Molecular constraints to interspecies transmission of viral pathogens
Identifieur interne : 000115 ( Ncbi/Curation ); précédent : 000114; suivant : 000116Molecular constraints to interspecies transmission of viral pathogens
Auteurs : Richard Webby ; Erich Hoffmann ; Robert WebsterSource :
- Nature Medicine [ 1078-8956 ] ; 2004.
Abstract
The successful replication of a viral pathogen in a host is a complex process involving many interactions. These interactions develop from the coevolution of pathogen and host and often lead to a species specificity of the virus that can make interspecies transmissions difficult. Nevertheless, viruses do sporadically cross species barriers into other host populations, including humans. In zoonotic infections, many of these interspecies transfer events are dead end, where transmission is confined only to the animal-to-human route but sometimes viruses adapt to enable spread from human to human. A pathogen must overcome many hurdles to replicate successfully in a foreign host. The viral pathogen must enter the host cell, replicate with the assistance of host factors, evade inhibitory host products, exit the first cell and move on to the next, and possibly leave the initial host and transmit to another. Each of these stages may require adaptive changes in the pathogen. Although the factors that influence each stage of the replication and transmission of most agents have not been resolved, the genomics of both hosts and pathogens are now at hand and we have begun to understand some of the molecular changes that enable some viruses to adapt to a new host.
Url:
DOI: 10.1038/nm1151
PubMed: 15577935
PubMed Central: 7095872
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000237
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000237
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000C43
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000115
Links to Exploration step
PMC:7095872Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular constraints to interspecies transmission of viral pathogens</title>
<author><name sortKey="Webby, Richard" sort="Webby, Richard" uniqKey="Webby R" first="Richard" last="Webby">Richard Webby</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hoffmann, Erich" sort="Hoffmann, Erich" uniqKey="Hoffmann E" first="Erich" last="Hoffmann">Erich Hoffmann</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Webster, Robert" sort="Webster, Robert" uniqKey="Webster R" first="Robert" last="Webster">Robert Webster</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">15577935</idno>
<idno type="pmc">7095872</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095872</idno>
<idno type="RBID">PMC:7095872</idno>
<idno type="doi">10.1038/nm1151</idno>
<date when="2004">2004</date>
<idno type="wicri:Area/Pmc/Corpus">000237</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000237</idno>
<idno type="wicri:Area/Pmc/Curation">000237</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000237</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000C43</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C43</idno>
<idno type="wicri:Area/Ncbi/Merge">000115</idno>
<idno type="wicri:Area/Ncbi/Curation">000115</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular constraints to interspecies transmission of viral pathogens</title>
<author><name sortKey="Webby, Richard" sort="Webby, Richard" uniqKey="Webby R" first="Richard" last="Webby">Richard Webby</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hoffmann, Erich" sort="Hoffmann, Erich" uniqKey="Hoffmann E" first="Erich" last="Hoffmann">Erich Hoffmann</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Webster, Robert" sort="Webster, Robert" uniqKey="Webster R" first="Robert" last="Webster">Robert Webster</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature Medicine</title>
<idno type="ISSN">1078-8956</idno>
<idno type="eISSN">1546-170X</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="Par1">The successful replication of a viral pathogen in a host is a complex process involving many interactions. These interactions develop from the coevolution of pathogen and host and often lead to a species specificity of the virus that can make interspecies transmissions difficult. Nevertheless, viruses do sporadically cross species barriers into other host populations, including humans. In zoonotic infections, many of these interspecies transfer events are dead end, where transmission is confined only to the animal-to-human route but sometimes viruses adapt to enable spread from human to human. A pathogen must overcome many hurdles to replicate successfully in a foreign host. The viral pathogen must enter the host cell, replicate with the assistance of host factors, evade inhibitory host products, exit the first cell and move on to the next, and possibly leave the initial host and transmit to another. Each of these stages may require adaptive changes in the pathogen. Although the factors that influence each stage of the replication and transmission of most agents have not been resolved, the genomics of both hosts and pathogens are now at hand and we have begun to understand some of the molecular changes that enable some viruses to adapt to a new host.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Smolinski, M" uniqKey="Smolinski M">M Smolinski</name>
