H2N2V1, Main, Exploration, bibRecord, 001A38

Antiviral effect of gingyo-san, a traditional chinese herbal medicine, on influenza A2 virus infection in mice

Identifieur interne : 001A38 ( Main/Exploration ); précédent : 001A37; suivant : 001A39

Antiviral effect of gingyo-san, a traditional chinese herbal medicine, on influenza A2 virus infection in mice

Auteurs : M. Kobayashi [États-Unis] ; S. M. Davis [États-Unis] ; T. Utsunomiya [États-Unis] ; R. B. Pollard [États-Unis] ; F. Suzuki [États-Unis]

Source :

The American journal of Chinese medicine : (1979) [ 0192-415X ] ; 1999.

RBID : Pascal:99-0311375

Descripteurs français

KwdFr :
- Animaux, Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Infections à Orthomyxoviridae (traitement médicamenteux), Médicaments issus de plantes chinoises (pharmacologie), Médicaments issus de plantes chinoises (usage thérapeutique), Souris, Souris de lignée BALB C, Virus de la grippe A ().
MESH :
- pharmacologie : Antiviraux, Médicaments issus de plantes chinoises.
- traitement médicamenteux : Infections à Orthomyxoviridae.
- usage thérapeutique : Antiviraux, Médicaments issus de plantes chinoises.
Pascal (Inist)
- Animaux, Grippe, Influenzavirus A, Souris, Souris de lignée BALB C, Traitement, Médecine chinoise, Plante médicinale, Etude expérimentale, Souris, Animal, Virus de la grippe A.
Wicri :
- topic : Plante médicinale.

English descriptors

KwdEn :
- Animal, Animals, Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Chinese medicine, Drugs, Chinese Herbal (pharmacology), Drugs, Chinese Herbal (therapeutic use), Experimental study, Influenza, Influenza A virus (drug effects), Influenzavirus A, Medicinal plant, Mice, Mice, Inbred BALB C, Mouse, Orthomyxoviridae Infections (drug therapy), Treatment.
MESH :
- chemical , pharmacology : Antiviral Agents, Drugs, Chinese Herbal.
- chemical , therapeutic use : Antiviral Agents, Drugs, Chinese Herbal.
- drug effects : Influenza A virus.
- drug therapy : Orthomyxoviridae Infections.
- Animals, Mice, Mice, Inbred BALB C.

Abstract

Gingyo-san is a crude drug containing extracts from 7 medicinal plants and fermented soybeans in a specific ratio. It has been used clinically in China as a therapeutic agent for the common cold. In the present study, we examined the antiviral effect of this agent on influenza virus infection in mice. Gingyo-san and its components were administered orally to mice 1 day before, then I and 4 days after the inhalation of a mouse-adopted strain of influenza A₂ (H₂N₂) virus. After infection with a 10 LD₅₀ of the virus, 100% of mice treated with 10 mg/kg of the agent survived as compared with a 0% survival of control mice treated with saline. Also, the mean survival days were increased and consolidation scores were decreased in treated mice as compared with those of control mice. Two components contained in the agent, extracts from Glycyrrhizae radix and Arctii fructus, expressed antiviral activities in mice infected with influenza virus. However, in vitro growth of influenza virus in MDCK cells or viability of the virus was not affected by these extracts or Gingyo-san. From these results Gingyo-san was shown to be an antiviral agent in mice infected with a lethal amount of a mouse-adopted strain of influenza A₂ virus.

