Analysis of the influenza virus gene pool of avian species from southern China.
Identifieur interne : 000418 ( PubMed/Corpus ); précédent : 000417; suivant : 000419Analysis of the influenza virus gene pool of avian species from southern China.
Auteurs : Y P Lin ; L L Shu ; S. Wright ; W J Bean ; G B Sharp ; K F Shortridge ; R G WebsterSource :
- Virology [ 0042-6822 ] ; 1994.
English descriptors
- KwdEn :
- Animals, Base Sequence, China (epidemiology), Cloning, Molecular, Disease Reservoirs, Genes, Viral, Influenza A virus (classification), Influenza A virus (genetics), Influenza A virus (isolation & purification), Influenza in Birds (epidemiology), Molecular Sequence Data, Nucleic Acid Hybridization, Phylogeny, Poultry (microbiology), RNA, Viral (genetics), Recombination, Genetic, Sequence Analysis, DNA.
- MESH :
- chemical , genetics : RNA, Viral.
- geographic , epidemiology : China.
- classification : Influenza A virus.
- epidemiology : Influenza in Birds.
- genetics : Influenza A virus.
- isolation & purification : Influenza A virus.
- microbiology : Poultry.
- Animals, Base Sequence, Cloning, Molecular, Disease Reservoirs, Genes, Viral, Molecular Sequence Data, Nucleic Acid Hybridization, Phylogeny, Recombination, Genetic, Sequence Analysis, DNA.
Abstract
Although Southern China has been considered the epicenter of human influenza pandemics, little is known about the genetic composition of influenza viruses in lower mammals or birds in that region. To provide information on the molecular epidemiology of these viruses, we used dot blot hybridization and phylogenetic methods to study the internal genes (PB1, PB2, PA, NP, M, and NS) of 106 avian influenza A viruses isolated from a total of 11,798 domestic ducks, chickens, and geese raised in Southern China including Hong Kong. All 636 genes examined were characteristic of avian influenza viruses; no human or swine influenza genes were detected. Thus, influenza virus reassortants do not appear to be maintained in the domesticated birds of Southeast Asia, eliminating opportunities for further gene reassortment. Phylogenetic analysis showed that the internal genes of these viruses belong to the Eurasian avian lineage, supporting geographical separation of the major avian lineages. The PB1 genes were most similar to A/Singapore/57 (H2N2) and Hong Kong (H3N2) viral genes, supporting an avian origin for the recent human H2N2 and H3N2 pandemic strains. The majority of internal genes from avian influenza viruses in Southern China belong to the Eurasian lineage and are similar to viruses that have recently been transmitted to humans, swine, and horses. This study provides evidence that the transmission of avian influenza viruses and their genes to other species is unidirectional and that the transmission of mammalian influenza virus strains to domestic poultry is probably not a factor in the generation of new pandemic strains.
DOI: 10.1006/viro.1994.1067
PubMed: 8291238
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pubmed:8291238Le document en format XML
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Wright</name></author><author><name sortKey="Bean, W J" sort="Bean, W J" uniqKey="Bean W" first="W J" last="Bean">W J Bean</name></author><author><name sortKey="Sharp, G B" sort="Sharp, G B" uniqKey="Sharp G" first="G B" last="Sharp">G B Sharp</name></author><author><name sortKey="Shortridge, K F" sort="Shortridge, K F" uniqKey="Shortridge K" first="K F" last="Shortridge">K F Shortridge</name></author><author><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R G" last="Webster">R G Webster</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1994">1994</date><idno type="RBID">pubmed:8291238</idno><idno type="pmid">8291238</idno><idno type="doi">10.1006/viro.1994.1067</idno><idno type="wicri:Area/PubMed/Corpus">000418</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000418</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Analysis of the influenza virus gene pool of avian species from southern China.</title><author><name sortKey="Lin, Y P" sort="Lin, Y P" uniqKey="Lin Y" first="Y P" last="Lin">Y P Lin</name><affiliation><nlm:affiliation>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.