H2N2V1, PubMed, Checkpoint, bibRecord, 000131

Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses.

Identifieur interne : 000131 ( PubMed/Checkpoint ); précédent : 000130; suivant : 000132

Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses.

Auteurs : Jens C. Krause [États-Unis] ; Tshidi Tsibane ; Terrence M. Tumpey ; Chelsey J. Huffman ; Randy Albrecht ; David L. Blum ; Irene Ramos ; Ana Fernandez-Sesma ; Kathryn M. Edwards ; Adolfo García-Sastre ; Christopher F. Basler ; James E. Crowe

Source :

Journal of virology [ 1098-5514 ] ; 2012.

RBID : pubmed:22457520

Descripteurs français

KwdFr :
- ARN viral (génétique), Adulte, Adulte d'âge moyen, Analyse de survie, Analyse de séquence d'ADN, Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (isolement et purification), Anticorps antiviraux (usage thérapeutique), Anticorps monoclonaux (immunologie), Anticorps monoclonaux (isolement et purification), Anticorps monoclonaux (usage thérapeutique), Données de séquences moléculaires, Embryon de poulet, Femelle, Glycoprotéine hémagglutinine du virus influenza (immunologie), Grippe humaine (immunologie), Grippe humaine (virologie), Humains, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (mortalité), Modèles animaux de maladie humaine, Mutation faux-sens, Souris, Souris de lignée BALB C, Sous-type H2N2 du virus de la grippe A (croissance et développement), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (croissance et développement), Sous-type H3N2 du virus de la grippe A (immunologie).
MESH :
- croissance et développement : Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
- génétique : ARN viral.
- immunologie : Anticorps antiviraux, Anticorps monoclonaux, Glycoprotéine hémagglutinine du virus influenza, Grippe humaine, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
- isolement et purification : Anticorps antiviraux, Anticorps monoclonaux.
- mortalité : Infections à Orthomyxoviridae.
- usage thérapeutique : Anticorps antiviraux, Anticorps monoclonaux.
- virologie : Grippe humaine.
- Adulte, Adulte d'âge moyen, Analyse de survie, Analyse de séquence d'ADN, Animaux, Données de séquences moléculaires, Embryon de poulet, Femelle, Humains, Infections à Orthomyxoviridae, Modèles animaux de maladie humaine, Mutation faux-sens, Souris, Souris de lignée BALB C.

English descriptors

KwdEn :
- Adult, Animals, Antibodies, Monoclonal (immunology), Antibodies, Monoclonal (isolation & purification), Antibodies, Monoclonal (therapeutic use), Antibodies, Viral (immunology), Antibodies, Viral (isolation & purification), Antibodies, Viral (therapeutic use), Chick Embryo, Disease Models, Animal, Female, Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A Virus, H2N2 Subtype (growth & development), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H3N2 Subtype (growth & development), Influenza A Virus, H3N2 Subtype (immunology), Influenza, Human (immunology), Influenza, Human (virology), Mice, Mice, Inbred BALB C, Middle Aged, Molecular Sequence Data, Mutation, Missense, Orthomyxoviridae Infections (mortality), Orthomyxoviridae Infections (prevention & control), RNA, Viral (genetics), Sequence Analysis, DNA, Survival Analysis.
MESH :
- chemical , genetics : RNA, Viral.
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Viral, Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , isolation & purification : Antibodies, Monoclonal, Antibodies, Viral.
- chemical , therapeutic use : Antibodies, Monoclonal, Antibodies, Viral.
- growth & development : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza, Human.
- mortality : Orthomyxoviridae Infections.
- prevention & control : Orthomyxoviridae Infections.
- virology : Influenza, Human.
- Adult, Animals, Chick Embryo, Disease Models, Animal, Female, Humans, Mice, Mice, Inbred BALB C, Middle Aged, Molecular Sequence Data, Mutation, Missense, Sequence Analysis, DNA, Survival Analysis.

Abstract

Investigation of the human antibody response to the 1957 pandemic H2N2 influenza A virus has been largely limited to serologic studies. We generated five influenza virus hemagglutinin (HA)-reactive human monoclonal antibodies (MAbs) by hybridoma technology from the peripheral blood of healthy donors who were born between 1950 and 1968. Two MAbs reacted with the pandemic H2N2 virus, two recognized the pandemic H3N2 virus, and remarkably, one reacted with both the pandemic H2N2 and H3N2 viruses. Each of these five naturally occurring MAbs displayed hemagglutination inhibition activity, suggesting specificity for the globular head domain of influenza virus HA. When incubated with virus, MAbs 8F8, 8M2, and 2G1 each elicited H2N2 escape mutations immediately adjacent to the receptor-binding domain on the HA globular head in embryonated chicken eggs. All H2N2-specific MAbs were able to inhibit a 2006 swine H2N3 influenza virus. MAbs 8M2 and 2G1 shared the V(H)1-69 germ line gene, but these antibodies were otherwise not genetically related. Each antibody was able to protect mice in a lethal H2N2 virus challenge. Thus, even 43 years after circulation of H2N2 viruses, these subjects possessed peripheral blood B cells encoding potent inhibiting antibodies specific for a conserved region on the globular head of the pandemic H2 HA.

