Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers.
Identifieur interne : 000473 ( PubMed/Checkpoint ); précédent : 000472; suivant : 000474Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers.
Auteurs : C W Potter ; R. Jennings ; A. Clark ; M. AliSource :
- Journal of medical virology [ 0146-6615 ] ; 1983.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Anticorps antiviraux.
- effets indésirables : Vaccins antigrippaux.
- immunologie : Carnivora, Furets, Grippe humaine, Nez, Vaccins antigrippaux.
- Animaux, Humains, Température du corps, Vaccination, Vaccins atténués.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Influenza Vaccines.
- chemical , analysis : Antibodies, Viral.
- immunology : Carnivora, Ferrets, Influenza Vaccines, Influenza, Human, Nose.
- Animals, Body Temperature, Humans, Vaccination, Vaccines, Attenuated.
Abstract
The effects of simultaneous inoculation with two attenuated influenza A viruses was studied in ferrets and volunteers. Groups of ferrets were inoculated with an influenza A (H3N2) or (H1N1), virus or a combination of both viruses: the temperature response, serum and local antibody response, and the change in nasal wash protein concentration was determined. The results showed that both viruses were attenuated for ferrets, and that inoculation with both viruses together did not cause clinical reactions. Serological studies on paired serum samples obtained from ferrets showed that both viruses when given separately infected all the inoculated animals; however, dual infection resulted in all ferrets being infected with the influenza A (H3N2) virus strain, but this infection interfered with infection by the influenza A (H1N1) strain. Similar investigations were carried out in volunteers. Again, the clinical reactions and temperature response of volunteers to infection by one or other of the viruses showed both strains to be attenuated for man even when given together. In addition, no adverse clinical reactions were seen in volunteers inoculated with both viruses simultaneously. Serum antibody studies showed that infection by influenza A (H1N1) virus interfered with infection by the influenza A (H2N2) virus strain. These results show evidence of interference by influenza A viruses; however, the direction of interference was one-way, and differed for ferrets and for volunteers.
DOI: 10.1002/jmv.1890110110
PubMed: 6834013
Affiliations:
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Ali</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1983">1983</date><idno type="RBID">pubmed:6834013</idno><idno type="pmid">6834013</idno><idno type="doi">10.1002/jmv.1890110110</idno><idno type="wicri:Area/PubMed/Corpus">000549</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000549</idno><idno type="wicri:Area/PubMed/Curation">000549</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000549</idno><idno type="wicri:Area/PubMed/Checkpoint">000473</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000473</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers.</title><author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C W" last="Potter">C W Potter</name></author><author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R" last="Jennings">R. Jennings</name></author><author><name sortKey="Clark, A" sort="Clark, A" uniqKey="Clark A" first="A" last="Clark">A. Clark</name></author><author><name sortKey="Ali, M" sort="Ali, M" uniqKey="Ali M" first="M" last="Ali">M. Ali</name></author></analytic><series><title level="j">Journal of medical virology</title><idno type="ISSN">0146-6615</idno><imprint><date when="1983" type="published">1983</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (analysis)</term><term>Body Temperature</term><term>Carnivora (immunology)</term><term>Ferrets (immunology)</term><term>Humans</term><term>Influenza Vaccines (adverse effects)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (immunology)</term><term>Nose (immunology)</term><term>Vaccination</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (analyse)</term><term>Carnivora (immunologie)</term><term>Furets (immunologie)</term><term>Grippe humaine (immunologie)</term><term>Humains</term><term>Nez (immunologie)</term><term>Température du corps</term><term>Vaccination</term><term>Vaccins antigrippaux (effets indésirables)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Carnivora</term><term>Furets</term><term>Grippe humaine</term><term>Nez</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Carnivora</term><term>Ferrets</term><term>Influenza Vaccines</term><term>Influenza, Human</term><term>Nose</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Body Temperature</term><term>Humans</term><term>Vaccination</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Température du corps</term><term>Vaccination</term><term>Vaccins atténués</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of simultaneous inoculation with two attenuated influenza A viruses was studied in ferrets and volunteers. Groups of ferrets were inoculated with an influenza A (H3N2) or (H1N1), virus or a combination of both viruses: the temperature response, serum