Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4+ T-cell help in CD8+ T-cell responses.
Identifieur interne : 000417 ( PubMed/Corpus ); précédent : 000416; suivant : 000418Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4+ T-cell help in CD8+ T-cell responses.
Auteurs : Y. Wu ; Y. LiuSource :
- Current biology : CB [ 0960-9822 ] ; 1994.
English descriptors
- KwdEn :
- Animals, Antigen-Presenting Cells (immunology), CD4-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (immunology), In Vitro Techniques, Influenza A virus (classification), Influenza A virus (immunology), Lymphocyte Activation, Lymphocyte Cooperation, Mice, Mice, Inbred BALB C, Mice, Inbred CBA, Models, Biological.
- MESH :
Abstract
CD4+ T-cell help is critical for cytotoxic (CD8+) T-lymphocyte responses to many antigens, such as viruses, minor histocompatibility antigens and allogeneic major histocompatibility antigens. However, the nature of such help is still a mystery: cytokines such as interleukin-2 may be involved but cell-cell contact may also be necessary. As some viruses can induce CD8+ T-cell responses in the absence of CD4+ T cells, we asked whether these viruses and CD4+ cells share a pathway for helping the CD8+ T-cell response.
DOI: 10.1016/s0960-9822(00)00110-x
PubMed: 7922370
Links to Exploration step
pubmed:7922370Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4+ T-cell help in CD8+ T-cell responses.</title><author><name sortKey="Wu, Y" sort="Wu, Y" uniqKey="Wu Y" first="Y" last="Wu">Y. Wu</name><affiliation><nlm:affiliation>Department of Pathology, New York University Medical Center, New York 10016.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Y" sort="Liu, Y" uniqKey="Liu Y" first="Y" last="Liu">Y. Liu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1994">1994</date><idno type="RBID">pubmed:7922370</idno><idno type="pmid">7922370</idno><idno type="doi">10.1016/s0960-9822(00)00110-x</idno><idno type="wicri:Area/PubMed/Corpus">000417</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000417</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4+ T-cell help in CD8+ T-cell responses.</title><author><name sortKey="Wu, Y" sort="Wu, Y" uniqKey="Wu Y" first="Y" last="Wu">Y. Wu</name><affiliation><nlm:affiliation>Department of Pathology, New York University Medical Center, New York 10016.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Y" sort="Liu, Y" uniqKey="Liu Y" first="Y" last="Liu">Y. Liu</name></author></analytic><series><title level="j">Current biology : CB</title><idno type="ISSN">0960-9822</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigen-Presenting Cells (immunology)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>In Vitro Techniques</term><term>Influenza A virus (classification)</term><term>Influenza A virus (immunology)</term><term>Lymphocyte Activation</term><term>Lymphocyte Cooperation</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred CBA</term><term>Models, Biological</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Antigen-Presenting Cells</term><term>CD4-Positive T-Lymphocytes</term><term>CD8-Positive T-Lymphocytes</term><term>Influenza A virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>In Vitro Techniques</term><term>Lymphocyte Activation</term><term>Lymphocyte Cooperation</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred CBA</term><term>Models, Biological</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">CD4+ T-cell help is critical for cytotoxic (CD8+) T-lymphocyte responses to many antigens, such as viruses, minor histocompatibility antigens and allogeneic major histocompatibility antigens. However, the nature of such help is still a mystery: cytokines such as interleukin-2 may be involved but cell-cell contact may also be necessary. As some viruses can induce CD8+ T-cell responses in the absence of CD4+ T cells, we asked whether these viruses and CD4+ cells share a pathway for helping the CD8+ T-cell response.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">7922370</PMID><DateCompleted><Year>1994</Year><Month>11</Month><Day>18</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>28</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0960-9822</ISSN><JournalIssue CitedMedium="Print"><Volume>4</Volume><Issue>6</Issue><PubDate><Year>1994</Year><Month>Jun</Month><Day>01</Day></PubDate></JournalIssue><Title>Current biology : CB</Title><ISOAbbreviation>Curr. Biol.</ISOAbbreviation></Journal><ArticleTitle>Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4+ T-cell help in CD8+ T-cell responses.</ArticleTitle><Pagination><MedlinePgn>499-505</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">CD4+ T-cell help is critical for cytotoxic (CD8+) T-lymphocyte responses to many antigens, such as viruses, minor histocompatibility antigens and allogeneic major histocompatibility antigens. However, the nature of such help is still a mystery: cytokines such as interleukin-2 may be involved but cell-cell contact may also be necessary. As some viruses can induce CD8+ T-cell responses in the absence of CD4+ T cells, we asked whether these viruses and CD4+ cells share a pathway for helping the CD8+ T-cell response.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We show here that the H2N2 subtype of influenza virus, which elicits a CD4+ T-cell-independent anti-viral CD8+ T-cell response in vitro, induces expression of the co-stimulatory molecule B7-2, but not of B7, on the cell surface of antigen-presenting cells. In contrast, the H1N1 subtype of influenza virus, which requires CD4+ T-cell help to elicit CD8+ T-cell responses under the same conditions, does not induce B7-2 expression. We also find that CD4+ T cells can induce expression of B7-2 on antigen-presenting cells. In both cases, the induced B7-2 is necessary for the clonal expansion and functional maturation of CD8+ T cells.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our results support the view that the induction of co-stimulatory activity on antigen-presenting cells by CD4+ T cells can substitute for the requirement for exogenous interleukin-2 in CD8+ T-cell help. Viruses that can induce co-stimulatory activity on antigen-presenting cells thus induce a CD4+ T-cell-independent CD8+ T-cell response. These findings could explain the reported differences in the requirements for CD4+ T cells in CD8+ T-cell responses.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Y</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pathology, New York University Medical Center, New York 10016.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Curr Biol</MedlineTA><NlmUniqueID>9107782</NlmUniqueID><ISSNLinking>0960-9822</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CitationSubset>X</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000938" MajorTopicYN="N">Antigen-Presenting Cells</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D066298" MajorTopicYN="N">In Vitro Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008213" MajorTopicYN="N">Lymphocyte Activation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008211" MajorTopicYN="N">Lymphocyte Cooperation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008808" MajorTopicYN="N">Mice, Inbred CBA</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1994</Year><Month>6</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1994</Year><Month>6</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1994</Year><Month>6</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7922370</ArticleId><ArticleId IdType="pii">S0960-9822(00)00110-X</ArticleId><ArticleId IdType="doi">10.1016/s0960-9822(00)00110-x</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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