DOI: 10.1128/JVI.07158-11
PubMed: 22457520

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000147
to stream PubMed, to step Curation: 000147

Links to Exploration step

pubmed:22457520

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses.</title>
<author><name sortKey="Krause, Jens C" sort="Krause, Jens C" uniqKey="Krause J" first="Jens C" last="Krause">Jens C. Krause</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tsibane, Tshidi" sort="Tsibane, Tshidi" uniqKey="Tsibane T" first="Tshidi" last="Tsibane">Tshidi Tsibane</name>
</author>
<author><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M" last="Tumpey">Terrence M. Tumpey</name>
</author>
<author><name sortKey="Huffman, Chelsey J" sort="Huffman, Chelsey J" uniqKey="Huffman C" first="Chelsey J" last="Huffman">Chelsey J. Huffman</name>
</author>
<author><name sortKey="Albrecht, Randy" sort="Albrecht, Randy" uniqKey="Albrecht R" first="Randy" last="Albrecht">Randy Albrecht</name>
</author>
<author><name sortKey="Blum, David L" sort="Blum, David L" uniqKey="Blum D" first="David L" last="Blum">David L. Blum</name>
</author>
<author><name sortKey="Ramos, Irene" sort="Ramos, Irene" uniqKey="Ramos I" first="Irene" last="Ramos">Irene Ramos</name>
</author>
<author><name sortKey="Fernandez Sesma, Ana" sort="Fernandez Sesma, Ana" uniqKey="Fernandez Sesma A" first="Ana" last="Fernandez-Sesma">Ana Fernandez-Sesma</name>
</author>
<author><name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M" last="Edwards">Kathryn M. Edwards</name>
</author>
<author><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name>
</author>
<author><name sortKey="Basler, Christopher F" sort="Basler, Christopher F" uniqKey="Basler C" first="Christopher F" last="Basler">Christopher F. Basler</name>
</author>
<author><name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E" last="Crowe">James E. Crowe</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2012">2012</date>
<idno type="RBID">pubmed:22457520</idno>
<idno type="pmid">22457520</idno>
<idno type="doi">10.1128/JVI.07158-11</idno>
<idno type="wicri:Area/PubMed/Corpus">000147</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000147</idno>
<idno type="wicri:Area/PubMed/Curation">000147</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000147</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000131</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000131</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses.</title>
<author><name sortKey="Krause, Jens C" sort="Krause, Jens C" uniqKey="Krause J" first="Jens C" last="Krause">Jens C. Krause</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tsibane, Tshidi" sort="Tsibane, Tshidi" uniqKey="Tsibane T" first="Tshidi" last="Tsibane">Tshidi Tsibane</name>
</author>
<author><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M" last="Tumpey">Terrence M. Tumpey</name>
</author>
<author><name sortKey="Huffman, Chelsey J" sort="Huffman, Chelsey J" uniqKey="Huffman C" first="Chelsey J" last="Huffman">Chelsey J. Huffman</name>
</author>
<author><name sortKey="Albrecht, Randy" sort="Albrecht, Randy" uniqKey="Albrecht R" first="Randy" last="Albrecht">Randy Albrecht</name>
</author>
<author><name sortKey="Blum, David L" sort="Blum, David L" uniqKey="Blum D" first="David L" last="Blum">David L. Blum</name>
</author>
<author><name sortKey="Ramos, Irene" sort="Ramos, Irene" uniqKey="Ramos I" first="Irene" last="Ramos">Irene Ramos</name>
</author>
<author><name sortKey="Fernandez Sesma, Ana" sort="Fernandez Sesma, Ana" uniqKey="Fernandez Sesma A" first="Ana" last="Fernandez-Sesma">Ana Fernandez-Sesma</name>
</author>
<author><name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M" last="Edwards">Kathryn M. Edwards</name>
</author>
<author><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name>
</author>
<author><name sortKey="Basler, Christopher F" sort="Basler, Christopher F" uniqKey="Basler C" first="Christopher F" last="Basler">Christopher F. Basler</name>
</author>
<author><name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E" last="Crowe">James E. Crowe</name>
</author>
</analytic>
<series><title level="j">Journal of virology</title>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2012" type="published">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Animals</term>
<term>Antibodies, Monoclonal (immunology)</term>
<term>Antibodies, Monoclonal (isolation & purification)</term>
<term>Antibodies, Monoclonal (therapeutic use)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Antibodies, Viral (isolation & purification)</term>
<term>Antibodies, Viral (therapeutic use)</term>
<term>Chick Embryo</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term>
<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype (growth & development)</term>
<term>Influenza A Virus, H2N2 Subtype (immunology)</term>
<term>Influenza A Virus, H3N2 Subtype (growth & development)</term>
<term>Influenza A Virus, H3N2 Subtype (immunology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (virology)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Middle Aged</term>
<term>Molecular Sequence Data</term>
<term>Mutation, Missense</term>
<term>Orthomyxoviridae Infections (mortality)</term>
<term>Orthomyxoviridae Infections (prevention & control)</term>
<term>RNA, Viral (genetics)</term>
<term>Sequence Analysis, DNA</term>
<term>Survival Analysis</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Analyse de séquence d'ADN</term>
<term>Animaux</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Anticorps antiviraux (isolement et purification)</term>
<term>Anticorps antiviraux (usage thérapeutique)</term>
<term>Anticorps monoclonaux (immunologie)</term>
<term>Anticorps monoclonaux (isolement et purification)</term>
<term>Anticorps monoclonaux (usage thérapeutique)</term>
<term>Données de séquences moléculaires</term>
<term>Embryon de poulet</term>
<term>Femelle</term>
<term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term>
