Serveur d'exploration H2N2

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Characterization of reverse genetics-derived cold-adapted master donor virus A/Leningrad/134/17/57 (H2N2) and reassortants with H5N1 surface genes in a mouse model.

Identifieur interne : 000103 ( PubMed/Curation ); précédent : 000102; suivant : 000104

Characterization of reverse genetics-derived cold-adapted master donor virus A/Leningrad/134/17/57 (H2N2) and reassortants with H5N1 surface genes in a mouse model.

Auteurs : Irina Isakova-Sivak [États-Unis] ; Li-Mei Chen ; Melissa Bourgeois ; Yumiko Matsuoka ; J Theo M. Voeten ; Jacco G M. Heldens ; Han Van Den Bosch ; Alexander Klimov ; Larisa Rudenko ; Nancy J. Cox ; Ruben O. Donis

Source :

RBID : pubmed:24648485

Descripteurs français

English descriptors

Abstract

Live attenuated influenza vaccines (LAIV) offer significant advantages over subunit or split inactivated vaccines to mitigate an eventual influenza pandemic, including simpler manufacturing processes and more cross-protective immune responses. Using an established reverse genetics (rg) system for wild-type (wt) A/Leningrad/134/1957 and cold-adapted (ca) A/Leningrad/134/17/1957 (Len17) master donor virus (MDV), we produced and characterized three rg H5N1 reassortant viruses carrying modified HA and intact NA genes from either A/Vietnam/1203/2004 (H5N1, VN1203, clade 1) or A/Egypt/321/2007 (H5N1, EG321, clade 2) virus. A mouse model of infection was used to determine the infectivity and tissue tropism of the parental wt viruses compared to the ca master donor viruses as well as the H5N1 reassortants. All ca viruses showed reduced replication in lungs and enhanced replication in nasal epithelium. In addition, the H5N1 HA and NA enhanced replication in lungs unless it was restricted by the internal genes of the ca MDV. Mice inoculated twice 4 weeks apart with the H5N1 reassortant LAIV candidate viruses developed serum hemagglutination inhibition HI and IgA antibody titers to the homologous and heterologous viruses consistent with protective immunity. These animals remained healthy after challenge inoculation with a lethal dose with homologous or heterologous wt H5N1 highly pathogenic avian influenza (HPAI) viruses. The profiles of viral replication in respiratory tissues and the immunogenicity and protective efficacy characteristics of the two ca H5N1 candidate LAIV viruses warrant further development into a vaccine for human use.

