Development of a new candidate H5N1 avian influenza virus for pre‐pandemic vaccine production
Identifieur interne : 000067 ( Pmc/Curation ); précédent : 000066; suivant : 000068Development of a new candidate H5N1 avian influenza virus for pre‐pandemic vaccine production
Auteurs : Jie Dong ; Yumiko Matsuoka ; Taronna R. Maines ; David E. Swayne ; Eduardo O Eill ; C. Todd Davis ; Neal Van-Hoven ; Amanda Balish ; Hong-Jie Yu ; Jacqueline M. Katz ; Alexander Klimov ; Nancy Cox ; De-Xin Li ; Yu Wang ; Yuan-Ji Guo ; Wei-Zhong Yang ; Ruben O. Donis ; Yue-Long ShuSource :
- Influenza and Other Respiratory Viruses [ 1750-2640 ] ; 2009.
Abstract
Url:
DOI: 10.1111/j.1750-2659.2009.00104.x
PubMed: 19903211
PubMed Central: 4941393
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Swayne</name><affiliation><nlm:aff id="a3"></nlm:aff></affiliation></author><author><name sortKey="O Eill, Eduardo" sort="O Eill, Eduardo" uniqKey="O Eill E" first="Eduardo" last="O Eill">Eduardo O Eill</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Davis, C Todd" sort="Davis, C Todd" uniqKey="Davis C" first="C. Todd" last="Davis">C. Todd Davis</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Van Oven, Neal" sort="Van Oven, Neal" uniqKey="Van Oven N" first="Neal" last="Van-Hoven">Neal Van-Hoven</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Balish, Amanda" sort="Balish, Amanda" uniqKey="Balish A" first="Amanda" last="Balish">Amanda Balish</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Yu, Hong Ie" sort="Yu, Hong Ie" uniqKey="Yu H" first="Hong-Jie" last="Yu">Hong-Jie Yu</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Klimov, Alexander" sort="Klimov, Alexander" uniqKey="Klimov A" first="Alexander" last="Klimov">Alexander Klimov</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Cox, Nancy" sort="Cox, Nancy" uniqKey="Cox N" first="Nancy" last="Cox">Nancy Cox</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Li, De In" sort="Li, De In" uniqKey="Li D" first="De-Xin" last="Li">De-Xin Li</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Wang, Yu" sort="Wang, Yu" uniqKey="Wang Y" first="Yu" last="Wang">Yu Wang</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Guo, Yuan I" sort="Guo, Yuan I" uniqKey="Guo Y" first="Yuan-Ji" last="Guo">Yuan-Ji Guo</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Yang, Wei Hong" sort="Yang, Wei Hong" uniqKey="Yang W" first="Wei-Zhong" last="Yang">Wei-Zhong Yang</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Donis, Ruben O" sort="Donis, Ruben O" uniqKey="Donis R" first="Ruben O." last="Donis">Ruben O. Donis</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Shu, Yue Ong" sort="Shu, Yue Ong" uniqKey="Shu Y" first="Yue-Long" last="Shu">Yue-Long Shu</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19903211</idno><idno type="pmc">4941393</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941393</idno><idno type="RBID">PMC:4941393</idno><idno type="doi">10.1111/j.1750-2659.2009.00104.x</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000067</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000067</idno><idno type="wicri:Area/Pmc/Curation">000067</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000067</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Development of a new candidate H5N1 avian influenza virus for pre‐pandemic vaccine production</title><author><name sortKey="Dong, Jie" sort="Dong, Jie" uniqKey="Dong J" first="Jie" last="Dong">Jie Dong</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Matsuoka, Yumiko" sort="Matsuoka, Yumiko" uniqKey="Matsuoka Y" first="Yumiko" last="Matsuoka">Yumiko Matsuoka</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Maines, Taronna R" sort="Maines, Taronna R" uniqKey="Maines T" first="Taronna R." last="Maines">Taronna R. Maines</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Swayne, David E" sort="Swayne, David E" uniqKey="Swayne D" first="David E." last="Swayne">David E. Swayne</name><affiliation><nlm:aff id="a3"></nlm:aff></affiliation></author><author><name