Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers
Identifieur interne : 000186 ( Istex/Corpus ); précédent : 000185; suivant : 000187Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers
Auteurs : C. W. Potter ; R. Jennings ; A. Clark ; M. AliSource :
- Journal of Medical Virology [ 0146-6615 ] ; 1983.
English descriptors
- Teeft :
- Antibody response, Antibody responses, Attenuated, Attenuated influenza, Clinical reactions, Double infection, Eidm, Eidso, Eidsoof, Hlnl, Infection, Influenza, Influenza virus, Influenza virus vaccines, Influenza viruses, Inoculated, Inoculation, Local antibody response, Nasal, Nasal washes, Nasal washings, Neutralising antibody, Potter, Protein concentration, Serological evidence, Serum specimens, Significant rise, Temperature response, Vaccine, Virus, Virus antigens, Virus infection, Virus inoculation, Virus strain, Virus strains, Volunteer, Volunteers inoculated.
Abstract
The effects of simultaneous inoculation with two attenuated influenza A viruses was studied in ferrets and volunteers. Groups of ferrets were inoculated with an influenza A (H3N2) or (H1N1), virus or a combination of both viruses: The temperature response, serum and local antibody response, and the change in nasal wash protein concentration was determined. The results showed that both viruses were attenuated for ferrets, and that inoculation with both viruses together did not cause clinical reactions. Serological studies on paired serum samples obtained from ferrets showed that both viruses when given separately infected all the inoculated animals; however, dual infection resulted in all ferrets being infected with the influenza A (H3N2) virus strain, but this infection interfered with infection by the influenza A (H1N1) strain. Similar investigations were carried out in volunteers. Again, the clinical reactions and temperature response of volunteers to infection by one or other of the viruses showed both strains to be attenuated for man even when given together. In addition, no adverse clinical reactions were seen in volunteers inoculated with both viruses simultaneously. Serum antibody studies showed that infection by influenza A (H1N1) virus interfered with infection by the influenza A (H2N2) virus strain. These results show evidence of interference by influenza A viruses; however, the direction of interference was one‐way, and differed for ferrets and for volunteers.
Url:
DOI: 10.1002/jmv.1890110110
Links to Exploration step
ISTEX:4CEF7EF711AF279720955371F8D0E1F59835CA77Le document en format XML
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Clark</name><affiliation><mods:affiliation>Department of Virology, University of Sheffield Medical School, Sheffield, England</mods:affiliation></affiliation></author><author><name sortKey="Ali, M" sort="Ali, M" uniqKey="Ali M" first="M." last="Ali">M. Ali</name><affiliation><mods:affiliation>Department of Virology, University of Sheffield Medical School, Sheffield, England</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:4CEF7EF711AF279720955371F8D0E1F59835CA77</idno><date when="1983" year="1983">1983</date><idno type="doi">10.1002/jmv.1890110110</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-PR55SC8V-Q/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000186</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000186</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers</title><author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name><affiliation><mods:affiliation>Department of Virology, University of Sheffield Medical School, Sheffield, England</mods:affiliation></affiliation></author><author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name><affiliation><mods:affiliation>Department of Virology, University of Sheffield Medical School, Sheffield, England</mods:affiliation></affiliation></author><author><name sortKey="Clark, A" sort="Clark, A" uniqKey="Clark A" first="A." last="Clark">A. Clark</name><affiliation><mods:affiliation>Department of Virology, University of Sheffield Medical School, Sheffield, England</mods:affiliation></affiliation></author><author><name sortKey="Ali, M" sort="Ali, M" uniqKey="Ali M" first="M." last="Ali">M. Ali</name><affiliation><mods:affiliation>Department of Virology, University of Sheffield Medical School, Sheffield, England</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">11</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="77">77</biblScope><biblScope unit="page" to="86">86</biblScope><biblScope unit="page-count">10</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1983">1983</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antibody response</term><term>Antibody responses</term><term>Attenuated</term><term>Attenuated influenza</term><term>Clinical reactions</term><term>Double infection</term><term>Eidm</term><term>Eidso</term><term>Eidsoof</term><term>Hlnl</term><term>Infection</term><term>Influenza</term><term>Influenza virus</term><term>Influenza virus vaccines</term><term>Influenza viruses</term><term>Inoculated</term><term>Inoculation</term><term>Local