Affiliations:

États-Unis

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Antiviral effect of gingyo-san, a traditional chinese herbal medicine, on influenza A<sub>2</sub>
 virus infection in mice</title>
<author><name sortKey="Kobayashi, M" sort="Kobayashi, M" uniqKey="Kobayashi M" first="M." last="Kobayashi">M. Kobayashi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Internal Medicine, The University of Texas Medical Branch</s1>
<s2>Galveston, Texas 77555</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Galveston, Texas 77555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Davis, S M" sort="Davis, S M" uniqKey="Davis S" first="S. M." last="Davis">S. M. Davis</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Internal Medicine, The University of Texas Medical Branch</s1>
<s2>Galveston, Texas 77555</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Galveston, Texas 77555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Utsunomiya, T" sort="Utsunomiya, T" uniqKey="Utsunomiya T" first="T." last="Utsunomiya">T. Utsunomiya</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Internal Medicine, The University of Texas Medical Branch</s1>
<s2>Galveston, Texas 77555</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Galveston, Texas 77555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pollard, R B" sort="Pollard, R B" uniqKey="Pollard R" first="R. B." last="Pollard">R. B. Pollard</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Internal Medicine, The University of Texas Medical Branch</s1>
<s2>Galveston, Texas 77555</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Galveston, Texas 77555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Suzuki, F" sort="Suzuki, F" uniqKey="Suzuki F" first="F." last="Suzuki">F. Suzuki</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Internal Medicine, The University of Texas Medical Branch</s1>
<s2>Galveston, Texas 77555</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Galveston, Texas 77555</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">99-0311375</idno>
<date when="1999">1999</date>
<idno type="stanalyst">PASCAL 99-0311375 INIST</idno>
<idno type="RBID">Pascal:99-0311375</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000075</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000139</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000075</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000075</idno>
<idno type="wicri:doubleKey">0192-415X:1999:Kobayashi M:antiviral:effect:of</idno>
<idno type="wicri:Area/Main/Merge">001A88</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:10354817</idno>
<idno type="wicri:Area/PubMed/Corpus">000375</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000375</idno>
<idno type="wicri:Area/PubMed/Curation">000375</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000375</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000342</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000342</idno>
<idno type="wicri:Area/Ncbi/Merge">000007</idno>
<idno type="wicri:Area/Ncbi/Curation">000007</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000007</idno>
<idno type="wicri:doubleKey">0192-415X:1999:Kobayashi M:antiviral:effect:of</idno>
<idno type="wicri:Area/Main/Merge">001A25</idno>
<idno type="wicri:Area/Main/Curation">001A38</idno>
<idno type="wicri:Area/Main/Exploration">001A38</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Antiviral effect of gingyo-san, a traditional chinese herbal medicine, on influenza A<sub>2</sub>
 virus infection in mice</title>
<author><name sortKey="Kobayashi, M" sort="Kobayashi, M" uniqKey="Kobayashi M" first="M." last="Kobayashi">M. Kobayashi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Internal Medicine, The University of Texas Medical Branch</s1>
<s2>Galveston, Texas 77555</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Galveston, Texas 77555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Davis, S M" sort="Davis, S M" uniqKey="Davis S" first="S. M." last="Davis">S. M. Davis</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Internal Medicine, The University of Texas Medical Branch</s1>
<s2>Galveston, Texas 77555</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Galveston, Texas 77555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Utsunomiya, T" sort="Utsunomiya, T" uniqKey="Utsunomiya T" first="T." last="Utsunomiya">T. Utsunomiya</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Internal Medicine, The University of Texas Medical Branch</s1>
<s2>Galveston, Texas 77555</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Galveston, Texas 77555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pollard, R B" sort="Pollard, R B" uniqKey="Pollard R" first="R. B." last="Pollard">R. B. Pollard</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Internal Medicine, The University of Texas Medical Branch</s1>
<s2>Galveston, Texas 77555</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Galveston, Texas 77555</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Suzuki, F" sort="Suzuki, F" uniqKey="Suzuki F" first="F." last="Suzuki">F. Suzuki</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Internal Medicine, The University of Texas Medical Branch</s1>
<s2>Galveston, Texas 77555</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Galveston, Texas 77555</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The American journal of Chinese medicine : (1979)</title>
<title level="j" type="abbreviated">Am. j. Chin. med. : (1979)</title>
<idno type="ISSN">0192-415X</idno>
<imprint><date when="1999">1999</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The American journal of Chinese medicine : (1979)</title>
<title level="j" type="abbreviated">Am. j. Chin. med. : (1979)</title>
<idno type="ISSN">0192-415X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Animals</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Chinese medicine</term>
<term>Drugs, Chinese Herbal (pharmacology)</term>
<term>Drugs, Chinese Herbal (therapeutic use)</term>
<term>Experimental study</term>
<term>Influenza</term>
<term>Influenza A virus (drug effects)</term>
<term>Influenzavirus A</term>
<term>Medicinal plant</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mouse</term>
<term>Orthomyxoviridae Infections (drug therapy)</term>
<term>Treatment</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Antiviraux (pharmacologie)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Infections à Orthomyxoviridae (traitement médicamenteux)</term>
<term>Médicaments issus de plantes chinoises (pharmacologie)</term>
<term>Médicaments issus de plantes chinoises (usage thérapeutique)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Virus de la grippe A ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Drugs, Chinese Herbal</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
<term>Drugs, Chinese Herbal</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term>
<term>Médicaments issus de plantes chinoises</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term>
<term>Médicaments issus de plantes chinoises</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
<term>Grippe</term>
<term>Influenzavirus A</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Traitement</term>
<term>Médecine chinoise</term>
<term>Plante médicinale</term>
<term>Etude expérimentale</term>
<term>Souris</term>
<term>Animal</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Plante médicinale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Gingyo-san is a crude drug containing extracts from 7 medicinal plants and fermented soybeans in a specific ratio. It has been used clinically in China as a therapeutic agent for the common cold. In the present study, we examined the antiviral effect of this agent on influenza virus infection in mice. Gingyo-san and its components were administered orally to mice 1 day before, then I and 4 days after the inhalation of a mouse-adopted strain of influenza A<sub>2</sub>
 (H<sub>2</sub>
N<sub>2</sub>
) virus. After infection with a 10 LD<sub>50</sub>
 of the virus, 100% of mice treated with 10 mg/kg of the agent survived as compared with a 0% survival of control mice treated with saline. Also, the mean survival days were increased and consolidation scores were decreased in treated mice as compared with those of control mice. Two components contained in the agent, extracts from Glycyrrhizae radix and Arctii fructus, expressed antiviral activities in mice infected with influenza virus. However, in vitro growth of influenza virus in MDCK cells or viability of the virus was not affected by these extracts or Gingyo-san. From these results Gingyo-san was shown to be an antiviral agent in mice infected with a lethal amount of a mouse-adopted strain of influenza A<sub>2</sub>
 virus.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Kobayashi, M" sort="Kobayashi, M" uniqKey="Kobayashi M" first="M." last="Kobayashi">M. Kobayashi</name>
</noRegion>
<name sortKey="Davis, S M" sort="Davis, S M" uniqKey="Davis S" first="S. M." last="Davis">S. M. Davis</name>
<name sortKey="Pollard, R B" sort="Pollard, R B" uniqKey="Pollard R" first="R. B." last="Pollard">R. B. Pollard</name>
<name sortKey="Suzuki, F" sort="Suzuki, F" uniqKey="Suzuki F" first="F." last="Suzuki">F. Suzuki</name>
<name sortKey="Utsunomiya, T" sort="Utsunomiya, T" uniqKey="Utsunomiya T" first="T." last="Utsunomiya">T. Utsunomiya</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A38 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A38 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:99-0311375
   |texte=   Antiviral effect of gingyo-san, a traditional chinese herbal medicine, on influenza A2 virus infection in mice
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

Antiviral effect of gingyo-san, a traditional chinese herbal medicine, on influenza A2 virus infection in mice

Antiviral effect of gingyo-san, a traditional chinese herbal medicine, on influenza A2 virus infection in mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.