Return of pandemic H1N1 influenza virus
Identifieur interne : 000161 ( Pmc/Curation ); précédent : 000160; suivant : 000162Return of pandemic H1N1 influenza virus
Auteurs : Hilda Sherbany [Israël] ; John Mccauley ; Tal Meningher [Israël] ; Musa Hindiyeh [Israël] ; Rita Dichtiar [Israël] ; Michal Perry Markovich [Israël] ; Ella Mendelson [Israël] ; Michal Mandelboim [Israël]Source :
- BMC Infectious Diseases [ 1471-2334 ] ; 2014.
Abstract
Influenza pandemics are usually caused by the re-assortment of several influenza viruses, results in the emergence of new influenza virus strains that can infect the entire population. These pandemic strains, as well as seasonal influenza viruses, are subjected to extensive antigenic change that has, so far, prevented the generation of a universal vaccine.
Samples of patients hospitalized due to infection with the pandemic H1N1 influenza virus (A(H1N1)pdm09) from 2009, when the virus first appeared, until 2013 were analyzed.
While many patients were hospitalized in 2009 due to infection with the pandemic H1N1 influenza virus, only small percentages of patients were hospitalized later in 2010–2012. Surprisingly, however in 2012–2013, we noticed that the percentages of patients hospitalized due to the pandemic H1N1 influenza infection increased significantly. Moreover, the ages of hospitalized patients differed throughout this entire period (2009–2013) and pregnant women were especially vulnerable to the infection.
High percentages of patients (especially pregnant women) were hospitalized in 2013 due to the A(H1N1)pdm09 infection, which may have been enabled by an antigenic drift from those which circulated at the onset of the pandemic.
The online version of this article (doi:10.1186/s12879-014-0710-1) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12879-014-0710-1
PubMed: 25551676
PubMed Central: 4375933
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John Mccauley<affiliation><nlm:aff id="Aff2">WHO Collaborating Centre for Reference and Research on Influenza, Division of Virology, MRC National Institute for Medical Research, Mill Hill, London, NW7 1AA UK</nlm:aff>
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</affiliation>
Le document en format XML
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Influenza pandemics are usually caused by the re-assortment of several influenza viruses, results in the emergence of new influenza virus strains that can infect the entire population. These pandemic strains, as well as seasonal influenza viruses, are subjected to extensive antigenic change that has, so far, prevented the generation of a universal vaccine.</p>
</sec>
<sec><title>Methods</title>
<p>Samples of patients hospitalized due to infection with the pandemic H1N1 influenza virus (A(H1N1)pdm09) from 2009, when the virus first appeared, until 2013 were analyzed.</p>
</sec>
<sec><title>Results</title>
<p>While many patients were hospitalized in 2009 due to infection with the pandemic H1N1 influenza virus, only small percentages of patients were hospitalized later in 2010–2012. Surprisingly, however in 2012–2013, we noticed that the percentages of patients hospitalized due to the pandemic H1N1 influenza infection increased significantly. Moreover, the ages of hospitalized patients differed throughout this entire period (2009–2013) and pregnant women were especially vulnerable to the infection.</p>
</sec>
<sec><title>Conclusions</title>
<p>High percentages of patients (especially pregnant women) were hospitalized in 2013 due to the A(H1N1)pdm09 infection, which may have been enabled by an antigenic drift from those which circulated at the onset of the pandemic.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s12879-014-0710-1) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">BMC Infect. Dis</journal-id>
<journal-title-group><journal-title>BMC Infectious Diseases</journal-title>
</journal-title-group>
<issn pub-type="epub">1471-2334</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25551676</article-id>
<article-id pub-id-type="pmc">4375933</article-id>
<article-id pub-id-type="publisher-id">710</article-id>
<article-id pub-id-type="doi">10.1186/s12879-014-0710-1</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Return of pandemic H1N1 influenza virus</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Sherbany</surname>
<given-names>Hilda</given-names>
</name>
<address><email>hilda.sherbany@sheba.health.gov.il</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>McCauley</surname>
<given-names>John</given-names>
</name>
<address><email>jmccaul@nimr.mrc.ac.uk</email>
</address>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meningher</surname>
<given-names>Tal</given-names>
</name>
<address><email>talsegman@gmail.com</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
<xref ref-type="aff" rid="Aff3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hindiyeh</surname>
<given-names>Musa</given-names>
</name>
<address><email>musa.hindiyeh@sheba.health.gov.il</email>
</address>
<xref ref-type="aff" rid="Aff3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dichtiar</surname>
<given-names>Rita</given-names>
</name>
<address><email>Rita.Dichtiar@MOH.HEALTH.GOV.IL</email>
</address>
<xref ref-type="aff" rid="Aff4"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Markovich</surname>
<given-names>Michal Perry</given-names>
</name>
<address><email>Michal.Perry@MOH.HEALTH.GOV.IL</email>
</address>
<xref ref-type="aff" rid="Aff4"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mendelson</surname>
<given-names>Ella</given-names>
</name>
<address><email>ella.mendelson@sheba.health.gov.il</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
<xref ref-type="aff" rid="Aff5"></xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Mandelboim</surname>
<given-names>Michal</given-names>
</name>
<address><email>michal.mandelboim@sheba.health.gov.il</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<aff id="Aff1"><label></label>
Central Virology Laboratory, Ministry of Health, Public Health Services, Chaim Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel</aff>
<aff id="Aff2"><label></label>
WHO Collaborating Centre for Reference and Research on Influenza, Division of Virology, MRC National Institute for Medical Research, Mill Hill, London, NW7 1AA UK</aff>
<aff id="Aff3"><label></label>
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel</aff>
<aff id="Aff4"><label></label>
Israel Center for Disease Control, Ministry of Health, Gertner Institute for Health Policy Research, Chaim Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel</aff>
<aff id="Aff5"><label></label>
Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel</aff>
</contrib-group>
<pub-date pub-type="epub"><day>31</day>
<month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>31</day>
<month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<volume>14</volume>
<elocation-id>710</elocation-id>
<history><date date-type="received"><day>29</day>
<month>6</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>11</day>
<month>12</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© Sherbany et al.; licensee BioMed Central. 2014</copyright-statement>
<license license-type="open-access"><license-p>This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p>Influenza pandemics are usually caused by the re-assortment of several influenza viruses, results in the emergence of new influenza virus strains that can infect the entire population. These pandemic strains, as well as seasonal influenza viruses, are subjected to extensive antigenic change that has, so far, prevented the generation of a universal vaccine.</p>
</sec>
<sec><title>Methods</title>
<p>Samples of patients hospitalized due to infection with the pandemic H1N1 influenza virus (A(H1N1)pdm09) from 2009, when the virus first appeared, until 2013 were analyzed.</p>
</sec>
<sec><title>Results</title>
<p>While many patients were hospitalized in 2009 due to infection with the pandemic H1N1 influenza virus, only small percentages of patients were hospitalized later in 2010–2012. Surprisingly, however in 2012–2013, we noticed that the percentages of patients hospitalized due to the pandemic H1N1 influenza infection increased significantly. Moreover, the ages of hospitalized patients differed throughout this entire period (2009–2013) and pregnant women were especially vulnerable to the infection.</p>
</sec>
<sec><title>Conclusions</title>
<p>High percentages of patients (especially pregnant women) were hospitalized in 2013 due to the A(H1N1)pdm09 infection, which may have been enabled by an antigenic drift from those which circulated at the onset of the pandemic.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s12879-014-0710-1) contains supplementary material, which is available to authorized users.</p>
</sec>
</abstract>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2014</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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