</author>
<author><name sortKey="Hamburg, M" uniqKey="Hamburg M">M Hamburg</name>
</author>
<author><name sortKey="Lederberg, J" uniqKey="Lederberg J">J Lederberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Ks" uniqKey="Li K">KS Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nie, Y" uniqKey="Nie Y">Y Nie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meyer, Bj" uniqKey="Meyer B">BJ Meyer</name>
</author>
<author><name sortKey="De La Torre, Jc" uniqKey="De La Torre J">JC de la Torre</name>
</author>
<author><name sortKey="Southern, Pj" uniqKey="Southern P">PJ Southern</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name>
</author>
<author><name sortKey="Zelus, Bd" uniqKey="Zelus B">BD Zelus</name>
</author>
<author><name sortKey="Schickli, Jh" uniqKey="Schickli J">JH Schickli</name>
</author>
<author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thackray, Lb" uniqKey="Thackray L">LB Thackray</name>
</author>
<author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baranowski, E" uniqKey="Baranowski E">E Baranowski</name>
</author>
<author><name sortKey="Ruiz Jarabo, Cm" uniqKey="Ruiz Jarabo C">CM Ruiz-Jarabo</name>
</author>
<author><name sortKey="Domingo, E" uniqKey="Domingo E">E Domingo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Couceiro, Jn" uniqKey="Couceiro J">JN Couceiro</name>
</author>
<author><name sortKey="Paulson, Jc" uniqKey="Paulson J">JC Paulson</name>
</author>
<author><name sortKey="Baum, Lg" uniqKey="Baum L">LG Baum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ito, T" uniqKey="Ito T">T Ito</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beare, As" uniqKey="Beare A">AS Beare</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hinshaw, Vs" uniqKey="Hinshaw V">VS Hinshaw</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
<author><name sortKey="Easterday, Bc" uniqKey="Easterday B">BC Easterday</name>
</author>
<author><name sortKey="Bean, Wj" uniqKey="Bean W">WJ Bean</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hinshaw, Vs" uniqKey="Hinshaw V">VS Hinshaw</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
<author><name sortKey="Naeve, Cw" uniqKey="Naeve C">CW Naeve</name>
</author>
<author><name sortKey="Murphy, Br" uniqKey="Murphy B">BR Murphy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murphy, Br" uniqKey="Murphy B">BR Murphy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matrosovich, M" uniqKey="Matrosovich M">M Matrosovich</name>
</author>
<author><name sortKey="Zhou, N" uniqKey="Zhou N">N Zhou</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
<author><name sortKey="Webster, R" uniqKey="Webster R">R Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matrosovich, Mn" uniqKey="Matrosovich M">MN Matrosovich</name>
</author>
<author><name sortKey="Krauss, S" uniqKey="Krauss S">S Krauss</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matrosovich, Mn" uniqKey="Matrosovich M">MN Matrosovich</name>
</author>
<author><name sortKey="Matrosovich, Ty" uniqKey="Matrosovich T">TY Matrosovich</name>
</author>
<author><name sortKey="Gray, T" uniqKey="Gray T">T Gray</name>
</author>
<author><name sortKey="Roberts, Na" uniqKey="Roberts N">NA Roberts</name>
</author>
<author><name sortKey="Klenk, Hd" uniqKey="Klenk H">HD Klenk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blight, Kj" uniqKey="Blight K">KJ Blight</name>
</author>
<author><name sortKey="Kolykhalov, Aa" uniqKey="Kolykhalov A">AA Kolykhalov</name>
</author>
<author><name sortKey="Rice, Cm" uniqKey="Rice C">CM Rice</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Isaacs, A" uniqKey="Isaacs A">A Isaacs</name>
</author>
<author><name sortKey="Lindenmann, J" uniqKey="Lindenmann J">J Lindenmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Isaacs, A" uniqKey="Isaacs A">A Isaacs</name>
</author>
<author><name sortKey="Burke, Dc" uniqKey="Burke D">DC Burke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
<author><name sortKey="He, Y" uniqKey="He Y">Y He</name>
</author>
<author><name sortKey="Gale, M" uniqKey="Gale M">M Gale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krug, Rm" uniqKey="Krug R">RM Krug</name>