<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Infections à Orthomyxoviridae (mortalité)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mutation faux-sens</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Sous-type H2N2 du virus de la grippe A (croissance et développement)</term>
<term>Sous-type H2N2 du virus de la grippe A (immunologie)</term>
<term>Sous-type H3N2 du virus de la grippe A (croissance et développement)</term>
<term>Sous-type H3N2 du virus de la grippe A (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Antibodies, Viral</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps monoclonaux</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Grippe humaine</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps monoclonaux</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps monoclonaux</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Animals</term>
<term>Chick Embryo</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Middle Aged</term>
<term>Molecular Sequence Data</term>
<term>Mutation, Missense</term>
<term>Sequence Analysis, DNA</term>
<term>Survival Analysis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Analyse de séquence d'ADN</term>
<term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Embryon de poulet</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mutation faux-sens</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Investigation of the human antibody response to the 1957 pandemic H2N2 influenza A virus has been largely limited to serologic studies. We generated five influenza virus hemagglutinin (HA)-reactive human monoclonal antibodies (MAbs) by hybridoma technology from the peripheral blood of healthy donors who were born between 1950 and 1968. Two MAbs reacted with the pandemic H2N2 virus, two recognized the pandemic H3N2 virus, and remarkably, one reacted with both the pandemic H2N2 and H3N2 viruses. Each of these five naturally occurring MAbs displayed hemagglutination inhibition activity, suggesting specificity for the globular head domain of influenza virus HA. When incubated with virus, MAbs 8F8, 8M2, and 2G1 each elicited H2N2 escape mutations immediately adjacent to the receptor-binding domain on the HA globular head in embryonated chicken eggs. All H2N2-specific MAbs were able to inhibit a 2006 swine H2N3 influenza virus. MAbs 8M2 and 2G1 shared the V(H)1-69 germ line gene, but these antibodies were otherwise not genetically related. Each antibody was able to protect mice in a lethal H2N2 virus challenge. Thus, even 43 years after circulation of H2N2 viruses, these subjects possessed peripheral blood B cells encoding potent inhibiting antibodies specific for a conserved region on the globular head of the pandemic H2 HA.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22457520</PMID>
<DateCompleted><Year>2012</Year>
<Month>07</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-5514</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>86</Volume>
<Issue>11</Issue>
<PubDate><Year>2012</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Journal of virology</Title>
<ISOAbbreviation>J. Virol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses.</ArticleTitle>
<Pagination><MedlinePgn>6334-40</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1128/JVI.07158-11</ELocationID>
<Abstract><AbstractText>Investigation of the human antibody response to the 1957 pandemic H2N2 influenza A virus has been largely limited to serologic studies. We generated five influenza virus hemagglutinin (HA)-reactive human monoclonal antibodies (MAbs) by hybridoma technology from the peripheral blood of healthy donors who were born between 1950 and 1968. Two MAbs reacted with the pandemic H2N2 virus, two recognized the pandemic H3N2 virus, and remarkably, one reacted with both the pandemic H2N2 and H3N2 viruses. Each of these five naturally occurring MAbs displayed hemagglutination inhibition activity, suggesting specificity for the globular head domain of influenza virus HA. When incubated with virus, MAbs 8F8, 8M2, and 2G1 each elicited H2N2 escape mutations immediately adjacent to the receptor-binding domain on the HA globular head in embryonated chicken eggs. All H2N2-specific MAbs were able to inhibit a 2006 swine H2N3 influenza virus. MAbs 8M2 and 2G1 shared the V(H)1-69 germ line gene, but these antibodies were otherwise not genetically related. Each antibody was able to protect mice in a lethal H2N2 virus challenge. Thus, even 43 years after circulation of H2N2 viruses, these subjects possessed peripheral blood B cells encoding potent inhibiting antibodies specific for a conserved region on the globular head of the pandemic H2 HA.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Krause</LastName>
<ForeName>Jens C</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Departments of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tsibane</LastName>
<ForeName>Tshidi</ForeName>
<Initials>T</Initials>
</Author>
<Author ValidYN="Y"><LastName>Tumpey</LastName>
<ForeName>Terrence M</ForeName>
<Initials>TM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Huffman</LastName>
<ForeName>Chelsey J</ForeName>
<Initials>CJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Albrecht</LastName>
<ForeName>Randy</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Blum</LastName>
<ForeName>David L</ForeName>
<Initials>DL</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ramos</LastName>
<ForeName>Irene</ForeName>
<Initials>I</Initials>
</Author>
<Author ValidYN="Y"><LastName>Fernandez-Sesma</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Edwards</LastName>
<ForeName>Kathryn M</ForeName>
<Initials>KM</Initials>
</Author>
<Author ValidYN="Y"><LastName>García-Sastre</LastName>
<ForeName>Adolfo</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Basler</LastName>
<ForeName>Christopher F</ForeName>
<Initials>CF</Initials>
</Author>
<Author ValidYN="Y"><LastName>Crowe</LastName>
<ForeName>James E</ForeName>
<Initials>JE</Initials>
<Suffix>Jr</Suffix>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName>
<AccessionNumberList><AccessionNumber>JN130388</AccessionNumber>
<AccessionNumber>JN130389</AccessionNumber>
