Antiviral effect of gingyo-san, a traditional Chinese herbal medicine, on influenza A2 virus infection in mice.
Identifieur interne : 000007 ( Ncbi/Merge ); précédent : 000006; suivant : 000008Antiviral effect of gingyo-san, a traditional Chinese herbal medicine, on influenza A2 virus infection in mice.
Auteurs : M. Kobayashi [États-Unis] ; S M Davis ; T. Utsunomiya ; R B Pollard ; F. SuzukiSource :
- The American journal of Chinese medicine [ 0192-415X ] ; 1999.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Infections à Orthomyxoviridae (traitement médicamenteux), Médicaments issus de plantes chinoises (pharmacologie), Médicaments issus de plantes chinoises (usage thérapeutique), Souris, Souris de lignée BALB C, Virus de la grippe A ().
- MESH :
- pharmacologie : Antiviraux, Médicaments issus de plantes chinoises.
- traitement médicamenteux : Infections à Orthomyxoviridae.
- usage thérapeutique : Antiviraux, Médicaments issus de plantes chinoises.
- Animaux, Souris, Souris de lignée BALB C, Virus de la grippe A.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antiviral Agents, Drugs, Chinese Herbal.
- chemical , therapeutic use : Antiviral Agents, Drugs, Chinese Herbal.
- drug effects : Influenza A virus.
- drug therapy : Orthomyxoviridae Infections.
- Animals, Mice, Mice, Inbred BALB C.
Abstract
Gingyo-san is a crude drug containing extracts from 7 medicinal plants and fermented soybeans in a specific ratio. It has been used clinically in China as a therapeutic agent for the common cold. In the present study, we examined the antiviral effect of this agent on influenza virus infection in mice. Gingyo-san and its components were administered orally to mice 1 day before, then 1 and 4 days after the inhalation of a mouse-adopted strain of influenza A2 (H2N2) virus. After infection with a 10 LD50 of the virus, 100% of mice treated with 10 mg/kg of the agent survived as compared with a 0% survival of control mice treated with saline. Also, the mean survival days were increased and consolidation scores were decreased in treated mice as compared with those of control mice. Two components contained in the agent, extracts from Glycyrrhizae radix and Arctii fructus, expressed antiviral activities in mice infected with influenza virus. However, in vitro growth of influenza virus in MDCK cells or viability of the virus was not affected by these extracts or Gingyo-san. From these results Gingyo-san was shown to be an antiviral agent in mice infected with a lethal amount of a mouse-adopted strain of influenza A2 virus.
DOI: 10.1142/S0192415X99000082
PubMed: 10354817
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pubmed:10354817Le document en format XML
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Utsunomiya</name></author><author><name sortKey="Pollard, R B" sort="Pollard, R B" uniqKey="Pollard R" first="R B" last="Pollard">R B Pollard</name></author><author><name sortKey="Suzuki, F" sort="Suzuki, F" uniqKey="Suzuki F" first="F" last="Suzuki">F. 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Suzuki</name></author></analytic><series><title level="j">The American journal of Chinese medicine</title><idno type="ISSN">0192-415X</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (therapeutic use)</term><term>Drugs, Chinese Herbal (pharmacology)</term><term>Drugs, Chinese Herbal (therapeutic use)</term><term>Influenza A virus (drug effects)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Orthomyxoviridae Infections (drug therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Infections à Orthomyxoviridae (traitement médicamenteux)</term><term>Médicaments issus de plantes chinoises (pharmacologie)</term><term>Médicaments issus de plantes chinoises (usage thérapeutique)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Virus de la grippe A ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Drugs, Chinese Herbal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Drugs, Chinese Herbal</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Médicaments issus de plantes chinoises</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Médicaments issus de plantes chinoises</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gingyo-san is a crude drug containing extracts from 7 medicinal plants and fermented soybeans in a specific ratio. It has been used clinically in China as a therapeutic agent for the common cold. In the present study, we examined the antiviral effect of this agent on influenza virus infection in mice. Gingyo-san and its components were administered orally to mice 1 day before, then 1 and 4 days after the inhalation of a mouse-adopted strain of influenza A2 (H2N2) virus. After infection with a 10 LD50 of the virus, 100% of mice treated with 10 mg/kg of the agent survived as compared with a 0% survival of control mice treated with saline. Also, the mean survival days were increased and consolidation scores were decreased in treated mice as compared with those of control mice. Two components contained in the agent, extracts from Glycyrrhizae radix and Arctii fructus, expressed antiviral activities in mice infected with influenza virus. However, in vitro growth of influenza virus in MDCK cells or viability of the virus was not affected by these extracts or Gingyo-san. From these results Gingyo-san was shown to be an antiviral agent in mice infected with a lethal amount of a mouse-adopted strain of influenza A2 virus.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10354817</PMID><DateCompleted><Year>1999</Year><Month>07</Month><Day>21</Day></DateCompleted><DateRevised><Year>2005</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0192-415X</ISSN><JournalIssue CitedMedium="Print"><Volume>27</Volume><Issue>1</Issue><PubDate><Year>1999</Year></PubDate></JournalIssue><Title>The American journal of Chinese medicine</Title><ISOAbbreviation>Am. J. Chin. 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Also, the mean survival days were increased and consolidation scores were decreased in treated mice as compared with those of control mice. Two components contained in the agent, extracts from Glycyrrhizae radix and Arctii fructus, expressed antiviral activities in mice infected with influenza virus. However, in vitro growth of influenza virus in MDCK cells or viability of the virus was not affected by these extracts or Gingyo-san. 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Suzuki</name><name sortKey="Utsunomiya, T" sort="Utsunomiya, T" uniqKey="Utsunomiya T" first="T" last="Utsunomiya">T. Utsunomiya</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Kobayashi, M" sort="Kobayashi, M" uniqKey="Kobayashi M" first="M" last="Kobayashi">M. Kobayashi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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