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Sialic acid tissue distribution and influenza virus tropism

Identifieur interne : 000081 ( Pmc/Curation ); précédent : 000080; suivant : 000082

Sialic acid tissue distribution and influenza virus tropism

Auteurs : Urban Kumlin ; Sigvard Olofsson ; Ken Dimock ; Niklas Arnberg

Source :

RBID : PMC:4941897

Abstract

Abstract  Avian influenza A viruses exhibit a strong preference for using α2,3‐linked sialic acid as a receptor. Until recently, the presumed lack of this receptor in human airways was believed to constitute an efficient barrier to avian influenza A virus infection of humans. Recent zoonotic outbreaks of avian influenza A virus have triggered researchers to analyse tissue distribution of sialic acid in further detail. Here, we review and extend the current knowledge about sialic acid distribution in human tissues, and discuss viruses with ocular tropism and their preference for α2,3‐linked sialic acid.


Url:
DOI: 10.1111/j.1750-2659.2008.00051.x
PubMed: 19453419
PubMed Central: 4941897

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PMC:4941897

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Avian influenza A viruses exhibit a strong preference for using α2,3‐linked sialic acid as a receptor. Until recently, the presumed lack of this receptor in human airways was believed to constitute an efficient barrier to avian influenza A virus infection of humans. Recent zoonotic outbreaks of avian influenza A virus have triggered researchers to analyse tissue distribution of sialic acid in further detail. Here, we review and extend the current knowledge about sialic acid distribution in human tissues, and discuss viruses with ocular tropism and their preference for α2,3‐linked sialic acid.</p>
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Division of Virology, Department of Clinical Microbiology, Umeå University, Umeå, Sweden.</aff>
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Department of Clinical Virology, University of Göteborg, Göteborg, Sweden.</aff>
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Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.</aff>
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Avian influenza A viruses exhibit a strong preference for using α2,3‐linked sialic acid as a receptor. Until recently, the presumed lack of this receptor in human airways was believed to constitute an efficient barrier to avian influenza A virus infection of humans. Recent zoonotic outbreaks of avian influenza A virus have triggered researchers to analyse tissue distribution of sialic acid in further detail. Here, we review and extend the current knowledge about sialic acid distribution in human tissues, and discuss viruses with ocular tropism and their preference for α2,3‐linked sialic acid.</p>
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