antibody response</term><term>Nasal</term><term>Nasal washes</term><term>Nasal washings</term><term>Neutralising antibody</term><term>Potter</term><term>Protein concentration</term><term>Serological evidence</term><term>Serum specimens</term><term>Significant rise</term><term>Temperature response</term><term>Vaccine</term><term>Virus</term><term>Virus antigens</term><term>Virus infection</term><term>Virus inoculation</term><term>Virus strain</term><term>Virus strains</term><term>Volunteer</term><term>Volunteers inoculated</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of simultaneous inoculation with two attenuated influenza A viruses was studied in ferrets and volunteers. Groups of ferrets were inoculated with an influenza A (H3N2) or (H1N1), virus or a combination of both viruses: The temperature response, serum and local antibody response, and the change in nasal wash protein concentration was determined. The results showed that both viruses were attenuated for ferrets, and that inoculation with both viruses together did not cause clinical reactions. Serological studies on paired serum samples obtained from ferrets showed that both viruses when given separately infected all the inoculated animals; however, dual infection resulted in all ferrets being infected with the influenza A (H3N2) virus strain, but this infection interfered with infection by the influenza A (H1N1) strain. Similar investigations were carried out in volunteers. Again, the clinical reactions and temperature response of volunteers to infection by one or other of the viruses showed both strains to be attenuated for man even when given together. In addition, no adverse clinical reactions were seen in volunteers inoculated with both viruses simultaneously. Serum antibody studies showed that infection by influenza A (H1N1) virus interfered with infection by the influenza A (H2N2) virus strain. 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Groups of ferrets were inoculated with an influenza A (H3N2) or (H1N1), virus or a combination of both viruses: The temperature response, serum and local antibody response, and the change in nasal wash protein concentration was determined. The results showed that both viruses were attenuated for ferrets, and that inoculation with both viruses together did not cause clinical reactions. Serological studies on paired serum samples obtained from ferrets showed that both viruses when given separately infected all the inoculated animals; however, dual infection resulted in all ferrets being infected with the influenza A (H3N2) virus strain, but this infection interfered with infection by the influenza A (H1N1) strain. Similar investigations were carried out in volunteers. Again, the clinical reactions and temperature response of volunteers to infection by one or other of the viruses showed both strains to be attenuated for man even when given together. In addition, no adverse clinical reactions were seen in volunteers inoculated with both viruses simultaneously. Serum antibody studies showed that infection by influenza A (H1N1) virus interfered with infection by the influenza A (H2N2) virus strain. These results show evidence of interference by influenza A viruses; however, the direction of interference was one‐way, and differed for ferrets and for volunteers.</abstract><qualityIndicators><score>8.401</score><pdfWordCount>3737</pdfWordCount><pdfCharCount>22977</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>504 x 720 pts</pdfPageSize><pdfWordsPerPage>374</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>222</abstractWordCount><abstractCharCount>1495</abstractCharCount><keywordCount>3</keywordCount></qualityIndicators><title>Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers</title><pmid><json:string>6834013</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Medical Virology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1096-9071</json:string></doi><issn><json:string>0146-6615</json:string></issn><eissn><json:string>1096-9071</json:string></eissn><publisherId><json:string>JMV</json:string></publisherId><volume>11</volume><issue>1</issue><pages><first>77</first><last>86</last><total>10</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Article</value></json:item><json:item><value>Articles</value></json:item></subject></host><namedEntities><unitex><date><json:string>37S</json:string><json:string>1976</json:string><json:string>1983</json:string><json:string>1977</json:string></date><geogName></geogName><orgName><json:string>World Health Organization</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>I. 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W.</forename><surname>Potter</surname></persName><affiliation><orgName type="department">Department of Virology</orgName><orgName type="institution">University of Sheffield Medical School</orgName><address><addrLine>Sheffield</addrLine><addrLine>England</addrLine><country key="GB" xml:lang="en">UNITED KINGDOM</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">R.