Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60 (H2N2) influenza virus
Identifieur interne : 000099 ( PascalFrancis/Checkpoint ); précédent : 000098; suivant : 000100Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60 (H2N2) influenza virus
Auteurs : M. L. Herlocher [États-Unis] ; H. F. Maassab ; R. G. Webster [États-Unis]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 1993.
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Abstract
The live cold-adapted (ca) A/AA/6/60 influenza vaccine is being commercially developed for worldwide use in children and is being used as a model for other live vaccines. Although it has been proven safe and immunogenic, the molecular basis of cold adaptation has never been determined. To identify sequence changes responsible for cold adaptation, we have compared the sequence of the master ca vaccine strain to its progenitor wild-type virus, wt A/AA/6/60 E2 (wt2)
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A.</title><idno type="ISSN">0027-8424</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation</term><term>Cold</term><term>Comparative study</term><term>Gene</term><term>Influenzavirus A</term><term>Mutation</term><term>RNA</term><term>Secondary structure</term><term>Vaccine strain</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Influenzavirus A</term><term>Souche vaccinale</term><term>Adaptation</term><term>Froid</term><term>Etude comparative</term><term>Gène</term><term>Mutation</term><term>RNA</term><term>Structure secondaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The live cold-adapted (ca) A/AA/6/60 influenza vaccine is being commercially developed for worldwide use in children and is being used as a model for other live vaccines. Although it has been proven safe and immunogenic, the molecular basis of cold adaptation has never been determined. 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F." last="Maassab">H. F. Maassab</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Herlocher, M L" sort="Herlocher, M L" uniqKey="Herlocher M" first="M. L." last="Herlocher">M. L. Herlocher</name></noRegion><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R. G." last="Webster">R. G. Webster</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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