DOI: 10.1128/CVI.00819-13
PubMed: 24648485

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<div type="abstract" xml:lang="en">Live attenuated influenza vaccines (LAIV) offer significant advantages over subunit or split inactivated vaccines to mitigate an eventual influenza pandemic, including simpler manufacturing processes and more cross-protective immune responses. Using an established reverse genetics (rg) system for wild-type (wt) A/Leningrad/134/1957 and cold-adapted (ca) A/Leningrad/134/17/1957 (Len17) master donor virus (MDV), we produced and characterized three rg H5N1 reassortant viruses carrying modified HA and intact NA genes from either A/Vietnam/1203/2004 (H5N1, VN1203, clade 1) or A/Egypt/321/2007 (H5N1, EG321, clade 2) virus. A mouse model of infection was used to determine the infectivity and tissue tropism of the parental wt viruses compared to the ca master donor viruses as well as the H5N1 reassortants. All ca viruses showed reduced replication in lungs and enhanced replication in nasal epithelium. In addition, the H5N1 HA and NA enhanced replication in lungs unless it was restricted by the internal genes of the ca MDV. Mice inoculated twice 4 weeks apart with the H5N1 reassortant LAIV candidate viruses developed serum hemagglutination inhibition HI and IgA antibody titers to the homologous and heterologous viruses consistent with protective immunity. These animals remained healthy after challenge inoculation with a lethal dose with homologous or heterologous wt H5N1 highly pathogenic avian influenza (HPAI) viruses. The profiles of viral replication in respiratory tissues and the immunogenicity and protective efficacy characteristics of the two ca H5N1 candidate LAIV viruses warrant further development into a vaccine for human use.</div>
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<AbstractText>Live attenuated influenza vaccines (LAIV) offer significant advantages over subunit or split inactivated vaccines to mitigate an eventual influenza pandemic, including simpler manufacturing processes and more cross-protective immune responses. Using an established reverse genetics (rg) system for wild-type (wt) A/Leningrad/134/1957 and cold-adapted (ca) A/Leningrad/134/17/1957 (Len17) master donor virus (MDV), we produced and characterized three rg H5N1 reassortant viruses carrying modified HA and intact NA genes from either A/Vietnam/1203/2004 (H5N1, VN1203, clade 1) or A/Egypt/321/2007 (H5N1, EG321, clade 2) virus. A mouse model of infection was used to determine the infectivity and tissue tropism of the parental wt viruses compared to the ca master donor viruses as well as the H5N1 reassortants. All ca viruses showed reduced replication in lungs and enhanced replication in nasal epithelium. In addition, the H5N1 HA and NA enhanced replication in lungs unless it was restricted by the internal genes of the ca MDV. Mice inoculated twice 4 weeks apart with the H5N1 reassortant LAIV candidate viruses developed serum hemagglutination inhibition HI and IgA antibody titers to the homologous and heterologous viruses consistent with protective immunity. These animals remained healthy after challenge inoculation with a lethal dose with homologous or heterologous wt H5N1 highly pathogenic avian influenza (HPAI) viruses. The profiles of viral replication in respiratory tissues and the immunogenicity and protective efficacy characteristics of the two ca H5N1 candidate LAIV viruses warrant further development into a vaccine for human use.</AbstractText>
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<ArticleId IdType="pubmed">24648485</ArticleId>
<ArticleId IdType="pii">CVI.00819-13</ArticleId>
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<ArticleId IdType="pmc">PMC4018889</ArticleId>
</ArticleIdList>
<ReferenceList>
<Reference>
<Citation>Virology. 2011 Apr 10;412(2):297-305</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21315402</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Arch Virol. 2010 Sep;155(9):1391-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20532926</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Expert Rev Vaccines. 2011 Aug;10(8):1183-94</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21854311</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Infect Dis. 2011 Nov 15;204(10):1491-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21957153</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2012;7(1):e30252</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22279575</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Vaccine. 2012 Feb 8;30(7):1388-96</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22192847</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Influenza Other Respir Viruses. 2012 Mar;6(2):90-100</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21749672</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2012 May;86(9):5089-98</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22379093</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2012 May;86(10):5953-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22438541</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Appl Microbiol Biotechnol. 2012 Jun;94(5):1173-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22415544</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Expert Rev Vaccines. 2012 May;11(5):587-94</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22827244</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2010;5(12):e15559</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21203523</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2000 May 23;97(11):6108-13</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">10801978</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Med Virol. 2001 Sep;65(1):171-7</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">11505460</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Virology. 2003 Jan 5;305(1):192-200</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">12504552</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Scand J Immunol. 2004 Jan;59(1):1-15</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">14723616</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Virus Res. 2004 Jul;103(1-2):91-5</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15163495</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Vopr Virusol. 1965 Jan-Feb;10(1):67-73</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">5865829</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Clin Microbiol. 1986 Jan;23(1):66-72</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">3700610</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Vopr Virusol. 1986 Jul-Aug;31(4):411-4</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">2945324</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Vopr Virusol. 1991 Nov-Dec;36(6):472-4</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">1785181</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Infect Dis. 1993 Oct;168(4):881-7</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">8376833</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Gen Virol. 1995 Jun;76 ( Pt 6):1521-5</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">7782782</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Bull World Health Organ. 1996;74(1):77-84</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">8653819</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Expert Rev Vaccines. 2004 Dec;3(6):643-54</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15606348</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Vet Rec. 2005 Aug 6;157(6):159-64</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16085721</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Jpn J Infect Dis. 2005 Aug;58(4):195-207</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16116250</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Emerg Infect Dis. 2005 Oct;11(10):1515-21</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16318689</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Vaccine. 2006 Nov 10;24(44-46):6588-93</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17030078</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Vaccine. 2006 Nov 17;24(47-48):6859-66</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17050041</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS Med. 2006 Sep;3(9):e360</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16968127</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Immunol. 2007 Jan 15;178(2):1030-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17202366</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Clin Microbiol Rev. 2007 Apr;20(2):243-67</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17428885</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>N Engl J Med. 2008 Jan 17;358(3):261-73</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18199865</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2008 Feb;82(3):1350-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18032492</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS Pathog. 2008 May;4(5):e1000072</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18497857</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2009;4(2):e4436</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19209231</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Expert Rev Vaccines. 2009 Apr;8(4):401-23</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19348557</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Curr Protoc Microbiol. 2009 May;Chapter 15:Unit 15G.3</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19412911</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Influenza Other Respir Viruses. 2008 Nov;2(6):203-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19453396</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Vaccine. 2009 Jun 8;27(28):3744-53</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19464558</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2009 Aug;83(16):8131-40</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19493997</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Vaccine. 2009 Aug 6;27(36):4953-60</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19540952</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Wkly Epidemiol Rec. 2010 Mar 12;85(11):100-7</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20229648</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Avian Dis. 2010 Mar;54(1 Suppl):329-34</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20521654</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2010 Oct;84(20):10918-22</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20686037</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Crit Rev Microbiol. 2011 May;37(2):157-65</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21438845</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
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