Preparation and characterization of live recombinant influenza vaccine.
Identifieur interne : 000646 ( PubMed/Corpus ); précédent : 000645; suivant : 000647Preparation and characterization of live recombinant influenza vaccine.
Auteurs : V M Stealey ; D. Mccahon ; D S FreestoneSource :
- Developments in biological standardization [ 0301-5149 ] ; 1976.
English descriptors
- KwdEn :
- Administration, Intranasal, Antibodies, Viral (analysis), Blood (microbiology), Hemagglutination Inhibition Tests, Humans, Influenza A virus (immunology), Influenza A virus (isolation & purification), Influenza Vaccines (administration & dosage), Nose (microbiology), Orthomyxoviridae (immunology), Recombination, Genetic.
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , analysis : Antibodies, Viral.
- immunology : Influenza A virus, Orthomyxoviridae.
- isolation & purification : Influenza A virus.
- microbiology : Blood, Nose.
- Administration, Intranasal, Hemagglutination Inhibition Tests, Humans, Recombination, Genetic.
Abstract
Strain WRL 105 was prepared by recombination between the A/Finland/4/74 (H3N2) and attenuated A/Okuda/57 (H2N2) strains by a method previously described. A single intranasal dose of WRL 105 strain live attenuated influenza vaccine was administered to volunteers at three dose levels and homologous serum antibody titres and virus excretion were monitored. Doses greater than 10(6.3)EID50 gave 4-fold or greater increases in antibody titre in 80% of seronegative volunteers.
PubMed: 955267
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pubmed:955267Le document en format XML
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Mccahon</name></author><author><name sortKey="Freestone, D S" sort="Freestone, D S" uniqKey="Freestone D" first="D S" last="Freestone">D S Freestone</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1976">1976</date><idno type="RBID">pubmed:955267</idno><idno type="pmid">955267</idno><idno type="wicri:Area/PubMed/Corpus">000646</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000646</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Preparation and characterization of live recombinant influenza vaccine.</title><author><name sortKey="Stealey, V M" sort="Stealey, V M" uniqKey="Stealey V" first="V M" last="Stealey">V M Stealey</name></author><author><name sortKey="Mccahon, D" sort="Mccahon, D" uniqKey="Mccahon D" first="D" last="Mccahon">D. Mccahon</name></author><author><name sortKey="Freestone, D S" sort="Freestone, D S" uniqKey="Freestone D" first="D S" last="Freestone">D S Freestone</name></author></analytic><series><title level="j">Developments in biological standardization</title><idno type="ISSN">0301-5149</idno><imprint><date when="1976" type="published">1976</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Intranasal</term><term>Antibodies, Viral (analysis)</term><term>Blood (microbiology)</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Influenza A virus (immunology)</term><term>Influenza A virus (isolation & purification)</term><term>Influenza Vaccines (administration & dosage)</term><term>Nose (microbiology)</term><term>Orthomyxoviridae (immunology)</term><term>Recombination, Genetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Blood</term><term>Nose</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Recombination, Genetic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Strain WRL 105 was prepared by recombination between the A/Finland/4/74 (H3N2) and attenuated A/Okuda/57 (H2N2) strains by a method previously described. A single intranasal dose of WRL 105 strain live attenuated influenza vaccine was administered to volunteers at three dose levels and homologous serum antibody titres and virus excretion were monitored. Doses greater than 10(6.3)EID50 gave 4-fold or greater increases in antibody titre in 80% of seronegative volunteers.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">955267</PMID><DateCompleted><Year>1976</Year><Month>11</Month><Day>01</Day></DateCompleted><DateRevised><Year>2005</Year><Month>11</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0301-5149</ISSN><JournalIssue CitedMedium="Print"><Volume>33</Volume><PubDate><Year>1976</Year></PubDate></JournalIssue><Title>Developments in biological standardization</Title><ISOAbbreviation>Dev. Biol. Stand.</ISOAbbreviation></Journal><ArticleTitle>Preparation and characterization of live recombinant influenza vaccine.</ArticleTitle><Pagination><MedlinePgn>191-6</MedlinePgn></Pagination><Abstract><AbstractText>Strain WRL 105 was prepared by recombination between the A/Finland/4/74 (H3N2) and attenuated A/Okuda/57 (H2N2) strains by a method previously described. A single intranasal dose of WRL 105 strain live attenuated influenza vaccine was administered to volunteers at three dose levels and homologous serum antibody titres and virus excretion were monitored. Doses greater than 10(6.3)EID50 gave 4-fold or greater increases in antibody titre in 80% of seronegative volunteers.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Stealey</LastName><ForeName>V M</ForeName><Initials>VM</Initials></Author><Author ValidYN="Y"><LastName>McCahon</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Freestone</LastName><ForeName>D S</ForeName><Initials>DS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Dev Biol Stand</MedlineTA><NlmUniqueID>0427140</NlmUniqueID><ISSNLinking>0301-5149</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000281" MajorTopicYN="N">Administration, Intranasal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001769" MajorTopicYN="N">Blood</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006385" MajorTopicYN="N">Hemagglutination Inhibition Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="Y">Influenza Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009666" MajorTopicYN="N">Nose</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009975" MajorTopicYN="N">Orthomyxoviridae</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011995" MajorTopicYN="N">Recombination, Genetic</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1976</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1976</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1976</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">955267</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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