Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers
Identifieur interne : 002614 ( Main/Exploration ); précédent : 002613; suivant : 002615Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers
Auteurs : C. W. Potter [Royaume-Uni] ; R. Jennings [Royaume-Uni] ; A. Clark [Royaume-Uni] ; M. Ali [Royaume-Uni]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 1983.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Anticorps antiviraux.
- effets indésirables : Vaccins antigrippaux.
- immunologie : Carnivora, Furets, Grippe humaine, Nez, Vaccins antigrippaux.
- Animaux, Humains, Température du corps, Vaccination, Vaccins atténués.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Influenza Vaccines.
- chemical , analysis : Antibodies, Viral.
- immunology : Carnivora, Ferrets, Influenza Vaccines, Influenza, Human, Nose.
- Teeft :
- Animals, Antibody response, Antibody responses, Attenuated, Attenuated influenza, Body Temperature, Clinical reactions, Double infection, Eidm, Eidso, Eidsoof, Hlnl, Humans, Infection, Influenza, Influenza virus, Influenza virus vaccines, Influenza viruses, Inoculated, Inoculation, Local antibody response, Nasal, Nasal washes, Nasal washings, Neutralising antibody, Potter, Protein concentration, Serological evidence, Serum specimens, Significant rise, Temperature response, Vaccination, Vaccine, Vaccines, Attenuated, Virus, Virus antigens, Virus infection, Virus inoculation, Virus strain, Virus strains, Volunteer, Volunteers inoculated.
Abstract
The effects of simultaneous inoculation with two attenuated influenza A viruses was studied in ferrets and volunteers. Groups of ferrets were inoculated with an influenza A (H3N2) or (H1N1), virus or a combination of both viruses: The temperature response, serum and local antibody response, and the change in nasal wash protein concentration was determined. The results showed that both viruses were attenuated for ferrets, and that inoculation with both viruses together did not cause clinical reactions. Serological studies on paired serum samples obtained from ferrets showed that both viruses when given separately infected all the inoculated animals; however, dual infection resulted in all ferrets being infected with the influenza A (H3N2) virus strain, but this infection interfered with infection by the influenza A (H1N1) strain. Similar investigations were carried out in volunteers. Again, the clinical reactions and temperature response of volunteers to infection by one or other of the viruses showed both strains to be attenuated for man even when given together. In addition, no adverse clinical reactions were seen in volunteers inoculated with both viruses simultaneously. Serum antibody studies showed that infection by influenza A (H1N1) virus interfered with infection by the influenza A (H2N2) virus strain. These results show evidence of interference by influenza A viruses; however, the direction of interference was one‐way, and differed for ferrets and for volunteers.
Url:
DOI: 10.1002/jmv.1890110110
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000186
- to stream Istex, to step Curation: 000186
- to stream Istex, to step Checkpoint: 001272
- to stream PubMed, to step Corpus: 000549
- to stream PubMed, to step Curation: 000549
- to stream PubMed, to step Checkpoint: 000473
- to stream Ncbi, to step Merge: 001221
- to stream Ncbi, to step Curation: 001221
- to stream Ncbi, to step Checkpoint: 001221
- to stream Main, to step Merge: 002748
- to stream Main, to step Curation: 002614
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers</title><author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name></author><author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name></author><author><name sortKey="Clark, A" sort="Clark, A" uniqKey="Clark A" first="A." last="Clark">A. Clark</name></author><author><name sortKey="Ali, M" sort="Ali, M" uniqKey="Ali M" first="M." last="Ali">M. Ali</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:4CEF7EF711AF279720955371F8D0E1F59835CA77</idno><date when="1983" year="1983">1983</date><idno type="doi">10.1002/jmv.1890110110</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-PR55SC8V-Q/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000186</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000186</idno><idno type="wicri:Area/Istex/Curation">000186</idno><idno type="wicri:Area/Istex/Checkpoint">001272</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001272</idno><idno type="wicri:doubleKey">0146-6615:1983:Potter C:interference:following:dual</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:6834013</idno><idno type="wicri:Area/PubMed/Corpus">000549</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000549</idno><idno type="wicri:Area/PubMed/Curation">000549</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000549</idno><idno type="wicri:Area/PubMed/Checkpoint">000473</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000473</idno><idno type="wicri:Area/Ncbi/Merge">001221</idno><idno type="wicri:Area/Ncbi/Curation">001221</idno><idno type="wicri:Area/Ncbi/Checkpoint">001221</idno><idno type="wicri:doubleKey">0146-6615:1983:Potter C:interference:following:dual</idno><idno type="wicri:Area/Main/Merge">002748</idno><idno type="wicri:Area/Main/Curation">002614</idno><idno type="wicri:Area/Main/Exploration">002614</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers</title><author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Virology, University