</nlm:affiliation></affiliation></author><author><name sortKey="Shu, L L" sort="Shu, L L" uniqKey="Shu L" first="L L" last="Shu">L L Shu</name></author><author><name sortKey="Wright, S" sort="Wright, S" uniqKey="Wright S" first="S" last="Wright">S. Wright</name></author><author><name sortKey="Bean, W J" sort="Bean, W J" uniqKey="Bean W" first="W J" last="Bean">W J Bean</name></author><author><name sortKey="Sharp, G B" sort="Sharp, G B" uniqKey="Sharp G" first="G B" last="Sharp">G B Sharp</name></author><author><name sortKey="Shortridge, K F" sort="Shortridge, K F" uniqKey="Shortridge K" first="K F" last="Shortridge">K F Shortridge</name></author><author><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R G" last="Webster">R G Webster</name></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>China (epidemiology)</term><term>Cloning, Molecular</term><term>Disease Reservoirs</term><term>Genes, Viral</term><term>Influenza A virus (classification)</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (isolation & purification)</term><term>Influenza in Birds (epidemiology)</term><term>Molecular Sequence Data</term><term>Nucleic Acid Hybridization</term><term>Phylogeny</term><term>Poultry (microbiology)</term><term>RNA, Viral (genetics)</term><term>Recombination, Genetic</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Poultry</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Cloning, Molecular</term><term>Disease Reservoirs</term><term>Genes, Viral</term><term>Molecular Sequence Data</term><term>Nucleic Acid Hybridization</term><term>Phylogeny</term><term>Recombination, Genetic</term><term>Sequence Analysis, DNA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although Southern China has been considered the epicenter of human influenza pandemics, little is known about the genetic composition of influenza viruses in lower mammals or birds in that region. To provide information on the molecular epidemiology of these viruses, we used dot blot hybridization and phylogenetic methods to study the internal genes (PB1, PB2, PA, NP, M, and NS) of 106 avian influenza A viruses isolated from a total of 11,798 domestic ducks, chickens, and geese raised in Southern China including Hong Kong. All 636 genes examined were characteristic of avian influenza viruses; no human or swine influenza genes were detected. Thus, influenza virus reassortants do not appear to be maintained in the domesticated birds of Southeast Asia, eliminating opportunities for further gene reassortment. Phylogenetic analysis showed that the internal genes of these viruses belong to the Eurasian avian lineage, supporting geographical separation of the major avian lineages. The PB1 genes were most similar to A/Singapore/57 (H2N2) and Hong Kong (H3N2) viral genes, supporting an avian origin for the recent human H2N2 and H3N2 pandemic strains. The majority of internal genes from avian influenza viruses in Southern China belong to the Eurasian lineage and are similar to viruses that have recently been transmitted to humans, swine, and horses. This study provides evidence that the transmission of avian influenza viruses and their genes to other species is unidirectional and that the transmission of mammalian influenza virus strains to domestic poultry is probably not a factor in the generation of new pandemic strains.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8291238</PMID><DateCompleted><Year>1994</Year><Month>02</Month><Day>24</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0042-6822</ISSN><JournalIssue CitedMedium="Print"><Volume>198</Volume><Issue>2</Issue><PubDate><Year>1994</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Virology</Title><ISOAbbreviation>Virology</ISOAbbreviation></Journal><ArticleTitle>Analysis of the influenza virus gene pool of avian species from southern China.</ArticleTitle><Pagination><MedlinePgn>557-66</MedlinePgn></Pagination><Abstract><AbstractText>Although Southern China has been considered the epicenter of human influenza pandemics, little is known about the genetic composition of influenza viruses in lower mammals or birds in that region. To provide information on the molecular epidemiology of these viruses, we used dot blot hybridization and phylogenetic methods to study the internal genes (PB1, PB2, PA, NP, M, and NS) of 106 avian influenza A viruses isolated from a total of 11,798 domestic ducks, chickens, and geese raised in Southern China including Hong Kong. All 636 genes examined were characteristic of avian influenza viruses; no human or swine influenza genes were detected. Thus, influenza virus reassortants do not appear to be maintained in the domesticated birds of Southeast Asia, eliminating opportunities for further gene reassortment. Phylogenetic analysis showed that the internal genes of these viruses belong to the Eurasian avian lineage, supporting geographical separation of the major avian lineages. The PB1 genes were most similar to A/Singapore/57 (H2N2) and Hong Kong (H3N2) viral genes, supporting an avian origin for the recent human H2N2 and H3N2 pandemic strains. The majority of internal genes from avian influenza viruses in Southern China belong to the Eurasian lineage and are similar to viruses that have recently been transmitted to humans, swine, and horses. 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Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009693" MajorTopicYN="N">Nucleic Acid Hybridization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011200" MajorTopicYN="N">Poultry</DescriptorName><QualifierName UI="Q000382" 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