sortKey="O Eill, Eduardo" sort="O Eill, Eduardo" uniqKey="O Eill E" first="Eduardo" last="O Eill">Eduardo O Eill</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Davis, C Todd" sort="Davis, C Todd" uniqKey="Davis C" first="C. Todd" last="Davis">C. Todd Davis</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Van Oven, Neal" sort="Van Oven, Neal" uniqKey="Van Oven N" first="Neal" last="Van-Hoven">Neal Van-Hoven</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Balish, Amanda" sort="Balish, Amanda" uniqKey="Balish A" first="Amanda" last="Balish">Amanda Balish</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Yu, Hong Ie" sort="Yu, Hong Ie" uniqKey="Yu H" first="Hong-Jie" last="Yu">Hong-Jie Yu</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Klimov, Alexander" sort="Klimov, Alexander" uniqKey="Klimov A" first="Alexander" last="Klimov">Alexander Klimov</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Cox, Nancy" sort="Cox, Nancy" uniqKey="Cox N" first="Nancy" last="Cox">Nancy Cox</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Li, De In" sort="Li, De In" uniqKey="Li D" first="De-Xin" last="Li">De-Xin Li</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Wang, Yu" sort="Wang, Yu" uniqKey="Wang Y" first="Yu" last="Wang">Yu Wang</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Guo, Yuan I" sort="Guo, Yuan I" uniqKey="Guo Y" first="Yuan-Ji" last="Guo">Yuan-Ji Guo</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Yang, Wei Hong" sort="Yang, Wei Hong" uniqKey="Yang W" first="Wei-Zhong" last="Yang">Wei-Zhong Yang</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author><author><name sortKey="Donis, Ruben O" sort="Donis, Ruben O" uniqKey="Donis R" first="Ruben O." last="Donis">Ruben O. Donis</name><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Shu, Yue Ong" sort="Shu, Yue Ong" uniqKey="Shu Y" first="Yue-Long" last="Shu">Yue-Long Shu</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation></author></analytic><series><title level="j">Influenza and Other Respiratory Viruses</title><idno type="ISSN">1750-2640</idno><idno type="eISSN">1750-2659</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background </bold> Highly pathogenic H5N1 avian influenza viruses currently circulating in birds have caused hundreds of human infections, and pose a significant pandemic threat. Vaccines are a major component of the public health preparedness for this likely event. The rapid evolution of H5N1 viruses has resulted in the emergence of multiple clades with distinct antigenic characteristics that require clade‐specific vaccines. A variant H5N1 virus termed clade 2.3.4 emerged in 2005 and has caused multiple fatal infections. Vaccine candidates that match the antigenic properties of variant viruses are necessary because inactivated influenza vaccines elicit strain‐specific protection.</p><p><bold>Objective </bold> To address the need for a suitable seed for manufacturing a clade 2.3.4 vaccine, we developed a new H5N1 pre‐pandemic candidate vaccine by reverse genetics and evaluated its safety and replication <italic>in vitro</italic> and <italic>in vivo</italic>.</p><p><bold>Methods </bold> A reassortant virus termed, Anhui/PR8, was produced by reverse genetics in compliance with WHO pandemic vaccine development guidelines and contains six genes from A/Puerto Rico/8/34 as well as the neuraminidase and hemagglutinin (HA) genomic segments from the A/Anhui/01/2005 virus. The multi‐basic cleavage site of HA was removed to reduce virulence.</p><p><bold>Results </bold> The reassortant Anhui/PR8 grows well in eggs and is avirulent to chicken and ferrets but retains the antigenicity of the parental A/Anhui/01/2005 virus.</p><p><bold>Conclusion </bold> These results indicate that the Anhui/PR8 reassortant lost a major virulent determinant and it is suitable for its use in vaccine manufacturing and as a reference vaccine virus against the H5N1 clade 2.3.4 viruses circulating in eastern China, Vietnam, Thailand, and Laos.