Preparation and characterization of live recombinant influenza vaccine.
Identifieur interne : 001357 ( Ncbi/Checkpoint ); précédent : 001356; suivant : 001358Preparation and characterization of live recombinant influenza vaccine.
Auteurs : V M Stealey ; D. Mccahon ; D S FreestoneSource :
- Developments in biological standardization [ 0301-5149 ] ; 1976.
Descripteurs français
- KwdFr :
- Administration par voie nasale, Anticorps antiviraux (analyse), Humains, Nez (microbiologie), Orthomyxoviridae (immunologie), Recombinaison génétique, Sang (microbiologie), Tests d'inhibition de l'hémagglutination, Vaccins antigrippaux (administration et posologie), Virus de la grippe A (immunologie), Virus de la grippe A (isolement et purification).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- analyse : Anticorps antiviraux.
- immunologie : Orthomyxoviridae, Virus de la grippe A.
- isolement et purification : Virus de la grippe A.
- microbiologie : Nez, Sang.
- Administration par voie nasale, Humains, Recombinaison génétique, Tests d'inhibition de l'hémagglutination.
English descriptors
- KwdEn :
- Administration, Intranasal, Antibodies, Viral (analysis), Blood (microbiology), Hemagglutination Inhibition Tests, Humans, Influenza A virus (immunology), Influenza A virus (isolation & purification), Influenza Vaccines (administration & dosage), Nose (microbiology), Orthomyxoviridae (immunology), Recombination, Genetic.
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , analysis : Antibodies, Viral.
- immunology : Influenza A virus, Orthomyxoviridae.
- isolation & purification : Influenza A virus.
- microbiology : Blood, Nose.
- Administration, Intranasal, Hemagglutination Inhibition Tests, Humans, Recombination, Genetic.
Abstract
Strain WRL 105 was prepared by recombination between the A/Finland/4/74 (H3N2) and attenuated A/Okuda/57 (H2N2) strains by a method previously described. A single intranasal dose of WRL 105 strain live attenuated influenza vaccine was administered to volunteers at three dose levels and homologous serum antibody titres and virus excretion were monitored. Doses greater than 10(6.3)EID50 gave 4-fold or greater increases in antibody titre in 80% of seronegative volunteers.
PubMed: 955267
Affiliations:
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pubmed:955267Le document en format XML
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<author><name sortKey="Freestone, D S" sort="Freestone, D S" uniqKey="Freestone D" first="D S" last="Freestone">D S Freestone</name>
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<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza A virus (isolation & purification)</term>
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<term>Recombinaison génétique</term>
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<term>Virus de la grippe A (isolement et purification)</term>
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<term>Virus de la grippe A</term>
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<term>Sang</term>
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<term>Hemagglutination Inhibition Tests</term>
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<front><div type="abstract" xml:lang="en">Strain WRL 105 was prepared by recombination between the A/Finland/4/74 (H3N2) and attenuated A/Okuda/57 (H2N2) strains by a method previously described. A single intranasal dose of WRL 105 strain live attenuated influenza vaccine was administered to volunteers at three dose levels and homologous serum antibody titres and virus excretion were monitored. Doses greater than 10(6.3)EID50 gave 4-fold or greater increases in antibody titre in 80% of seronegative volunteers.</div>
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<name sortKey="Mccahon, D" sort="Mccahon, D" uniqKey="Mccahon D" first="D" last="Mccahon">D. Mccahon</name>
<name sortKey="Stealey, V M" sort="Stealey, V M" uniqKey="Stealey V" first="V M" last="Stealey">V M Stealey</name>
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