Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses.
Identifieur interne : 000147 ( PubMed/Curation ); précédent : 000146; suivant : 000148Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses.
Auteurs : Jens C. Krause [États-Unis] ; Tshidi Tsibane ; Terrence M. Tumpey ; Chelsey J. Huffman ; Randy Albrecht ; David L. Blum ; Irene Ramos ; Ana Fernandez-Sesma ; Kathryn M. Edwards ; Adolfo García-Sastre ; Christopher F. Basler ; James E. CroweSource :
- Journal of virology [ 1098-5514 ] ; 2012.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Adulte, Adulte d'âge moyen, Analyse de survie, Analyse de séquence d'ADN, Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (isolement et purification), Anticorps antiviraux (usage thérapeutique), Anticorps monoclonaux (immunologie), Anticorps monoclonaux (isolement et purification), Anticorps monoclonaux (usage thérapeutique), Données de séquences moléculaires, Embryon de poulet, Femelle, Glycoprotéine hémagglutinine du virus influenza (immunologie), Grippe humaine (immunologie), Grippe humaine (virologie), Humains, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (mortalité), Modèles animaux de maladie humaine, Mutation faux-sens, Souris, Souris de lignée BALB C, Sous-type H2N2 du virus de la grippe A (croissance et développement), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (croissance et développement), Sous-type H3N2 du virus de la grippe A (immunologie).
- MESH :
- croissance et développement : Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
- génétique : ARN viral.
- immunologie : Anticorps antiviraux, Anticorps monoclonaux, Glycoprotéine hémagglutinine du virus influenza, Grippe humaine, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
- isolement et purification : Anticorps antiviraux, Anticorps monoclonaux.
- mortalité : Infections à Orthomyxoviridae.
- usage thérapeutique : Anticorps antiviraux, Anticorps monoclonaux.
- virologie : Grippe humaine.
- Adulte, Adulte d'âge moyen, Analyse de survie, Analyse de séquence d'ADN, Animaux, Données de séquences moléculaires, Embryon de poulet, Femelle, Humains, Infections à Orthomyxoviridae, Modèles animaux de maladie humaine, Mutation faux-sens, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Adult, Animals, Antibodies, Monoclonal (immunology), Antibodies, Monoclonal (isolation & purification), Antibodies, Monoclonal (therapeutic use), Antibodies, Viral (immunology), Antibodies, Viral (isolation & purification), Antibodies, Viral (therapeutic use), Chick Embryo, Disease Models, Animal, Female, Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A Virus, H2N2 Subtype (growth & development), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H3N2 Subtype (growth & development), Influenza A Virus, H3N2 Subtype (immunology), Influenza, Human (immunology), Influenza, Human (virology), Mice, Mice, Inbred BALB C, Middle Aged, Molecular Sequence Data, Mutation, Missense, Orthomyxoviridae Infections (mortality), Orthomyxoviridae Infections (prevention & control), RNA, Viral (genetics), Sequence Analysis, DNA, Survival Analysis.
- MESH :
- chemical , genetics : RNA, Viral.
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Viral, Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , isolation & purification : Antibodies, Monoclonal, Antibodies, Viral.
- chemical , therapeutic use : Antibodies, Monoclonal, Antibodies, Viral.
- growth & development : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza, Human.
- mortality : Orthomyxoviridae Infections.
- prevention & control : Orthomyxoviridae Infections.
- virology : Influenza, Human.
- Adult, Animals, Chick Embryo, Disease Models, Animal, Female, Humans, Mice, Mice, Inbred BALB C, Middle Aged, Molecular Sequence Data, Mutation, Missense, Sequence Analysis, DNA, Survival Analysis.
