parkinson’s Disease: Clinical Features, Diagnosis, and Management
Auteurs : Joana Meireles [Portugal] ; João Massano [Portugal]Source :
- Frontiers in Neurology ; 2012.
Abstract
Parkinson’s disease (PD) is a common, disabling, neurodegenerative disorder. In addition to classical motor symptoms, non-motor features are now widely accepted as part of the clinical picture, and cognitive decline is a very important aspect of the disease, as it brings an additional significant burden for the patient and caregivers. The diagnosis of cognitive decline in PD, namely mild cognitive impairment (MCI) and dementia, can be extremely challenging, remaining largely based on clinical and cognitive assessments. Diagnostic criteria and methods for PD dementia and MCI have been recently issued by expert work groups. This manuscript has synthesized relevant data in order to obtain a pragmatic and updated review regarding cognitive decline in PD, from milder stages to dementia. This text will summarize clinical features, diagnostic methodology, and therapeutic issues of clinical decline in PD. Relevant clinical genetic issues, including recent advances, will also be approached.
Url:
DOI: 10.3389/fneur.2012.00088
PubMed: 22654785
PubMed Central: 3360424
Affiliations:
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xml:lang="fr">Portugal</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Massano, Joao" sort="Massano, Joao" uniqKey="Massano J" first="João" last="Massano">João Massano</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Neurology, Centro Hospitalar de São João</institution><country>Porto, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Clinical Neuroscience and Mental Health, Faculty of Medicine University of Porto</institution><country>Porto, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Movement Disorders and Functional Surgery Unit, Centro Hospitalar de São João</institution><country>Porto, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Neurology</title><idno type="e-ISSN">1664-2295</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Parkinson’s disease (PD) is a common, disabling, neurodegenerative disorder. In addition to classical motor symptoms, non-motor features are now widely accepted as part of the clinical picture, and cognitive decline is a very important aspect of the disease, as it brings an additional significant burden for the patient and caregivers. The diagnosis of cognitive decline in PD, namely mild cognitive impairment (MCI) and dementia, can be extremely challenging, remaining largely based on clinical and cognitive assessments. Diagnostic criteria and methods for PD dementia and MCI have been recently issued by expert work groups. This manuscript has synthesized relevant data in order to obtain a pragmatic and updated review regarding cognitive decline in PD, from milder stages to dementia. This text will summarize clinical features, diagnostic methodology, and therapeutic issues of clinical decline in PD. 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Melamed</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Portugal</li></country></list><tree><country name="Portugal"><noRegion><name sortKey="Meireles, Joana" sort="Meireles, Joana" uniqKey="Meireles J" first="Joana" last="Meireles">Joana Meireles</name></noRegion><name sortKey="Massano, Joao" sort="Massano, Joao" uniqKey="Massano J" first="João" last="Massano">João Massano</name><name sortKey="Massano, Joao" sort="Massano, Joao" uniqKey="Massano J" first="João" last="Massano">João Massano</name><name sortKey="Massano, Joao" sort="Massano, Joao" uniqKey="Massano J" first="João" last="Massano">João Massano</name><name sortKey="Meireles, Joana" sort="Meireles, Joana" uniqKey="Meireles J" first="Joana" last="Meireles">Joana Meireles</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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