Serveur d'exploration H2N2

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Origin of the pandemic 1957 H2 influenza A viruses and the persistence of its possible progenitors in the avian reservoir

Identifieur interne : 000098 ( PascalFrancis/Checkpoint ); précédent : 000097; suivant : 000099

Origin of the pandemic 1957 H2 influenza A viruses and the persistence of its possible progenitors in the avian reservoir

Auteurs : J. R. Sch Fer [États-Unis] ; Yoshihiro Kawaoka [États-Unis] ; W. J. Bean [États-Unis] ; J. Süss ; D. Senne ; R. G. Webster [États-Unis]

Source :

RBID : Pascal:93-0578125

Descripteurs français

English descriptors

Abstract

H2N2 influenza A viruses caused the Asian pandemic of 1957 and then disappeared from the human population 10 years later. To assess the potential for similar outbreaks in the future, we determined the antigenicity of H2 hemagglutinins (HAs) from representative human and avian H2 viruses and then analyzed the nucleotide and amino acid sequences to determine their evolutionary characteristics in different hosts. The results of longitudinal virus surveillance studies were also examined to estimate the prevalence of avian H2 isolates among samples collected from wild ducks and domestic poultry. Reactivity patterns obtained with a large panel of monoclonal antibodies indicated antigenic drift in the HA of human H2 influenza viruses, beginning in 1962


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Pascal:93-0578125

Le document en format XML

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<div type="abstract" xml:lang="en">H2N2 influenza A viruses caused the Asian pandemic of 1957 and then disappeared from the human population 10 years later. To assess the potential for similar outbreaks in the future, we determined the antigenicity of H2 hemagglutinins (HAs) from representative human and avian H2 viruses and then analyzed the nucleotide and amino acid sequences to determine their evolutionary characteristics in different hosts. The results of longitudinal virus surveillance studies were also examined to estimate the prevalence of avian H2 isolates among samples collected from wild ducks and domestic poultry. Reactivity patterns obtained with a large panel of monoclonal antibodies indicated antigenic drift in the HA of human H2 influenza viruses, beginning in 1962</div>
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   |wiki=    Sante
   |area=    H2N2V1
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   |texte=   Origin of the pandemic 1957 H2 influenza A viruses and the persistence of its possible progenitors in the avian reservoir
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