</forename><surname>Jennings</surname></persName><affiliation><orgName type="department">Department of Virology</orgName><orgName type="institution">University of Sheffield Medical School</orgName><address><addrLine>Sheffield</addrLine><addrLine>England</addrLine><country key="GB" xml:lang="en">UNITED KINGDOM</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">A.</forename><surname>Clark</surname></persName><affiliation><orgName type="department">Department of Virology</orgName><orgName type="institution">University of Sheffield Medical School</orgName><address><addrLine>Sheffield</addrLine><addrLine>England</addrLine><country key="GB" xml:lang="en">UNITED KINGDOM</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">M.</forename><surname>Ali</surname></persName><affiliation><orgName type="department">Department of Virology</orgName><orgName type="institution">University of Sheffield Medical School</orgName><address><addrLine>Sheffield</addrLine><addrLine>England</addrLine><country key="GB" xml:lang="en">UNITED KINGDOM</country></address></affiliation></author><idno type="istex">4CEF7EF711AF279720955371F8D0E1F59835CA77</idno><idno type="ark">ark:/67375/WNG-PR55SC8V-Q</idno><idno type="DOI">10.1002/jmv.1890110110</idno><idno type="unit">JMV1890110110</idno><idno type="toTypesetVersion">file:JMV.JMV1890110110.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="pISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><idno type="book-DOI">10.1002/(ISSN)1096-9071</idno><idno type="book-part-DOI">10.1002/jmv.v11:1</idno><idno type="product">JMV</idno><imprint><biblScope unit="vol">11</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="77">77</biblScope><biblScope unit="page" to="86">86</biblScope><biblScope unit="page-count">10</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1983"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
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Serological studies on paired serum samples obtained from ferrets showed that both viruses when given separately infected all the inoculated animals; however, dual infection resulted in all ferrets being infected with the influenza A (H3N2) virus strain, but this infection interfered with infection by the influenza A (H1N1) strain. Similar investigations were carried out in volunteers. Again, the clinical reactions and temperature response of volunteers to infection by one or other of the viruses showed both strains to be attenuated for man even when given together. In addition, no adverse clinical reactions were seen in volunteers inoculated with both viruses simultaneously. Serum antibody studies showed that infection by influenza A (H1N1) virus interfered with infection by the influenza A (H2N2) virus strain. 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Virol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi origin="wiley" registered="yes">10.1002/jmv.v11:1</doi><numberingGroup><numbering type="journalVolume" number="11">11</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="1983">1983</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="10" status="forIssue"><doi origin="wiley" registered="yes">10.1002/jmv.1890110110</doi><idGroup><id type="unit" value="JMV1890110110"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="articleCategory">Article</title><title type="tocHeading1">Articles</title></titleGroup><copyright ownership="publisher">Copyright © 1983 Wiley‐Liss, Inc., A Wiley Company</copyright><eventGroup><event type="manuscriptAccepted" date="1982-08-18"></event><event type="firstOnline" date="2005-12-08"></event><event type="publishedOnlineFinalForm" date="2005-12-08"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-20"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst">77</numbering><numbering type="pageLast">86</numbering></numberingGroup><linkGroup><link type="toTypesetVersion" href="file:JMV.JMV1890110110.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="18"></count></countGroup><titleGroup><title type="main" xml:lang="en">Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers</title><title type="short" xml:lang="en">Interference With Live Influenza Viruses</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>C. W.</givenNames><familyName>Potter</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>R.</givenNames><familyName>Jennings</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>A.</givenNames><familyName>Clark</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>M.