<AccessionNumber>JN130390</AccessionNumber>
<AccessionNumber>JN130391</AccessionNumber>
<AccessionNumber>JN130392</AccessionNumber>
<AccessionNumber>JN130393</AccessionNumber>
<AccessionNumber>JN130394</AccessionNumber>
<AccessionNumber>JN130395</AccessionNumber>
<AccessionNumber>JN130396</AccessionNumber>
<AccessionNumber>JN130397</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<GrantList CompleteYN="Y"><Grant><GrantID>UL1RR029887</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>EY008126</GrantID>
<Acronym>EY</Acronym>
<Agency>NEI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P30 DK058404</GrantID>
<Acronym>DK</Acronym>
<Agency>NIDDK NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>TL1 RR024978</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>KL2 RR024977</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P30 EY008126</GrantID>
<Acronym>EY</Acronym>
<Agency>NEI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>UL1RR024975</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P30 CA068485</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>UL1 RR029887</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>UL1 RR024975</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>HHSN266200700010C</GrantID>
<Agency>PHS HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>CA068485</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>DK058404</GrantID>
<Acronym>DK</Acronym>
<Agency>NIDDK NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>HHSN266200700010C</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R21AI085306</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P01 AI058113</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R21 AI085306</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2012</Year>
<Month>03</Month>
<Day>28</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Virol</MedlineTA>
<NlmUniqueID>0113724</NlmUniqueID>
<ISSNLinking>0022-538X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002642" MajorTopicYN="N">Chick Embryo</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053121" MajorTopicYN="N">Influenza A Virus, H2N2 Subtype</DescriptorName>
<QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053122" MajorTopicYN="N">Influenza A Virus, H3N2 Subtype</DescriptorName>
<QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020125" MajorTopicYN="N">Mutation, Missense</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year>
<Month>3</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2012</Year>
<Month>3</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2012</Year>
<Month>7</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">22457520</ArticleId>
<ArticleId IdType="pii">JVI.07158-11</ArticleId>
<ArticleId IdType="doi">10.1128/JVI.07158-11</ArticleId>
<ArticleId IdType="pmc">PMC3372199</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Nucleic Acids Res. 2008 Jan;36(Database issue):D497-503</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17965094</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2011 Nov;85(21):11048-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21865387</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2008 Mar 1;197(5):667-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18260764</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2008 May 29;453(7195):667-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18449194</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W503-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18503082</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol Methods. 2008 Jul 31;336(2):142-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18514220</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2008 Sep 25;455(7212):532-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18716625</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Struct Mol Biol. 2009 Mar;16(3):265-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19234466</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2009 Mar;5(3):e1000350</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19300497</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2009 Apr 10;324(5924):246-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19251591</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2009 Jun 18;360(25):2605-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19423869</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2009 Oct 30;326(5953):734-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19900932</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2010 Feb;84(4):1715-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20007271</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2010 Feb 20;397(2):322-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19969317</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 2010 Mar 19;393(4):614-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20152806</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Virol. 2000;145(6):1059-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10948982</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2000 Sep;74(18):8502-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10954551</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2001 Oct;82(Pt 10):2475-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11562540</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2002 Aug 19;20(25-26):3068-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12163258</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med Microbiol Immunol. 2002 Dec;191(3-4):203-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12458361</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2004 Mar 19;303(5665):1866-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14764887</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1979 May 17;279(5710):246-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">86955</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1980 Jul 15;104(1):139-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6156537</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann N Y Acad Sci. 1980;354:142-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6164328</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1982 Sep;62 (Pt 1):153-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6182265</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 1982 Dec;31(2 Pt 1):417-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6186384</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Immunol. 