Abstract
Investigation of the human antibody response to the 1957 pandemic H2N2 influenza A virus has been largely limited to serologic studies. We generated five influenza virus hemagglutinin (HA)-reactive human monoclonal antibodies (MAbs) by hybridoma technology from the peripheral blood of healthy donors who were born between 1950 and 1968. Two MAbs reacted with the pandemic H2N2 virus, two recognized the pandemic H3N2 virus, and remarkably, one reacted with both the pandemic H2N2 and H3N2 viruses. Each of these five naturally occurring MAbs displayed hemagglutination inhibition activity, suggesting specificity for the globular head domain of influenza virus HA. When incubated with virus, MAbs 8F8, 8M2, and 2G1 each elicited H2N2 escape mutations immediately adjacent to the receptor-binding domain on the HA globular head in embryonated chicken eggs. All H2N2-specific MAbs were able to inhibit a 2006 swine H2N3 influenza virus. MAbs 8M2 and 2G1 shared the V(H)1-69 germ line gene, but these antibodies were otherwise not genetically related. Each antibody was able to protect mice in a lethal H2N2 virus challenge. Thus, even 43 years after circulation of H2N2 viruses, these subjects possessed peripheral blood B cells encoding potent inhibiting antibodies specific for a conserved region on the globular head of the pandemic H2 HA.
DOI: 10.1128/JVI.07158-11
PubMed: 22457520
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pubmed:22457520Le document en format XML
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<front><div type="abstract" xml:lang="en">Investigation of the human antibody response to the 1957 pandemic H2N2 influenza A virus has been largely limited to serologic studies. We generated five influenza virus hemagglutinin (HA)-reactive human monoclonal antibodies (MAbs) by hybridoma technology from the peripheral blood of healthy donors who were born between 1950 and 1968. Two MAbs reacted with the pandemic H2N2 virus, two recognized the pandemic H3N2 virus, and remarkably, one reacted with both the pandemic H2N2 and H3N2 viruses. Each of these five naturally occurring MAbs displayed hemagglutination inhibition activity, suggesting specificity for the globular head domain of influenza virus HA. When incubated with virus, MAbs 8F8, 8M2, and 2G1 each elicited H2N2 escape mutations immediately adjacent to the receptor-binding domain on the HA globular head in embryonated chicken eggs. All H2N2-specific MAbs were able to inhibit a 2006 swine H2N3 influenza virus. MAbs 8M2 and 2G1 shared the V(H)1-69 germ line gene, but these antibodies were otherwise not genetically related. Each antibody was able to protect mice in a lethal H2N2 virus challenge. Thus, even 43 years after circulation of H2N2 viruses, these subjects possessed peripheral blood B cells encoding potent inhibiting antibodies specific for a conserved region on the globular head of the pandemic H2 HA.</div>
</front>
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<DateCompleted><Year>2012</Year>
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<ArticleTitle>Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses.</ArticleTitle>
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<Abstract><AbstractText>Investigation of the human antibody response to the 1957 pandemic H2N2 influenza A virus has been largely limited to serologic studies. We generated five influenza virus hemagglutinin (HA)-reactive human monoclonal antibodies (MAbs) by hybridoma technology from the peripheral blood of healthy donors who were born between 1950 and 1968. Two MAbs reacted with the pandemic H2N2 virus, two recognized the pandemic H3N2 virus, and remarkably, one reacted with both the pandemic H2N2 and H3N2 viruses. Each of these five naturally occurring MAbs displayed hemagglutination inhibition activity, suggesting specificity for the globular head domain of influenza virus HA. When incubated with virus, MAbs 8F8, 8M2, and 2G1 each elicited H2N2 escape mutations immediately adjacent to the receptor-binding domain on the HA globular head in embryonated chicken eggs. All H2N2-specific MAbs were able to inhibit a 2006 swine H2N3 influenza virus. MAbs 8M2 and 2G1 shared the V(H)1-69 germ line gene, but these antibodies were otherwise not genetically related. Each antibody was able to protect mice in a lethal H2N2 virus challenge. Thus, even 43 years after circulation of H2N2 viruses, these subjects possessed peripheral blood B cells encoding potent inhibiting antibodies specific for a conserved region on the globular head of the pandemic H2 HA.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Krause</LastName>
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<AffiliationInfo><Affiliation>Departments of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.</Affiliation>
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<ForeName>Terrence M</ForeName>
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