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Serveur d'exploration autour de Joseph Jankovic

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Clinical Assessment of the Effect of Tetrabenazine on Functional Scales in Huntington Disease: A Pilot Open Label Study

Identifieur interne : 000121 ( Pmc/Corpus ); précédent : 000120; suivant : 000122

Clinical Assessment of the Effect of Tetrabenazine on Functional Scales in Huntington Disease: A Pilot Open Label Study

Auteurs : Robert Fekete ; Anthony Davidson ; Joseph Jankovic

Source :

RBID : PMC:3569975

Abstract

Background

Tetrabenazine is a monoamine depleter with a well-documented effect against chorea associated with Huntington disease (HD). There is a paucity of data about how reduction in chorea relates to better performance on motor, gait, cognitive, and psychiatric assessments.

Methods

We designed an open label tetrabenazine withdrawal study to test performance using validated scales. The following instruments were used to assess cognitive, behavioral, and motor function in 10 patients with documented HD: The Montreal Cognitive Assessment, Beck Depression Inventory II, Dynamic Gait Index (DGI), Jebsen Hand Test, Timed 25-foot walk, Berg Balance Test (BBT), QuickDASH, and the Unified Huntington Disease Rating Scale (UHDRS) Motor, Stroop Color Word, Behavioral Assessment, Functional Checklist, and Independence Scale.

Results

Subjects performed significantly better while on tetrabenazine as measured by the DGI (p = 0.041), BBT (p = 0.007), and the UHDRS Total Motor (p = 0.009), Maximum Chorea (p = 0.005), and Stroop Color-Word tests (p = 0.028).

Discussion

This pilot study demonstrates tetrabenazine's potential effects beyond improvement in chorea.


Url:
PubMed: 23439575
PubMed Central: 3569975

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Data generation: Wed Feb 10 22:03:07 2016. Site generation: Tue Feb 13 16:14:27 2024