Prior infection with classical swine H1N1 influenza viruses is associated with protective immunity to the 2009 pandemic H1N1 virus
Identifieur interne : 000068 ( Pmc/Curation ); précédent : 000067; suivant : 000069Prior infection with classical swine H1N1 influenza viruses is associated with protective immunity to the 2009 pandemic H1N1 virus
Auteurs : John C. Kash ; Li Qi ; Vivien G. Dugan ; Brett W. Jagger ; Rachel J. Hrabal ; Matthew J. Memoli ; David M. Morens ; Jeffery K. TaubenbergerSource :
- Influenza and Other Respiratory Viruses [ 1750-2640 ] ; 2010.
Abstract
Url:
DOI: 10.1111/j.1750-2659.2010.00132.x
PubMed: 20409208
PubMed Central: 2859467
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prior infection with classical swine H1N1 influenza viruses is associated with protective immunity to the 2009 pandemic H1N1 virus</title>
<author><name sortKey="Kash, John C" sort="Kash, John C" uniqKey="Kash J" first="John C." last="Kash">John C. Kash</name>
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<author><name sortKey="Hrabal, Rachel J" sort="Hrabal, Rachel J" uniqKey="Hrabal R" first="Rachel J." last="Hrabal">Rachel J. Hrabal</name>
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<author><name sortKey="Memoli, Matthew J" sort="Memoli, Matthew J" uniqKey="Memoli M" first="Matthew J." last="Memoli">Matthew J. Memoli</name>
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<series><title level="j">Influenza and Other Respiratory Viruses</title>
<idno type="ISSN">1750-2640</idno>
<idno type="eISSN">1750-2659</idno>
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<front><div type="abstract" xml:lang="en"><p><italic>Please cite this paper as:</italic>
Kash <italic>et al.</italic>
(2010) Prior infection with classical swine H1N1 influenza viruses is associated with protective immunity to the 2009 pandemic H1N1 virus. Influenza and Other Respiratory Viruses 4(3), 121–127.</p>
<p><bold>Background </bold>
The 2009 H1N1 pandemic emerged even though seasonal H1N1 viruses have circulated for decades. Epidemio‐logical evidence suggested that the current seasonal vaccine did not offer significant protection from the novel pandemic, and that people over the age of 50 might were less susceptible to infection.</p>
<p><bold>Objectives </bold>
In a mouse challenge study with the 2009 pandemic H1N1 virus, we evaluated protective immune responses elicited by prior infection with human and swine influenza A viruses.</p>
<p><bold>Results </bold>
Mice infected with A/Mexico/4108/2009 (Mex09) showed significant weight loss and 40% mortality. Prior infection with a 1976 classical swine H1N1 virus resulted in complete protection from Mex09 challenge. Prior infection with either a 2009 or a 1940 seasonal H1N1 influenza virus provided partial protection and a >100‐fold reduction in viral lung titers at day 4 post‐infection.</p>
<p><bold>Conclusions </bold>
These findings indicate that in experimental animals recently induced immunity to 1918‐derived H1N1 seasonal influenza viruses, and to a 1976 swine influenza virus, afford a degree of protection against the 2009 pandemic virus. Implications of these findings are discussed in the context of accumulating data suggesting partial protection of older persons during the 2009 pandemic.</p>
</div>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Influenza Other Respir Viruses</journal-id>
<journal-id journal-id-type="iso-abbrev">Influenza Other Respir Viruses</journal-id>
<journal-id journal-id-type="doi">10.1111/(ISSN)1750-2659</journal-id>
<journal-id journal-id-type="publisher-id">IRV</journal-id>
<journal-title-group><journal-title>Influenza and Other Respiratory Viruses</journal-title>
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<issn pub-type="ppub">1750-2640</issn>
<issn pub-type="epub">1750-2659</issn>
<publisher><publisher-name>Blackwell Publishing Ltd</publisher-name>
<publisher-loc>Oxford, UK</publisher-loc>
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<article-meta><article-id pub-id-type="pmid">20409208</article-id>
<article-id pub-id-type="pmc">2859467</article-id>
<article-id pub-id-type="doi">10.1111/j.1750-2659.2010.00132.x</article-id>
<article-id pub-id-type="publisher-id">IRV132</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Prior infection with classical swine H1N1 influenza viruses is associated with protective immunity to the 2009 pandemic H1N1 virus</article-title>
