Characterization of Reverse Genetics-Derived Cold-Adapted Master Donor Virus A/Leningrad/134/17/57 (H2N2) and Reassortants with H5N1 Surface Genes in a Mouse Model
Identifieur interne : 000A21 ( Ncbi/Checkpoint ); précédent : 000A20; suivant : 000A22Characterization of Reverse Genetics-Derived Cold-Adapted Master Donor Virus A/Leningrad/134/17/57 (H2N2) and Reassortants with H5N1 Surface Genes in a Mouse Model
Auteurs : Irina Isakova-Sivak [États-Unis, Russie] ; Li-Mei Chen [États-Unis] ; Melissa Bourgeois [États-Unis] ; Yumiko Matsuoka [États-Unis] ; J. Theo M. Voeten [Pays-Bas] ; Jacco G. M. Heldens [Pays-Bas] ; Han Van Den Bosch [Pays-Bas] ; Alexander Klimov [États-Unis] ; Larisa Rudenko [Russie] ; Nancy J. Cox [États-Unis] ; Ruben O. Donis [États-Unis]Source :
- Clinical and Vaccine Immunology : CVI [ 1556-6811 ] ; 2014.
Descripteurs français
- KwdFr :
- Analyse de survie, Animaux, Anticorps antiviraux (sang), Femelle, Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (immunologie), Génétique inverse, Immunoglobuline A (sang), Infections à Orthomyxoviridae (), Modèles animaux de maladie humaine, Protéines virales (génétique), Protéines virales (immunologie), Sialidase (génétique), Sialidase (immunologie), Souris de lignée BALB C, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (génétique), Sous-type H5N1 du virus de la grippe A (immunologie), Structures anatomiques de l'animal (virologie), Vaccination (), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins atténués (administration et posologie), Vaccins atténués (génétique), Vaccins atténués (immunologie), Vaccins synthétiques (administration et posologie), Vaccins synthétiques (génétique), Vaccins synthétiques (immunologie), Virulence, Virus recombinants (génétique), Virus recombinants (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins atténués, Vaccins synthétiques.
- génétique : Glycoprotéine hémagglutinine du virus influenza, Protéines virales, Sialidase, Sous-type H2N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués, Vaccins synthétiques, Virus recombinants.
- immunologie : Glycoprotéine hémagglutinine du virus influenza, Protéines virales, Sialidase, Sous-type H2N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués, Vaccins synthétiques, Virus recombinants.
- sang : Anticorps antiviraux, Immunoglobuline A.
- virologie : Structures anatomiques de l'animal.
- Analyse de survie, Animaux, Femelle, Génétique inverse, Infections à Orthomyxoviridae, Modèles animaux de maladie humaine, Souris de lignée BALB C, Vaccination, Virulence.
English descriptors
- KwdEn :
- Animal Structures (virology), Animals, Antibodies, Viral (blood), Disease Models, Animal, Female, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Immunoglobulin A (blood), Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H5N1 Subtype (genetics), Influenza A Virus, H5N1 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Mice, Inbred BALB C, Neuraminidase (genetics), Neuraminidase (immunology), Orthomyxoviridae Infections (prevention & control), Reassortant Viruses (genetics), Reassortant Viruses (immunology), Reverse Genetics, Survival Analysis, Vaccination (methods), Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (genetics), Vaccines, Attenuated (immunology), Vaccines, Synthetic (administration & dosage), Vaccines, Synthetic (genetics), Vaccines, Synthetic (immunology), Viral Proteins (genetics), Viral Proteins (immunology), Virulence.
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Attenuated, Vaccines, Synthetic.
- chemical , blood : Antibodies, Viral, Immunoglobulin A.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Neuraminidase, Vaccines, Attenuated, Vaccines, Synthetic, Viral Proteins.
- chemical , immunology : Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Neuraminidase, Vaccines, Attenuated, Vaccines, Synthetic, Viral Proteins.
- genetics : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Reassortant Viruses.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Reassortant Viruses.
- methods : Vaccination.
- prevention & control : Orthomyxoviridae Infections.
- virology : Animal Structures.
- Animals, Disease Models, Animal, Female, Mice, Inbred BALB C, Reverse Genetics, Survival Analysis, Virulence.