1984 Jul;21(7):663-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6205255</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1984 Oct 30;138(2):276-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6208682</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Hyg (Lond). 1985 Oct;95(2):437-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4067298</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 1986 Feb;23(2):240-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3517049</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vopr Virusol. 1989 Sep-Oct;34(5):543-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2609638</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1993 May;67(5):2552-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7682624</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1993 Jun;194(2):781-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7684877</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1994 Nov 15;205(1):17-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7975212</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 1997 Aug;176 Suppl 1:S14-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9240688</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 1960 Nov 1;112:921-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">13693272</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunology. 2006 Sep;119(1):1-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16925526</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Jul;81(13):7111-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17475660</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioinformatics. 2007 Nov 1;23(21):2947-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17846036</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20949-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18093945</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2010 May;120(5):1663-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20389023</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2010 May 13;465(7295):161</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20463719</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Public Health Rep. 2010 Apr;125 Suppl 3:16-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20568566</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2010;5(6):e11158</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20574518</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2010;5(10):e13768</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21060797</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2011 Jan 17;208(1):181-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21220454</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2011 Feb;92(Pt 2):326-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21068214</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2011 Mar 10;471(7337):157-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21390107</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14216-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21825125</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2011 Oct 1;187(7):3704-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21880983</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2011 Oct;85(20):10905-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21849447</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbiol Immunol. 2008 Mar;52(3):162-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18402598</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Tennessee</li>
</region>
</list>
<tree><noCountry><name sortKey="Albrecht, Randy" sort="Albrecht, Randy" uniqKey="Albrecht R" first="Randy" last="Albrecht">Randy Albrecht</name>
<name sortKey="Basler, Christopher F" sort="Basler, Christopher F" uniqKey="Basler C" first="Christopher F" last="Basler">Christopher F. Basler</name>
<name sortKey="Blum, David L" sort="Blum, David L" uniqKey="Blum D" first="David L" last="Blum">David L. Blum</name>
<name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E" last="Crowe">James E. Crowe</name>
<name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M" last="Edwards">Kathryn M. Edwards</name>
<name sortKey="Fernandez Sesma, Ana" sort="Fernandez Sesma, Ana" uniqKey="Fernandez Sesma A" first="Ana" last="Fernandez-Sesma">Ana Fernandez-Sesma</name>
<name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name>
<name sortKey="Huffman, Chelsey J" sort="Huffman, Chelsey J" uniqKey="Huffman C" first="Chelsey J" last="Huffman">Chelsey J. Huffman</name>
<name sortKey="Ramos, Irene" sort="Ramos, Irene" uniqKey="Ramos I" first="Irene" last="Ramos">Irene Ramos</name>
<name sortKey="Tsibane, Tshidi" sort="Tsibane, Tshidi" uniqKey="Tsibane T" first="Tshidi" last="Tsibane">Tshidi Tsibane</name>
<name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M" last="Tumpey">Terrence M. Tumpey</name>
</noCountry>
<country name="États-Unis"><region name="Tennessee"><name sortKey="Krause, Jens C" sort="Krause, Jens C" uniqKey="Krause J" first="Jens C" last="Krause">Jens C. Krause</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000131 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000131 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:22457520
   |texte=   Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:22457520" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a H2N2V1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration H2N2

Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses.

Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki