Safety, Immunogencity and Efficacy of a Cold-Adapted A/Ann Arbor/6/60 (H2N2) Vaccine in Mice and Ferrets
Identifieur interne : 001044 ( Main/Exploration ); précédent : 001043; suivant : 001045Safety, Immunogencity and Efficacy of a Cold-Adapted A/Ann Arbor/6/60 (H2N2) Vaccine in Mice and Ferrets
Auteurs : Grace L. Chen [États-Unis] ; Elaine W. Lamirande [États-Unis] ; Hong Jin [États-Unis] ; George Kemble [États-Unis] ; Kanta Subbarao [États-Unis]Source :
- Virology [ 0042-6822 ] ; 2009.
Descripteurs français
- KwdFr :
- Adaptation physiologique, Animaux, Basse température, Femelle, Furets, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (virologie), Mutation, Mâle, Poumon (virologie), Réplication virale, Souris, Souris de lignée BALB C, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (immunologie), Vaccins antigrippaux (effets indésirables), Vaccins antigrippaux (immunologie), Vaccins atténués.
- MESH :
- effets indésirables : Vaccins antigrippaux.
- génétique : Sous-type H2N2 du virus de la grippe A.
- immunologie : Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux.
- virologie : Infections à Orthomyxoviridae, Poumon.
- Adaptation physiologique, Animaux, Basse température, Femelle, Furets, Infections à Orthomyxoviridae, Mutation, Mâle, Réplication virale, Souris, Souris de lignée BALB C, Vaccins atténués.
English descriptors
- KwdEn :
- Adaptation, Physiological, Animals, Cold Temperature, Female, Ferrets, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (immunology), Influenza Vaccines (adverse effects), Influenza Vaccines (immunology), Lung (virology), Male, Mice, Mice, Inbred BALB C, Mutation, Orthomyxoviridae Infections (prevention & control), Orthomyxoviridae Infections (virology), Vaccines, Attenuated, Virus Replication.
- MESH :
- chemical , adverse effects : Influenza Vaccines.
- genetics : Influenza A Virus, H2N2 Subtype.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza Vaccines.
- prevention & control : Orthomyxoviridae Infections.
- virology : Lung, Orthomyxoviridae Infections.
- Adaptation, Physiological, Animals, Cold Temperature, Female, Ferrets, Male, Mice, Mice, Inbred BALB C, Mutation, Vaccines, Attenuated, Virus Replication.
Abstract
We studied the attenuation, immunogenicity and efficacy of the cold-adapted A/Ann Arbor/6/60 (AA
Url:
DOI: 10.1016/j.virol.2009.12.003
PubMed: 20034647
PubMed Central: 2823816
Affiliations:
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Le document en format XML
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<term>Female</term>
<term>Ferrets</term>
<term>Influenza A Virus, H2N2 Subtype (genetics)</term>
<term>Influenza A Virus, H2N2 Subtype (immunology)</term>
<term>Influenza Vaccines (adverse effects)</term>
<term>Influenza Vaccines (immunology)</term>
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<term>Furets</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Infections à Orthomyxoviridae (virologie)</term>
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<term>Souris de lignée BALB C</term>
<term>Sous-type H2N2 du virus de la grippe A (génétique)</term>
<term>Sous-type H2N2 du virus de la grippe A (immunologie)</term>
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<term>Vaccins antigrippaux (immunologie)</term>
<term>Vaccins atténués</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">We studied the attenuation, immunogenicity and efficacy of the cold-adapted A/Ann Arbor/6/60 (AA<italic>ca</italic>
) (H2N2) virus in mice and ferrets to evaluate its' use in the event of an H2 influenza pandemic. The AA<italic>ca</italic>
virus was restricted in replication in the respiratory tract of mice and ferrets. In mice, 2 doses of vaccine elicited a > 4-fold rise in hemagglutination-inhibition (HAI) titer and resulted in complete inhibition of viral replication following lethal homologous wild-type virus challenge. In ferrets, a single dose of the vaccine elicited a > 4-fold rise in HAI titer and conferred complete protection against homologous wild-type virus challenge in the upper respiratory tract. In both mice and ferrets, the AA<italic>ca</italic>
virus provided significant protection from challenge with heterologous H2 virus challenge in the respiratory tract. The AA<italic>ca</italic>
vaccine is safe, immunogenic and efficacious against homologous and heterologous challenge in mice and ferrets, supporting the evaluation of this vaccine in clinical trials.</p>
</div>
</front>
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<name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name>
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<name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W" last="Lamirande">Elaine W. Lamirande</name>
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