Abstract
Live attenuated influenza vaccines (LAIV) offer significant advantages over subunit or split inactivated vaccines to mitigate an eventual influenza pandemic, including simpler manufacturing processes and more cross-protective immune responses. Using an established reverse genetics (rg) system for wild-type (
Url:
DOI: 10.1128/CVI.00819-13
PubMed: 24648485
PubMed Central: 4018889
Affiliations:
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PMC:4018889Le document en format XML
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<term>Vaccination ()</term>
<term>Vaccins antigrippaux (administration et posologie)</term>
<term>Vaccins antigrippaux (génétique)</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Vaccins atténués (administration et posologie)</term>
<term>Vaccins atténués (génétique)</term>
<term>Vaccins atténués (immunologie)</term>
<term>Vaccins synthétiques (administration et posologie)</term>
<term>Vaccins synthétiques (génétique)</term>
<term>Vaccins synthétiques (immunologie)</term>
<term>Virulence</term>
<term>Virus recombinants (génétique)</term>
<term>Virus recombinants (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term>
<term>Vaccines, Attenuated</term>
<term>Vaccines, Synthetic</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
<term>Immunoglobulin A</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Influenza Vaccines</term>
<term>Neuraminidase</term>
<term>Vaccines, Attenuated</term>
<term>Vaccines, Synthetic</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Influenza Vaccines</term>
<term>Neuraminidase</term>
<term>Vaccines, Attenuated</term>
<term>Vaccines, Synthetic</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term>
<term>Vaccins atténués</term>
<term>Vaccins synthétiques</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H5N1 Subtype</term>
<term>Reassortant Viruses</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Protéines virales</term>
<term>Sialidase</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins atténués</term>
<term>Vaccins synthétiques</term>
<term>Virus recombinants</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Protéines virales</term>
<term>Sialidase</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins atténués</term>
<term>Vaccins synthétiques</term>
<term>Virus recombinants</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H5N1 Subtype</term>
<term>Reassortant Viruses</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Vaccination</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Immunoglobuline A</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Structures anatomiques de l'animal</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Animal Structures</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Mice, Inbred BALB C</term>
<term>Reverse Genetics</term>
<term>Survival Analysis</term>
<term>Virulence</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de survie</term>
<term>Animaux</term>
<term>Femelle</term>
<term>Génétique inverse</term>
<term>Infections à Orthomyxoviridae</term>
<term>Modèles animaux de maladie humaine</term>
<term>Souris de lignée BALB C</term>
<term>Vaccination</term>
<term>Virulence</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Live attenuated influenza vaccines (LAIV) offer significant advantages over subunit or split inactivated vaccines to mitigate an eventual influenza pandemic, including simpler manufacturing processes and more cross-protective immune responses. Using an established reverse genetics (rg) system for wild-type (<italic>wt</italic>
) A/Leningrad/134/1957 and cold-adapted (<italic>ca</italic>
) A/Leningrad/134/17/1957 (Len17) master donor virus (MDV), we produced and characterized three rg H5N1 reassortant viruses carrying modified HA and intact NA genes from either A/Vietnam/1203/2004 (H5N1, VN1203, clade 1) or A/Egypt/321/2007 (H5N1, EG321, clade 2) virus. A mouse model of infection was used to determine the infectivity and tissue tropism of the parental <italic>wt</italic>
viruses compared to the <italic>ca</italic>
master donor viruses as well as the H5N1 reassortants. All <italic>ca</italic>
viruses showed reduced replication in lungs and enhanced replication in nasal epithelium. In addition, the H5N1 HA and NA enhanced replication in lungs unless it was restricted by the internal genes of the <italic>ca</italic>
MDV. Mice inoculated twice 4 weeks apart with the H5N1 reassortant LAIV candidate viruses developed serum hemagglutination inhibition HI and IgA antibody titers to the homologous and heterologous viruses consistent with protective immunity. These animals remained healthy after challenge inoculation with a lethal dose with homologous or heterologous <italic>wt</italic>
H5N1 highly pathogenic avian influenza (HPAI) viruses. The profiles of viral replication in respiratory tissues and the immunogenicity and protective efficacy characteristics of the two <italic>ca</italic>
H5N1 candidate LAIV viruses warrant further development into a vaccine for human use.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Pays-Bas</li>
<li>Russie</li>
<li>États-Unis</li>
</country>
<region><li>Géorgie (États-Unis)</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Isakova Sivak, Irina" sort="Isakova Sivak, Irina" uniqKey="Isakova Sivak I" first="Irina" last="Isakova-Sivak">Irina Isakova-Sivak</name>
</region>
<name sortKey="Bourgeois, Melissa" sort="Bourgeois, Melissa" uniqKey="Bourgeois M" first="Melissa" last="Bourgeois">Melissa Bourgeois</name>
<name sortKey="Chen, Li Mei" sort="Chen, Li Mei" uniqKey="Chen L" first="Li-Mei" last="Chen">Li-Mei Chen</name>
<name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J." last="Cox">Nancy J. Cox</name>
<name sortKey="Donis, Ruben O" sort="Donis, Ruben O" uniqKey="Donis R" first="Ruben O." last="Donis">Ruben O. Donis</name>
<name sortKey="Klimov, Alexander" sort="Klimov, Alexander" uniqKey="Klimov A" first="Alexander" last="Klimov">Alexander Klimov</name>
<name sortKey="Matsuoka, Yumiko" sort="Matsuoka, Yumiko" uniqKey="Matsuoka Y" first="Yumiko" last="Matsuoka">Yumiko Matsuoka</name>
</country>
<country name="Russie"><noRegion><name sortKey="Isakova Sivak, Irina" sort="Isakova Sivak, Irina" uniqKey="Isakova Sivak I" first="Irina" last="Isakova-Sivak">Irina Isakova-Sivak</name>
</noRegion>
<name sortKey="Rudenko, Larisa" sort="Rudenko, Larisa" uniqKey="Rudenko L" first="Larisa" last="Rudenko">Larisa Rudenko</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Voeten, J Theo M" sort="Voeten, J Theo M" uniqKey="Voeten J" first="J. Theo M." last="Voeten">J. Theo M. Voeten</name>
</noRegion>
<name sortKey="Heldens, Jacco G M" sort="Heldens, Jacco G M" uniqKey="Heldens J" first="Jacco G. M." last="Heldens">Jacco G. M. Heldens</name>
<name sortKey="Van Den Bosch, Han" sort="Van Den Bosch, Han" uniqKey="Van Den Bosch H" first="Han" last="Van Den Bosch">Han Van Den Bosch</name>
</country>
</tree>
</affiliations>
</record>
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