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Influenza Other Respir Viruses</journal-id><journal-id journal-id-type="iso-abbrev">Influenza Other Respir Viruses</journal-id><journal-id journal-id-type="doi">10.1111/(ISSN)1750-2659</journal-id><journal-id journal-id-type="publisher-id">IRV</journal-id><journal-title-group><journal-title>Influenza and Other Respiratory Viruses</journal-title></journal-title-group><issn pub-type="ppub">1750-2640</issn><issn pub-type="epub">1750-2659</issn><publisher><publisher-name>Blackwell Publishing Ltd</publisher-name><publisher-loc>Oxford, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19903211</article-id><article-id pub-id-type="pmc">4941393</article-id><article-id pub-id-type="doi">10.1111/j.1750-2659.2009.00104.x</article-id><article-id pub-id-type="publisher-id">IRV104</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Development of a new candidate H5N1 avian influenza virus for pre‐pandemic vaccine production</article-title><alt-title alt-title-type="left-running-head">Dong <italic>et al.</italic></alt-title><alt-title alt-title-type="right-running-head">Anhui/PR8 candidate vaccine virus derivation</alt-title></title-group><contrib-group><contrib id="cr1" contrib-type="author"><name><surname>Dong</surname><given-names>Jie</given-names></name><xref ref-type="aff" rid="a1"><sup>1</sup></xref></contrib><contrib id="cr2" contrib-type="author"><name><surname>Matsuoka</surname><given-names>Yumiko</given-names></name><xref ref-type="aff" rid="a2"><sup>2</sup></xref></contrib><contrib id="cr3" contrib-type="author"><name><surname>Maines</surname><given-names>Taronna R.</given-names></name><xref ref-type="aff" rid="a2"><sup>2</sup></xref></contrib><contrib id="cr4" contrib-type="author"><name><surname>Swayne</surname><given-names>David E.</given-names></name><xref ref-type="aff" rid="a3"><sup>3</sup></xref></contrib><contrib id="cr5" contrib-type="author"><name><surname>O’Neill</surname><given-names>Eduardo</given-names></name><xref ref-type="aff" rid="a2"><sup>2</sup></xref></contrib><contrib id="cr6" contrib-type="author"><name><surname>Davis</surname><given-names>C. Todd</given-names></name><xref ref-type="aff" rid="a2"><sup>2</sup></xref></contrib><contrib id="cr7" contrib-type="author"><name><surname>Van‐Hoven</surname><given-names>Neal</given-names></name><xref ref-type="aff" rid="a2"><sup>2</sup></xref></contrib><contrib id="cr8" contrib-type="author"><name><surname>Balish</surname><given-names>Amanda</given-names></name><xref ref-type="aff" rid="a2"><sup>2</sup></xref></contrib><contrib id="cr9" contrib-type="author"><name><surname>Yu</surname><given-names>Hong‐jie</given-names></name><xref ref-type="aff" rid="a1"><sup>1</sup></xref></contrib><contrib id="cr10" contrib-type="author"><name><surname>Katz</surname><given-names>Jacqueline M.</given-names></name><xref ref-type="aff" rid="a2"><sup>2</sup></xref></contrib><contrib id="cr11" contrib-type="author"><name><surname>Klimov</surname><given-names>Alexander</given-names></name><xref ref-type="aff" rid="a2"><sup>2</sup></xref></contrib><contrib id="cr12" contrib-type="author"><name><surname>Cox</surname><given-names>Nancy</given-names></name><xref ref-type="aff" rid="a2"><sup>2</sup></xref></contrib><contrib id="cr13" contrib-type="author"><name><surname>Li</surname><given-names>De‐xin</given-names></name><xref ref-type="aff" rid="a1"><sup>1</sup></xref></contrib><contrib id="cr14" contrib-type="author"><name><surname>Wang</surname><given-names>Yu</given-names></name><xref ref-type="aff" rid="a1"><sup>1</sup></xref></contrib><contrib id="cr15" contrib-type="author"><name><surname>Guo</surname><given-names>Yuan‐ji</given-names></name><xref ref-type="aff" rid="a1"><sup>1</sup></xref></contrib><contrib id="cr16" contrib-type="author"><name><surname>Yang</surname><given-names>Wei‐zhong</given-names></name><xref ref-type="aff" rid="a1"><sup>1</sup></xref></contrib><contrib id="cr17" contrib-type="author"><name><surname>Donis</surname><given-names>Ruben O.