</author>
<author><name sortKey="Yuan, W" uniqKey="Yuan W">W Yuan</name>
</author>
<author><name sortKey="Noah, Dl" uniqKey="Noah D">DL Noah</name>
</author>
<author><name sortKey="Latham, Ag" uniqKey="Latham A">AG Latham</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, Ms" uniqKey="Park M">MS Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rodriguez, Jj" uniqKey="Rodriguez J">JJ Rodriguez</name>
</author>
<author><name sortKey="Parisien, Jp" uniqKey="Parisien J">JP Parisien</name>
</author>
<author><name sortKey="Horvath, Cm" uniqKey="Horvath C">CM Horvath</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rodriguez, Jj" uniqKey="Rodriguez J">JJ Rodriguez</name>
</author>
<author><name sortKey="Wang, Lf" uniqKey="Wang L">LF Wang</name>
</author>
<author><name sortKey="Horvath, Cm" uniqKey="Horvath C">CM Horvath</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harcourt, Bh" uniqKey="Harcourt B">BH Harcourt</name>
</author>
<author><name sortKey="Sanchez, A" uniqKey="Sanchez A">A Sanchez</name>
</author>
<author><name sortKey="Offermann, Mk" uniqKey="Offermann M">MK Offermann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Enomoto, N" uniqKey="Enomoto N">N Enomoto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A Garcia-Sastre</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name>
</author>
<author><name sortKey="Wambach, M" uniqKey="Wambach M">M Wambach</name>
</author>
<author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
<author><name sortKey="Krug, Rm" uniqKey="Krug R">RM Krug</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Krug, Rm" uniqKey="Krug R">RM Krug</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nemeroff, Me" uniqKey="Nemeroff M">ME Nemeroff</name>
</author>
<author><name sortKey="Barabino, Sm" uniqKey="Barabino S">SM Barabino</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Keller, W" uniqKey="Keller W">W Keller</name>
</author>
<author><name sortKey="Krug, Rm" uniqKey="Krug R">RM Krug</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parisien, Jp" uniqKey="Parisien J">JP Parisien</name>
</author>
<author><name sortKey="Lau, Jf" uniqKey="Lau J">JF Lau</name>
</author>
<author><name sortKey="Horvath, Cm" uniqKey="Horvath C">CM Horvath</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
<author><name sortKey="Krauss, S" uniqKey="Krauss S">S Krauss</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scholtissek, C" uniqKey="Scholtissek C">C Scholtissek</name>
</author>
<author><name sortKey="Rohde, W" uniqKey="Rohde W">W Rohde</name>
</author>
<author><name sortKey="Von, Hv" uniqKey="Von H">HV von</name>
</author>
<author><name sortKey="Rott, R" uniqKey="Rott R">R Rott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fujii, Y" uniqKey="Fujii Y">Y Fujii</name>
</author>
<author><name sortKey="Goto, H" uniqKey="Goto H">H Goto</name>
</author>
<author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name>
</author>
<author><name sortKey="Yoshida, T" uniqKey="Yoshida T">T Yoshida</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sevilla, N" uniqKey="Sevilla N">N Sevilla</name>
</author>
<author><name sortKey="Domingo, E" uniqKey="Domingo E">E Domingo</name>
</author>
<author><name sortKey="De La Torre, Jc" uniqKey="De La Torre J">JC de la Torre</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lai, Mm" uniqKey="Lai M">MM Lai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nagy, Pd" uniqKey="Nagy P">PD Nagy</name>
</author>
<author><name sortKey="Simon, Ae" uniqKey="Simon A">AE Simon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Suarez, Dl" uniqKey="Suarez D">DL Suarez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hahn, Bh" uniqKey="Hahn B">BH Hahn</name>
</author>
<author><name sortKey="Shaw, Gm" uniqKey="Shaw G">GM Shaw</name>
</author>
<author><name sortKey="De Cock, Km" uniqKey="De Cock K">KM De Cock</name>
</author>
<author><name sortKey="Sharp, Pm" uniqKey="Sharp P">PM Sharp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lemey, P" uniqKey="Lemey P">P Lemey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bieniasz, Pd" uniqKey="Bieniasz P">PD Bieniasz</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Kobasa, D" uniqKey="Kobasa D">D Kobasa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000115 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000115 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:7095872 |texte= Molecular constraints to interspecies transmission of viral pathogens }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:15577935" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a H2N2V1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |