H2N2V1, PubMed, Checkpoint, bibRecord, 000130

Influenza B-cells protective epitope characterization: a passkey for the rational design of new broad-range anti-influenza vaccines.

Identifieur interne : 000130 ( PubMed/Checkpoint ); précédent : 000129; suivant : 000131

Influenza B-cells protective epitope characterization: a passkey for the rational design of new broad-range anti-influenza vaccines.

Auteurs : Nicola Clementi [Italie] ; Elena Criscuolo ; Matteo Castelli ; Nicasio Mancini ; Massimo Clementi ; Roberto Burioni

Source :

Viruses [ 1999-4915 ] ; 2012.

RBID : pubmed:23202517

Descripteurs français

English descriptors

KwdEn :
- Animals, Antibodies, Monoclonal (immunology), Antibodies, Neutralizing (immunology), Antigens, Viral (chemistry), Antigens, Viral (immunology), B-Lymphocytes (immunology), Cross Reactions (immunology), Epitopes, B-Lymphocyte (chemistry), Epitopes, B-Lymphocyte (immunology), Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A virus (classification), Influenza A virus (genetics), Influenza A virus (immunology), Influenza Vaccines (immunology), Influenza, Human (immunology), Influenza, Human (prevention & control).
MESH :
- chemical , chemistry : Antigens, Viral, Epitopes, B-Lymphocyte, Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Neutralizing, Antigens, Viral, Epitopes, B-Lymphocyte, Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines.
- classification : Influenza A virus.
- genetics : Influenza A virus.
- immunology : B-Lymphocytes, Cross Reactions, Influenza A virus, Influenza, Human.
- prevention & control : Influenza, Human.
- Animals, Humans.

Abstract

The emergence of new influenza strains causing pandemics represents a serious threat to human health. From 1918, four influenza pandemics occurred, caused by H1N1, H2N2 and H3N2 subtypes. Moreover, in 1997 a novel influenza avian strain belonging to the H5N1 subtype infected humans. Nowadays, even if its transmission is still circumscribed to avian species, the capability of the virus to infect humans directly from avian reservoirs can result in fatalities. Moreover, the risk that this or novel avian strains could adapt to inter-human transmission, the development of resistance to anti-viral drugs and the lack of an effective prevention are all incumbent problems for the world population. In this scenario, the identification of broadly neutralizing monoclonal antibodies (mAbs) directed against conserved regions shared among influenza isolates has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" anti-influenza vaccines.

DOI: 10.3390/v4113090
PubMed: 23202517

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000133
to stream PubMed, to step Curation: 000133

Links to Exploration step

pubmed:23202517

Le document en format XML

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<front><div type="abstract" xml:lang="en">The emergence of new influenza strains causing pandemics represents a serious threat to human health. From 1918, four influenza pandemics occurred, caused by H1N1, H2N2 and H3N2 subtypes. Moreover, in 1997 a novel influenza avian strain belonging to the H5N1 subtype infected humans. Nowadays, even if its transmission is still circumscribed to avian species, the capability of the virus to infect humans directly from avian reservoirs can result in fatalities. Moreover, the risk that this or novel avian strains could adapt to inter-human transmission, the development of resistance to anti-viral drugs and the lack of an effective prevention are all incumbent problems for the world population. In this scenario, the identification of broadly neutralizing monoclonal antibodies (mAbs) directed against conserved regions shared among influenza isolates has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" anti-influenza vaccines.</div>
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Influenza B-cells protective epitope characterization: a passkey for the rational design of new broad-range anti-influenza vaccines.

Influenza B-cells protective epitope characterization: a passkey for the rational design of new broad-range anti-influenza vaccines.

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