and local antibody response, and the change in nasal wash protein concentration was determined. The results showed that both viruses were attenuated for ferrets, and that inoculation with both viruses together did not cause clinical reactions. Serological studies on paired serum samples obtained from ferrets showed that both viruses when given separately infected all the inoculated animals; however, dual infection resulted in all ferrets being infected with the influenza A (H3N2) virus strain, but this infection interfered with infection by the influenza A (H1N1) strain. Similar investigations were carried out in volunteers. Again, the clinical reactions and temperature response of volunteers to infection by one or other of the viruses showed both strains to be attenuated for man even when given together. In addition, no adverse clinical reactions were seen in volunteers inoculated with both viruses simultaneously. Serum antibody studies showed that infection by influenza A (H1N1) virus interfered with infection by the influenza A (H2N2) virus strain. These results show evidence of interference by influenza A viruses; however, the direction of interference was one-way, and differed for ferrets and for volunteers.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">6834013</PMID><DateCompleted><Year>1983</Year><Month>05</Month><Day>05</Day></DateCompleted><DateRevised><Year>2019</Year><Month>08</Month><Day>29</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0146-6615</ISSN><JournalIssue CitedMedium="Print"><Volume>11</Volume><Issue>1</Issue><PubDate><Year>1983</Year></PubDate></JournalIssue><Title>Journal of medical virology</Title><ISOAbbreviation>J. Med. Virol.</ISOAbbreviation></Journal><ArticleTitle>Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers.</ArticleTitle><Pagination><MedlinePgn>77-86</MedlinePgn></Pagination><Abstract><AbstractText>The effects of simultaneous inoculation with two attenuated influenza A viruses was studied in ferrets and volunteers. Groups of ferrets were inoculated with an influenza A (H3N2) or (H1N1), virus or a combination of both viruses: the temperature response, serum and local antibody response, and the change in nasal wash protein concentration was determined. The results showed that both viruses were attenuated for ferrets, and that inoculation with both viruses together did not cause clinical reactions. Serological studies on paired serum samples obtained from ferrets showed that both viruses when given separately infected all the inoculated animals; however, dual infection resulted in all ferrets being infected with the influenza A (H3N2) virus strain, but this infection interfered with infection by the influenza A (H1N1) strain. Similar investigations were carried out in volunteers. Again, the clinical reactions and temperature response of volunteers to infection by one or other of the viruses showed both strains to be attenuated for man even when given together. In addition, no adverse clinical reactions were seen in volunteers inoculated with both viruses simultaneously. Serum antibody studies showed that infection by influenza A (H1N1) virus interfered with infection by the influenza A (H2N2) virus strain. These results show evidence of interference by influenza A viruses; however, the direction of interference was one-way, and differed for ferrets and for volunteers.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Potter</LastName><ForeName>C W</ForeName><Initials>CW</Initials></Author><Author ValidYN="Y"><LastName>Jennings</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Clark</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Ali</LastName><ForeName>M</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Med Virol</MedlineTA><NlmUniqueID>7705876</NlmUniqueID><ISSNLinking>0146-6615</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014613">Vaccines, Attenuated</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001831" MajorTopicYN="N">Body Temperature</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002335" MajorTopicYN="N">Carnivora</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005289" MajorTopicYN="N">Ferrets</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009666" MajorTopicYN="N">Nose</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014613" MajorTopicYN="N">Vaccines, Attenuated</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1983</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1983</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1983</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">6834013</ArticleId><ArticleId IdType="doi">10.1002/jmv.1890110110</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Ali, M" sort="Ali, M" uniqKey="Ali M" first="M" last="Ali">M. Ali</name><name sortKey="Clark, A" sort="Clark, A" uniqKey="Clark A" first="A" last="Clark">A. Clark</name><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R" last="Jennings">R. Jennings</name><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C W" last="Potter">C W Potter</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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