</given-names></name><xref ref-type="aff" rid="a2"><sup>2</sup></xref></contrib><contrib id="cr18" contrib-type="author"><name><surname>Shu</surname><given-names>Yue‐long</given-names></name><xref ref-type="aff" rid="a1"><sup>1</sup></xref></contrib></contrib-group><aff id="a1"><label><sup>1</sup></label>Chinese National Influenza Center, State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, China CDC, Xuanwu District Beijing, China</aff><aff id="a2"><label><sup>2</sup></label>Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA</aff><aff id="a3"><label><sup>3</sup></label>Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Athens, GA, USA</aff><author-notes><corresp id="correspondenceTo">Dr. Ruben O. Donis, Influenza Division, NCIRD, CCID, Centers for Disease Control and Prevention, 1600 Clifton Road ‐ Mail Stop G‐16 Atlanta, GA 30333, USA. E‐mail: <email>rdonis@cdc.gov</email></corresp></author-notes><pub-date pub-type="epub"><day>22</day><month>10</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2009</year></pub-date><volume>3</volume><issue>6</issue><issue-id pub-id-type="doi">10.1111/irv.2009.3.issue-6</issue-id><fpage>287</fpage><lpage>295</lpage><history>Accepted 19 August 2009. Published Online 9 October 2009.</history><permissions><copyright-statement content-type="article-copyright">© 2009 Blackwell Publishing Ltd</copyright-statement></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="file:IRV-3-287.pdf"></self-uri><abstract><p><bold>Background </bold> Highly pathogenic H5N1 avian influenza viruses currently circulating in birds have caused hundreds of human infections, and pose a significant pandemic threat. Vaccines are a major component of the public health preparedness for this likely event. The rapid evolution of H5N1 viruses has resulted in the emergence of multiple clades with distinct antigenic characteristics that require clade‐specific vaccines. A variant H5N1 virus termed clade 2.3.4 emerged in 2005 and has caused multiple fatal infections. Vaccine candidates that match the antigenic properties of variant viruses are necessary because inactivated influenza vaccines elicit strain‐specific protection.</p><p><bold>Objective </bold> To address the need for a suitable seed for manufacturing a clade 2.3.4 vaccine, we developed a new H5N1 pre‐pandemic candidate vaccine by reverse genetics and evaluated its safety and replication <italic>in vitro</italic> and <italic>in vivo</italic>.</p><p><bold>Methods </bold> A reassortant virus termed, Anhui/PR8, was produced by reverse genetics in compliance with WHO pandemic vaccine development guidelines and contains six genes from A/Puerto Rico/8/34 as well as the neuraminidase and hemagglutinin (HA) genomic segments from the A/Anhui/01/2005 virus. The multi‐basic cleavage site of HA was removed to reduce virulence.</p><p><bold>Results </bold> The reassortant Anhui/PR8 grows well in eggs and is avirulent to chicken and ferrets but retains the antigenicity of the parental A/Anhui/01/2005 virus.</p><p><bold>Conclusion </bold> These results indicate that the Anhui/PR8 reassortant lost a major virulent determinant and it is suitable for its use in vaccine manufacturing and as a reference vaccine virus against the H5N1 clade 2.3.4 viruses circulating in eastern China, Vietnam, Thailand, and Laos.</p></abstract><kwd-group><kwd id="k1">Pandemic influenza</kwd><kwd id="k2">H5N1 vaccine</kwd><kwd id="k3">seed virus</kwd></kwd-group><counts><fig-count count="1"></fig-count><table-count count="6"></table-count><page-count count="9"></page-count></counts><custom-meta-group><custom-meta><meta-name>source-schema-version-number</meta-name><meta-value>2.0</meta-value></custom-meta><custom-meta><meta-name>cover-date</meta-name><meta-value>November 2009</meta-value></custom-meta><custom-meta><meta-name>details-of-publishers-convertor</meta-name><meta-value>Converter:WILEY_ML3GV2_TO_NLMPMC version:4.6.9 mode:remove_FC converted:04.11.2015</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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