of Sheffield Medical School, Sheffield</wicri:cityArea></affiliation></author><author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Virology, University of Sheffield Medical School, Sheffield</wicri:cityArea></affiliation></author><author><name sortKey="Clark, A" sort="Clark, A" uniqKey="Clark A" first="A." last="Clark">A. Clark</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Virology, University of Sheffield Medical School, Sheffield</wicri:cityArea></affiliation></author><author><name sortKey="Ali, M" sort="Ali, M" uniqKey="Ali M" first="M." last="Ali">M. Ali</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Virology, University of Sheffield Medical School, Sheffield</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">11</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="77">77</biblScope><biblScope unit="page" to="86">86</biblScope><biblScope unit="page-count">10</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1983">1983</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (analysis)</term><term>Body Temperature</term><term>Carnivora (immunology)</term><term>Ferrets (immunology)</term><term>Humans</term><term>Influenza Vaccines (adverse effects)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (immunology)</term><term>Nose (immunology)</term><term>Vaccination</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (analyse)</term><term>Carnivora (immunologie)</term><term>Furets (immunologie)</term><term>Grippe humaine (immunologie)</term><term>Humains</term><term>Nez (immunologie)</term><term>Température du corps</term><term>Vaccination</term><term>Vaccins antigrippaux (effets indésirables)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Carnivora</term><term>Furets</term><term>Grippe humaine</term><term>Nez</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Carnivora</term><term>Ferrets</term><term>Influenza Vaccines</term><term>Influenza, Human</term><term>Nose</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Animals</term><term>Antibody response</term><term>Antibody responses</term><term>Attenuated</term><term>Attenuated influenza</term><term>Body Temperature</term><term>Clinical reactions</term><term>Double infection</term><term>Eidm</term><term>Eidso</term><term>Eidsoof</term><term>Hlnl</term><term>Humans</term><term>Infection</term><term>Influenza</term><term>Influenza virus</term><term>Influenza virus vaccines</term><term>Influenza viruses</term><term>Inoculated</term><term>Inoculation</term><term>Local antibody response</term><term>Nasal</term><term>Nasal washes</term><term>Nasal washings</term><term>Neutralising antibody</term><term>Potter</term><term>Protein concentration</term><term>Serological evidence</term><term>Serum specimens</term><term>Significant rise</term><term>Temperature response</term><term>Vaccination</term><term>Vaccine</term><term>Vaccines, Attenuated</term><term>Virus</term><term>Virus antigens</term><term>Virus infection</term><term>Virus inoculation</term><term>Virus strain</term><term>Virus strains</term><term>Volunteer</term><term>Volunteers inoculated</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Température du corps</term><term>Vaccination</term><term>Vaccins atténués</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of simultaneous inoculation with two attenuated influenza A viruses was studied in ferrets and volunteers. Groups of ferrets were inoculated with an influenza A (H3N2) or (H1N1), virus or a combination of both viruses: The temperature response, serum and local antibody response, and the change in nasal wash protein concentration was determined. The results showed that both viruses were attenuated for ferrets, and that inoculation with both viruses together did not cause clinical reactions. Serological studies on paired serum samples obtained from ferrets showed that both viruses when given separately infected all the inoculated animals; however, dual infection resulted in all ferrets being infected with the influenza A (H3N2) virus strain, but this infection interfered with infection by the influenza A (H1N1) strain. Similar investigations were carried out in volunteers. Again, the clinical reactions and temperature response of volunteers to infection by one or other of the viruses showed both strains to be attenuated for man even when given together. In addition, no adverse clinical reactions were seen in volunteers inoculated with both viruses simultaneously. Serum antibody studies showed that infection by influenza A (H1N1) virus interfered with infection by the influenza A (H2N2) virus strain. These results show evidence of interference by influenza A viruses; however, the direction of interference was one‐way, and differed for ferrets and for volunteers.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name></region><name sortKey="Ali, M" sort="Ali, M" uniqKey="Ali M" first="M." last="Ali">M. Ali</name><name sortKey="Clark, A" sort="Clark, A" uniqKey="Clark A" first="A." last="Clark">A. Clark</name><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002614 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002614 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:4CEF7EF711AF279720955371F8D0E1F59835CA77
|texte= Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers
}}
| This area was generated with Dilib version V0.6.33. |  |