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Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60 (H2N2) influenza virus

Identifieur interne : 000099 ( PascalFrancis/Corpus ); précédent : 000098; suivant : 000100

Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60 (H2N2) influenza virus

Auteurs : M. L. Herlocher ; H. F. Maassab ; R. G. Webster

Source :

RBID : Pascal:93-0625644

Descripteurs français

English descriptors

Abstract

The live cold-adapted (ca) A/AA/6/60 influenza vaccine is being commercially developed for worldwide use in children and is being used as a model for other live vaccines. Although it has been proven safe and immunogenic, the molecular basis of cold adaptation has never been determined. To identify sequence changes responsible for cold adaptation, we have compared the sequence of the master ca vaccine strain to its progenitor wild-type virus, wt A/AA/6/60 E2 (wt2)

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0027-8424
A02 01      @0 PNASA6
A03   1    @0 Proc. Natl. Acad. Sci. U. S. A.
A05       @2 90
A06       @2 13
A08 01  1  ENG  @1 Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60 (H2N2) influenza virus
A11 01  1    @1 HERLOCHER (M. L.)
A11 02  1    @1 MAASSAB (H. F.)
A11 03  1    @1 WEBSTER (R. G.)
A14 01      @1 Saint Jude children's res. hosp., dep. virology molecular biology @2 Memphis TN 38101 @3 USA @Z 1 aut. @Z 3 aut.
A20       @1 6032-6036
A21       @1 1993
A23 01      @0 ENG
A43 01      @1 INIST @2 574 @5 354000034849960330
A44       @0 0000
A45       @0 39 ref.
A47 01  1    @0 93-0625644
A60       @1 P
A61       @0 A
A64   1    @0 Proceedings of the National Academy of Sciences of the United States of America
A66 01      @0 USA
C01 01    ENG  @0 The live cold-adapted (ca) A/AA/6/60 influenza vaccine is being commercially developed for worldwide use in children and is being used as a model for other live vaccines. Although it has been proven safe and immunogenic, the molecular basis of cold adaptation has never been determined. To identify sequence changes responsible for cold adaptation, we have compared the sequence of the master ca vaccine strain to its progenitor wild-type virus, wt A/AA/6/60 E2 (wt2)
C02 01  X    @0 002A05C09
C03 01  X  FRE  @0 Influenzavirus A @2 NW @5 01
C03 01  X  ENG  @0 Influenzavirus A @2 NW @5 01
C03 01  X  SPA  @0 Influenzavirus A @2 NW @5 01
C03 02  X  FRE  @0 Souche vaccinale @5 05
C03 02  X  ENG  @0 Vaccine strain @5 05
C03 02  X  SPA  @0 Cepa de vacuna @5 05
C03 03  X  FRE  @0 Adaptation @5 09
C03 03  X  ENG  @0 Adaptation @5 09
C03 03  X  SPA  @0 Adaptación @5 09
C03 04  X  FRE  @0 Froid @5 13
C03 04  X  ENG  @0 Cold @5 13
C03 04  X  SPA  @0 Frío @5 13
C03 05  X  FRE  @0 Etude comparative @5 17
C03 05  X  ENG  @0 Comparative study @5 17
C03 05  X  GER  @0 Vergleich @5 17
C03 05  X  SPA  @0 Estudio comparativo @5 17
C03 06  X  FRE  @0 Gène @5 21
C03 06  X  ENG  @0 Gene @5 21
C03 06  X  SPA  @0 Gen @5 21
C03 07  X  FRE  @0 Mutation @5 43
C03 07  X  ENG  @0 Mutation @5 43
C03 07  X  SPA  @0 Mutación @5 43
C03 08  X  FRE  @0 RNA @5 46
C03 08  X  ENG  @0 RNA @5 46
C03 08  X  SPA  @0 RNA @5 46
C03 09  X  FRE  @0 Structure secondaire @5 49
C03 09  X  ENG  @0 Secondary structure @5 49
C03 09  X  GER  @0 Sekundaeres Gefuege @5 49
C03 09  X  SPA  @0 Estructura secundaria @5 49
C07 01  X  FRE  @0 Influenzavirus @2 NW
C07 01  X  ENG  @0 Influenzavirus @2 NW
C07 01  X  SPA  @0 Influenzavirus @2 NW
C07 02  X  FRE  @0 Orthomyxoviridae @2 NW
C07 02  X  ENG  @0 Orthomyxoviridae @2 NW
C07 02  X  SPA  @0 Orthomyxoviridae @2 NW
C07 03  X  FRE  @0 Virus @2 NW
C07 03  X  ENG  @0 Virus @2 NW
C07 03  X  SPA  @0 Virus @2 NW
N21       @1 306

Format Inist (serveur)

NO : PASCAL 93-0625644 INIST
ET : Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60 (H2N2) influenza virus
AU : HERLOCHER (M. L.); MAASSAB (H. F.); WEBSTER (R. G.)
AF : Saint Jude children's res. hosp., dep. virology molecular biology/Memphis TN 38101/Etats-Unis (1 aut., 3 aut.)
DT : Publication en série; Niveau analytique
SO : Proceedings of the National Academy of Sciences of the United States of America; ISSN 0027-8424; Coden PNASA6; Etats-Unis; Da. 1993; Vol. 90; No. 13; Pp. 6032-6036; Bibl. 39 ref.
LA : Anglais
EA : The live cold-adapted (ca) A/AA/6/60 influenza vaccine is being commercially developed for worldwide use in children and is being used as a model for other live vaccines. Although it has been proven safe and immunogenic, the molecular basis of cold adaptation has never been determined. To identify sequence changes responsible for cold adaptation, we have compared the sequence of the master ca vaccine strain to its progenitor wild-type virus, wt A/AA/6/60 E2 (wt2)
CC : 002A05C09
FD : Influenzavirus A; Souche vaccinale; Adaptation; Froid; Etude comparative; Gène; Mutation; RNA; Structure secondaire
FG : Influenzavirus; Orthomyxoviridae; Virus
ED : Influenzavirus A; Vaccine strain; Adaptation; Cold; Comparative study; Gene; Mutation; RNA; Secondary structure
EG : Influenzavirus; Orthomyxoviridae; Virus
GD : Vergleich; Sekundaeres Gefuege
SD : Influenzavirus A; Cepa de vacuna; Adaptación; Frío; Estudio comparativo; Gen; Mutación; RNA; Estructura secundaria
LO : INIST-574.354000034849960330
ID : 93-0625644

Links to Exploration step

Pascal:93-0625644

Le document en format XML

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