<alt-title alt-title-type="left-running-head">Kash <italic>et al.</italic>
</alt-title>
<alt-title alt-title-type="right-running-head">Protective immunity to 2009 pandemic H1N1 virus</alt-title>
</title-group>
<contrib-group><contrib id="cr1" contrib-type="author"><name><surname>Kash</surname>
<given-names>John C.</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr2" contrib-type="author"><name><surname>Qi</surname>
<given-names>Li</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr3" contrib-type="author"><name><surname>Dugan</surname>
<given-names>Vivien G.</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr4" contrib-type="author"><name><surname>Jagger</surname>
<given-names>Brett W.</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr5" contrib-type="author"><name><surname>Hrabal</surname>
<given-names>Rachel J.</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr6" contrib-type="author"><name><surname>Memoli</surname>
<given-names>Matthew J.</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr7" contrib-type="author"><name><surname>Morens</surname>
<given-names>David M.</given-names>
</name>
<xref ref-type="aff" rid="a2"><sup>2</sup>
</xref>
</contrib>
<contrib id="cr8" contrib-type="author"><name><surname>Taubenberger</surname>
<given-names>Jeffery K.</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
</contrib-group>
<aff id="a1"><label><sup>1</sup>
</label>
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Bethesda, MD, USA.</aff>
<aff id="a2"><label><sup>2</sup>
</label>
The Office of the Director, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.</aff>
<author-notes><corresp id="correspondenceTo">Jeffery K. Taubenberger, MD, PhD, Laboratory of Infectious Diseases, NIAID, NIH, 33 North Drive, MSC 3203, Bethesda, MD 20892‐3203, USA. E‐mail: <email>taubenbergerj@niaid.nih.gov</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>08</day>
<month>3</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><month>5</month>
<year>2010</year>
</pub-date>
<volume>4</volume>
<issue>3</issue>
<issue-id pub-id-type="doi">10.1111/irv.2010.4.issue-3</issue-id>
<fpage>121</fpage>
<lpage>127</lpage>
<history>Accepted 18 January 2010. Published Online 8 March 2010.</history>
<permissions><copyright-statement content-type="article-copyright">Published 2010. This article is a US Government work and is in the public domain in the USA</copyright-statement>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="file:IRV-4-121.pdf"></self-uri>
<abstract><p><italic>Please cite this paper as:</italic>
Kash <italic>et al.</italic>
(2010) Prior infection with classical swine H1N1 influenza viruses is associated with protective immunity to the 2009 pandemic H1N1 virus. Influenza and Other Respiratory Viruses 4(3), 121–127.</p>
<p><bold>Background </bold>
The 2009 H1N1 pandemic emerged even though seasonal H1N1 viruses have circulated for decades. Epidemio‐logical evidence suggested that the current seasonal vaccine did not offer significant protection from the novel pandemic, and that people over the age of 50 might were less susceptible to infection.</p>
<p><bold>Objectives </bold>
In a mouse challenge study with the 2009 pandemic H1N1 virus, we evaluated protective immune responses elicited by prior infection with human and swine influenza A viruses.</p>
<p><bold>Results </bold>
Mice infected with A/Mexico/4108/2009 (Mex09) showed significant weight loss and 40% mortality. Prior infection with a 1976 classical swine H1N1 virus resulted in complete protection from Mex09 challenge. Prior infection with either a 2009 or a 1940 seasonal H1N1 influenza virus provided partial protection and a >100‐fold reduction in viral lung titers at day 4 post‐infection.</p>
<p><bold>Conclusions </bold>
These findings indicate that in experimental animals recently induced immunity to 1918‐derived H1N1 seasonal influenza viruses, and to a 1976 swine influenza virus, afford a degree of protection against the 2009 pandemic virus. Implications of these findings are discussed in the context of accumulating data suggesting partial protection of older persons during the 2009 pandemic.</p>
</abstract>
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