Preparation and characterization of live recombinant influenza vaccine.
Identifieur interne : 000646 ( PubMed/Curation ); précédent : 000645; suivant : 000647Preparation and characterization of live recombinant influenza vaccine.
Auteurs : V M Stealey ; D. Mccahon ; D S FreestoneSource :
- Developments in biological standardization [ 0301-5149 ] ; 1976.
Descripteurs français
- KwdFr :
- Administration par voie nasale, Anticorps antiviraux (analyse), Humains, Nez (microbiologie), Orthomyxoviridae (immunologie), Recombinaison génétique, Sang (microbiologie), Tests d'inhibition de l'hémagglutination, Vaccins antigrippaux (administration et posologie), Virus de la grippe A (immunologie), Virus de la grippe A (isolement et purification).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- analyse : Anticorps antiviraux.
- immunologie : Orthomyxoviridae, Virus de la grippe A.
- isolement et purification : Virus de la grippe A.
- microbiologie : Nez, Sang.
- Administration par voie nasale, Humains, Recombinaison génétique, Tests d'inhibition de l'hémagglutination.
English descriptors
- KwdEn :
- Administration, Intranasal, Antibodies, Viral (analysis), Blood (microbiology), Hemagglutination Inhibition Tests, Humans, Influenza A virus (immunology), Influenza A virus (isolation & purification), Influenza Vaccines (administration & dosage), Nose (microbiology), Orthomyxoviridae (immunology), Recombination, Genetic.
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , analysis : Antibodies, Viral.
- immunology : Influenza A virus, Orthomyxoviridae.
- isolation & purification : Influenza A virus.
- microbiology : Blood, Nose.
- Administration, Intranasal, Hemagglutination Inhibition Tests, Humans, Recombination, Genetic.
Abstract
Strain WRL 105 was prepared by recombination between the A/Finland/4/74 (H3N2) and attenuated A/Okuda/57 (H2N2) strains by a method previously described. A single intranasal dose of WRL 105 strain live attenuated influenza vaccine was administered to volunteers at three dose levels and homologous serum antibody titres and virus excretion were monitored. Doses greater than 10(6.3)EID50 gave 4-fold or greater increases in antibody titre in 80% of seronegative volunteers.
PubMed: 955267
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pubmed:955267Le document en format XML
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<author><name sortKey="Freestone, D S" sort="Freestone, D S" uniqKey="Freestone D" first="D S" last="Freestone">D S Freestone</name>
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<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza A virus (isolation & purification)</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Nose (microbiology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie nasale</term>
<term>Anticorps antiviraux (analyse)</term>
<term>Humains</term>
<term>Nez (microbiologie)</term>
<term>Orthomyxoviridae (immunologie)</term>
<term>Recombinaison génétique</term>
<term>Sang (microbiologie)</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Vaccins antigrippaux (administration et posologie)</term>
<term>Virus de la grippe A (immunologie)</term>
<term>Virus de la grippe A (isolement et purification)</term>
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<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term>
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<term>Orthomyxoviridae</term>
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<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A virus</term>
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<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Nez</term>
<term>Sang</term>
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<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Blood</term>
<term>Nose</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Recombination, Genetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Administration par voie nasale</term>
<term>Humains</term>
<term>Recombinaison génétique</term>
<term>Tests d'inhibition de l'hémagglutination</term>
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<front><div type="abstract" xml:lang="en">Strain WRL 105 was prepared by recombination between the A/Finland/4/74 (H3N2) and attenuated A/Okuda/57 (H2N2) strains by a method previously described. A single intranasal dose of WRL 105 strain live attenuated influenza vaccine was administered to volunteers at three dose levels and homologous serum antibody titres and virus excretion were monitored. Doses greater than 10(6.3)EID50 gave 4-fold or greater increases in antibody titre in 80% of seronegative volunteers.</div>
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<Title>Developments in biological standardization</Title>
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<ArticleTitle>Preparation and characterization of live recombinant influenza vaccine.</ArticleTitle>
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<Abstract><AbstractText>Strain WRL 105 was prepared by recombination between the A/Finland/4/74 (H3N2) and attenuated A/Okuda/57 (H2N2) strains by a method previously described. A single intranasal dose of WRL 105 strain live attenuated influenza vaccine was administered to volunteers at three dose levels and homologous serum antibody titres and virus excretion were monitored. Doses greater than 10(6.3)EID50 gave 4-fold or greater increases in antibody titre in 80% of seronegative volunteers.</AbstractText>
</Abstract>
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