Safety, Immunogencity and Efficacy of a Cold-Adapted A/Ann Arbor/6/60 (H2N2) Vaccine in Mice and Ferrets
Identifieur interne : 000523 ( Pmc/Curation ); précédent : 000522; suivant : 000524Safety, Immunogencity and Efficacy of a Cold-Adapted A/Ann Arbor/6/60 (H2N2) Vaccine in Mice and Ferrets
Auteurs : Grace L. Chen [États-Unis] ; Elaine W. Lamirande [États-Unis] ; Hong Jin [États-Unis] ; George Kemble [États-Unis] ; Kanta Subbarao [États-Unis]Source :
- Virology [ 0042-6822 ] ; 2009.
Abstract
We studied the attenuation, immunogenicity and efficacy of the cold-adapted A/Ann Arbor/6/60 (AA
Url:
DOI: 10.1016/j.virol.2009.12.003
PubMed: 20034647
PubMed Central: 2823816
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<front><div type="abstract" xml:lang="en"><p id="P1">We studied the attenuation, immunogenicity and efficacy of the cold-adapted A/Ann Arbor/6/60 (AA<italic>ca</italic>
) (H2N2) virus in mice and ferrets to evaluate its' use in the event of an H2 influenza pandemic. The AA<italic>ca</italic>
virus was restricted in replication in the respiratory tract of mice and ferrets. In mice, 2 doses of vaccine elicited a > 4-fold rise in hemagglutination-inhibition (HAI) titer and resulted in complete inhibition of viral replication following lethal homologous wild-type virus challenge. In ferrets, a single dose of the vaccine elicited a > 4-fold rise in HAI titer and conferred complete protection against homologous wild-type virus challenge in the upper respiratory tract. In both mice and ferrets, the AA<italic>ca</italic>
virus provided significant protection from challenge with heterologous H2 virus challenge in the respiratory tract. The AA<italic>ca</italic>
vaccine is safe, immunogenic and efficacious against homologous and heterologous challenge in mice and ferrets, supporting the evaluation of this vaccine in clinical trials.</p>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0110674</journal-id>
<journal-id journal-id-type="pubmed-jr-id">8015</journal-id>
<journal-id journal-id-type="nlm-ta">Virology</journal-id>
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<issn pub-type="epub">1096-0341</issn>
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<article-id pub-id-type="manuscript">NIHMS167498</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Safety, Immunogencity and Efficacy of a Cold-Adapted A/Ann Arbor/6/60 (H2N2) Vaccine in Mice and Ferrets</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Grace L</given-names>
</name>
<email>chengra@niaid.nih.gov</email>
<xref rid="A1" ref-type="aff">1</xref>
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<contrib contrib-type="author"><name><surname>Lamirande</surname>
<given-names>Elaine W</given-names>
</name>
<email>elamirande@niaid.nih.gov</email>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jin</surname>
<given-names>Hong</given-names>
</name>
<email>jinh@medimmune.com</email>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kemble</surname>
<given-names>George</given-names>
</name>
<email>kembleg@medimmune.com</email>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Subbarao</surname>
<given-names>Kanta</given-names>
</name>
<email>ksubbarao@niaid.nih.gov</email>
<xref rid="A1" ref-type="aff">1</xref>
<xref rid="FN1" ref-type="author-notes">§</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892</aff>
<aff id="A2"><label>2</label>
Medimmune, Mountain View, CA 94043</aff>
<author-notes><corresp id="FN1"><label>§</label>
Corresponding author: Kanta Subbarao, MD, MPH, Laboratory of Infectious Diseases, NIAID, NIH, Bldg 33, Room 3E13C.1, 33 North Drive, MSC 3203, Bethesda, MD 20892-3203, (301) 451-3839, Fax: (301) 480-5722</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>13</day>
<month>1</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>24</day>
<month>12</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="ppub"><day>1</day>
<month>3</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>3</month>
<year>2011</year>
</pub-date>
<volume>398</volume>
<issue>1</issue>
<fpage>109</fpage>
<lpage>114</lpage>
<abstract><p id="P1">We studied the attenuation, immunogenicity and efficacy of the cold-adapted A/Ann Arbor/6/60 (AA<italic>ca</italic>
) (H2N2) virus in mice and ferrets to evaluate its' use in the event of an H2 influenza pandemic. The AA<italic>ca</italic>
virus was restricted in replication in the respiratory tract of mice and ferrets. In mice, 2 doses of vaccine elicited a > 4-fold rise in hemagglutination-inhibition (HAI) titer and resulted in complete inhibition of viral replication following lethal homologous wild-type virus challenge. In ferrets, a single dose of the vaccine elicited a > 4-fold rise in HAI titer and conferred complete protection against homologous wild-type virus challenge in the upper respiratory tract. In both mice and ferrets, the AA<italic>ca</italic>
virus provided significant protection from challenge with heterologous H2 virus challenge in the respiratory tract. The AA<italic>ca</italic>
vaccine is safe, immunogenic and efficacious against homologous and heterologous challenge in mice and ferrets, supporting the evaluation of this vaccine in clinical trials.</p>
</abstract>
<kwd-group><kwd>Live attenuated influenza vaccines</kwd>
<kwd>A/Ann Arbor/6/60 (H2N2)</kwd>
</kwd-group>
<contract-num rid="AI1">ZIA AI000933-07
||AI</contract-num>
<contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor>
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