H2N2V1, Pmc, Corpus, bibRecord, 000523

Safety, Immunogencity and Efficacy of a Cold-Adapted A/Ann Arbor/6/60 (H2N2) Vaccine in Mice and Ferrets

Identifieur interne : 000523 ( Pmc/Corpus ); précédent : 000522; suivant : 000524

Safety, Immunogencity and Efficacy of a Cold-Adapted A/Ann Arbor/6/60 (H2N2) Vaccine in Mice and Ferrets

Auteurs : Grace L. Chen ; Elaine W. Lamirande ; Hong Jin ; George Kemble ; Kanta Subbarao

Source :

Virology [ 0042-6822 ] ; 2009.

RBID : PMC:2823816

Abstract

We studied the attenuation, immunogenicity and efficacy of the cold-adapted A/Ann Arbor/6/60 (AAca) (H2N2) virus in mice and ferrets to evaluate its' use in the event of an H2 influenza pandemic. The AAca virus was restricted in replication in the respiratory tract of mice and ferrets. In mice, 2 doses of vaccine elicited a > 4-fold rise in hemagglutination-inhibition (HAI) titer and resulted in complete inhibition of viral replication following lethal homologous wild-type virus challenge. In ferrets, a single dose of the vaccine elicited a > 4-fold rise in HAI titer and conferred complete protection against homologous wild-type virus challenge in the upper respiratory tract. In both mice and ferrets, the AAca virus provided significant protection from challenge with heterologous H2 virus challenge in the respiratory tract. The AAca vaccine is safe, immunogenic and efficacious against homologous and heterologous challenge in mice and ferrets, supporting the evaluation of this vaccine in clinical trials.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823816

DOI: 10.1016/j.virol.2009.12.003
PubMed: 20034647
PubMed Central: 2823816

Links to Exploration step

PMC:2823816

Le document en format XML

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<author><name sortKey="Chen, Grace L" sort="Chen, Grace L" uniqKey="Chen G" first="Grace L" last="Chen">Grace L. Chen</name>
<affiliation><nlm:aff id="A1"> Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892</nlm:aff>
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<author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W" last="Lamirande">Elaine W. Lamirande</name>
<affiliation><nlm:aff id="A1"> Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892</nlm:aff>
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<author><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name>
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<author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name>
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<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
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<series><title level="j">Virology</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">We studied the attenuation, immunogenicity and efficacy of the cold-adapted A/Ann Arbor/6/60 (AA<italic>ca</italic>
) (H2N2) virus in mice and ferrets to evaluate its' use in the event of an H2 influenza pandemic. The AA<italic>ca</italic>
 virus was restricted in replication in the respiratory tract of mice and ferrets. In mice, 2 doses of vaccine elicited a > 4-fold rise in hemagglutination-inhibition (HAI) titer and resulted in complete inhibition of viral replication following lethal homologous wild-type virus challenge. In ferrets, a single dose of the vaccine elicited a > 4-fold rise in HAI titer and conferred complete protection against homologous wild-type virus challenge in the upper respiratory tract. In both mice and ferrets, the AA<italic>ca</italic>
 virus provided significant protection from challenge with heterologous H2 virus challenge in the respiratory tract. The AA<italic>ca</italic>
 vaccine is safe, immunogenic and efficacious against homologous and heterologous challenge in mice and ferrets, supporting the evaluation of this vaccine in clinical trials.</p>
</div>
</front>
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<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">0110674</journal-id>
<journal-id journal-id-type="pubmed-jr-id">8015</journal-id>
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<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Safety, Immunogencity and Efficacy of a Cold-Adapted A/Ann Arbor/6/60 (H2N2) Vaccine in Mice and Ferrets</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Grace L</given-names>
</name>
<email>chengra@niaid.nih.gov</email>
<xref rid="A1" ref-type="aff">1</xref>
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<contrib contrib-type="author"><name><surname>Lamirande</surname>
<given-names>Elaine W</given-names>
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<email>elamirande@niaid.nih.gov</email>
<xref rid="A1" ref-type="aff">1</xref>
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<contrib contrib-type="author"><name><surname>Jin</surname>
<given-names>Hong</given-names>
</name>
<email>jinh@medimmune.com</email>
<xref rid="A2" ref-type="aff">2</xref>
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<contrib contrib-type="author"><name><surname>Kemble</surname>
<given-names>George</given-names>
</name>
<email>kembleg@medimmune.com</email>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Subbarao</surname>
<given-names>Kanta</given-names>
</name>
<email>ksubbarao@niaid.nih.gov</email>
<xref rid="A1" ref-type="aff">1</xref>
<xref rid="FN1" ref-type="author-notes">§</xref>
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<aff id="A1"><label>1</label>
 Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892</aff>
<aff id="A2"><label>2</label>
 Medimmune, Mountain View, CA 94043</aff>
<author-notes><corresp id="FN1"><label>§</label>
Corresponding author: Kanta Subbarao, MD, MPH, Laboratory of Infectious Diseases, NIAID, NIH, Bldg 33, Room 3E13C.1, 33 North Drive, MSC 3203, Bethesda, MD 20892-3203, (301) 451-3839, Fax: (301) 480-5722</corresp>
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<pub-date pub-type="nihms-submitted"><day>13</day>
<month>1</month>
<year>2010</year>
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<pub-date pub-type="epub"><day>24</day>
<month>12</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="ppub"><day>1</day>
<month>3</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>3</month>
<year>2011</year>
</pub-date>
<volume>398</volume>
<issue>1</issue>
<fpage>109</fpage>
<lpage>114</lpage>
<abstract><p id="P1">We studied the attenuation, immunogenicity and efficacy of the cold-adapted A/Ann Arbor/6/60 (AA<italic>ca</italic>
) (H2N2) virus in mice and ferrets to evaluate its' use in the event of an H2 influenza pandemic. The AA<italic>ca</italic>
 virus was restricted in replication in the respiratory tract of mice and ferrets. In mice, 2 doses of vaccine elicited a > 4-fold rise in hemagglutination-inhibition (HAI) titer and resulted in complete inhibition of viral replication following lethal homologous wild-type virus challenge. In ferrets, a single dose of the vaccine elicited a > 4-fold rise in HAI titer and conferred complete protection against homologous wild-type virus challenge in the upper respiratory tract. In both mice and ferrets, the AA<italic>ca</italic>
 virus provided significant protection from challenge with heterologous H2 virus challenge in the respiratory tract. The AA<italic>ca</italic>
 vaccine is safe, immunogenic and efficacious against homologous and heterologous challenge in mice and ferrets, supporting the evaluation of this vaccine in clinical trials.</p>
</abstract>
<kwd-group><kwd>Live attenuated influenza vaccines</kwd>
<kwd>A/Ann Arbor/6/60 (H2N2)</kwd>
</kwd-group>
<contract-num rid="AI1">ZIA AI000933-07
				||AI</contract-num>
<contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor>
</article-meta>
</front>
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Safety, Immunogencity and Efficacy of a Cold-Adapted A/Ann Arbor/6/60 (H2N2) Vaccine in Mice and Ferrets

Safety, Immunogencity and Efficacy of a Cold-Adapted A/Ann Arbor/6/60 (H2N2) Vaccine in Mice and Ferrets

Source :

Abstract

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