</givenNames><familyName>Ali</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>Department of Virology, University of Sheffield Medical School, Sheffield, England</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">influenza</keyword><keyword xml:id="kwd2">interference</keyword><keyword xml:id="kwd3">virus vaccines</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The effects of simultaneous inoculation with two attenuated influenza A viruses was studied in ferrets and volunteers. Groups of ferrets were inoculated with an influenza A (H3N2) or (H1N1), virus or a combination of both viruses: The temperature response, serum and local antibody response, and the change in nasal wash protein concentration was determined. The results showed that both viruses were attenuated for ferrets, and that inoculation with both viruses together did not cause clinical reactions. Serological studies on paired serum samples obtained from ferrets showed that both viruses when given separately infected all the inoculated animals; however, dual infection resulted in all ferrets being infected with the influenza A (H3N2) virus strain, but this infection interfered with infection by the influenza A (H1N1) strain. Similar investigations were carried out in volunteers. Again, the clinical reactions and temperature response of volunteers to infection by one or other of the viruses showed both strains to be attenuated for man even when given together. In addition, no adverse clinical reactions were seen in volunteers inoculated with both viruses simultaneously. Serum antibody studies showed that infection by influenza A (H1N1) virus interfered with infection by the influenza A (H2N2) virus strain. These results show evidence of interference by influenza A viruses; however, the direction of interference was one‐way, and differed for ferrets and for volunteers.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Interference With Live Influenza Viruses</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers</title></titleInfo><name type="personal"><namePart type="given">C. W.</namePart><namePart type="family">Potter</namePart><affiliation>Department of Virology, University of Sheffield Medical School, Sheffield, England</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Jennings</namePart><affiliation>Department of Virology, University of Sheffield Medical School, Sheffield, England</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Clark</namePart><affiliation>Department of Virology, University of Sheffield Medical School, Sheffield, England</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Ali</namePart><affiliation>Department of Virology, University of Sheffield Medical School, Sheffield, England</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">1983</dateIssued><dateValid encoding="w3cdtf">1982-08-18</dateValid><copyrightDate encoding="w3cdtf">1983</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">18</extent></physicalDescription><abstract lang="en">The effects of simultaneous inoculation with two attenuated influenza A viruses was studied in ferrets and volunteers. Groups of ferrets were inoculated with an influenza A (H3N2) or (H1N1), virus or a combination of both viruses: The temperature response, serum and local antibody response, and the change in nasal wash protein concentration was determined. The results showed that both viruses were attenuated for ferrets, and that inoculation with both viruses together did not cause clinical reactions. Serological studies on paired serum samples obtained from ferrets showed that both viruses when given separately infected all the inoculated animals; however, dual infection resulted in all ferrets being infected with the influenza A (H3N2) virus strain, but this infection interfered with infection by the influenza A (H1N1) strain. Similar investigations were carried out in volunteers. Again, the clinical reactions and temperature response of volunteers to infection by one or other of the viruses showed both strains to be attenuated for man even when given together. In addition, no adverse clinical reactions were seen in volunteers inoculated with both viruses simultaneously. Serum antibody studies showed that infection by influenza A (H1N1) virus interfered with infection by the influenza A (H2N2) virus strain. These results show evidence of interference by influenza A viruses; however, the direction of interference was one‐way, and differed for ferrets and for volunteers.</abstract><subject lang="en"><genre>keywords</genre><topic>influenza</topic><topic>interference</topic><topic>virus vaccines</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Medical Virology</title></titleInfo><titleInfo type="abbreviated"><title>J. Med. 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Lancet 1: 294–295.</note><part><date>1978</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>294</start><end>295</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>1978</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>294</start><end>295</end></extent></part></relatedItem></relatedItem><identifier type="istex">4CEF7EF711AF279720955371F8D0E1F59835CA77</identifier><identifier type="ark">ark:/67375/WNG-PR55SC8V-Q</identifier><identifier type="DOI">10.1002/jmv.1890110110</identifier><identifier type="ArticleID">JMV1890110110</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1983 Wiley‐Liss, Inc., A Wiley Company</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-15</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-PR55SC8V-Q/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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