H2N2V1, PascalFrancis, Corpus, bibRecord, 000075

Antiviral effect of gingyo-san, a traditional chinese herbal medicine, on influenza A2 virus infection in mice

Identifieur interne : 000075 ( PascalFrancis/Corpus ); précédent : 000074; suivant : 000076

Antiviral effect of gingyo-san, a traditional chinese herbal medicine, on influenza A2 virus infection in mice

Auteurs : M. Kobayashi ; S. M. Davis ; T. Utsunomiya ; R. B. Pollard ; F. Suzuki

Source :

The American journal of Chinese medicine : (1979) [ 0192-415X ] ; 1999.

RBID : Pascal:99-0311375

Descripteurs français

Pascal (Inist)
- Grippe, Influenzavirus A, Traitement, Médecine chinoise, Plante médicinale, Etude expérimentale, Souris, Animal.

English descriptors

KwdEn :
- Animal, Chinese medicine, Experimental study, Influenza, Influenzavirus A, Medicinal plant, Mouse, Treatment.

Abstract

Gingyo-san is a crude drug containing extracts from 7 medicinal plants and fermented soybeans in a specific ratio. It has been used clinically in China as a therapeutic agent for the common cold. In the present study, we examined the antiviral effect of this agent on influenza virus infection in mice. Gingyo-san and its components were administered orally to mice 1 day before, then I and 4 days after the inhalation of a mouse-adopted strain of influenza A₂ (H₂N₂) virus. After infection with a 10 LD₅₀ of the virus, 100% of mice treated with 10 mg/kg of the agent survived as compared with a 0% survival of control mice treated with saline. Also, the mean survival days were increased and consolidation scores were decreased in treated mice as compared with those of control mice. Two components contained in the agent, extracts from Glycyrrhizae radix and Arctii fructus, expressed antiviral activities in mice infected with influenza virus. However, in vitro growth of influenza virus in MDCK cells or viability of the virus was not affected by these extracts or Gingyo-san. From these results Gingyo-san was shown to be an antiviral agent in mice infected with a lethal amount of a mouse-adopted strain of influenza A₂ virus.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 AJCMBA`
A03		`1`		`@0 Am. j. Chin. med. : (1979)`
A05				`@2 27`
A06				`@2 1`
A08	`01`	`1`	`ENG`	`@1 Antiviral effect of gingyo-san, a traditional chinese herbal medicine, on influenza A₂ virus infection in mice`
A11	`01`	`1`		`@1 KOBAYASHI (M.)`
A11	`02`	`1`		`@1 DAVIS (S. M.)`
A11	`03`	`1`		`@1 UTSUNOMIYA (T.)`
A11	`04`	`1`		`@1 POLLARD (R. B.)`
A11	`05`	`1`		`@1 SUZUKI (F.)`
A14	`01`			`@1 Department of Internal Medicine, The University of Texas Medical Branch @2 Galveston, Texas 77555 @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut.`
A20				`@1 53-62`
A21				`@1 1999`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 16517 @5 354000084223480070`
A44				`@0 0000 @1 © 1999 INIST-CNRS. All rights reserved.`
A45				`@0 21 ref.`
A47	`01`	`1`		`@0 99-0311375`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 The American journal of Chinese medicine : (1979)`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Gingyo-san is a crude drug containing extracts from 7 medicinal plants and fermented soybeans in a specific ratio. It has been used clinically in China as a therapeutic agent for the common cold. In the present study, we examined the antiviral effect of this agent on influenza virus infection in mice. Gingyo-san and its components were administered orally to mice 1 day before, then I and 4 days after the inhalation of a mouse-adopted strain of influenza A₂ (H₂N₂) virus. After infection with a 10 LD₅₀ of the virus, 100% of mice treated with 10 mg/kg of the agent survived as compared with a 0% survival of control mice treated with saline. Also, the mean survival days were increased and consolidation scores were decreased in treated mice as compared with those of control mice. Two components contained in the agent, extracts from Glycyrrhizae radix and Arctii fructus, expressed antiviral activities in mice infected with influenza virus. However, in vitro growth of influenza virus in MDCK cells or viability of the virus was not affected by these extracts or Gingyo-san. From these results Gingyo-san was shown to be an antiviral agent in mice infected with a lethal amount of a mouse-adopted strain of influenza A₂ virus.
C02	`01`	`X`		`@0 002B05C02C`
C02	`02`	`X`		`@0 235`
C03	`01`	`X`	`FRE`	`@0 Grippe @5 01`
C03	`01`	`X`	`ENG`	`@0 Influenza @5 01`
C03	`01`	`X`	`SPA`	`@0 Gripe @5 01`
C03	`02`	`X`	`FRE`	`@0 Influenzavirus A @2 NW @5 02`
C03	`02`	`X`	`ENG`	`@0 Influenzavirus A @2 NW @5 02`
C03	`02`	`X`	`SPA`	`@0 Influenzavirus A @2 NW @5 02`
C03	`03`	`X`	`FRE`	`@0 Traitement @5 03`
C03	`03`	`X`	`ENG`	`@0 Treatment @5 03`
C03	`03`	`X`	`SPA`	`@0 Tratamiento @5 03`
C03	`04`	`X`	`FRE`	`@0 Médecine chinoise @5 04`
C03	`04`	`X`	`ENG`	`@0 Chinese medicine @5 04`
C03	`04`	`X`	`SPA`	`@0 Medicina china @5 04`
C03	`05`	`X`	`FRE`	`@0 Plante médicinale @5 05`
C03	`05`	`X`	`ENG`	`@0 Medicinal plant @5 05`
C03	`05`	`X`	`SPA`	`@0 Planta medicinal @5 05`
C03	`06`	`X`	`FRE`	`@0 Etude expérimentale @5 06`
C03	`06`	`X`	`ENG`	`@0 Experimental study @5 06`
C03	`06`	`X`	`SPA`	`@0 Estudio experimental @5 06`
C03	`07`	`X`	`FRE`	`@0 Souris @5 07`
C03	`07`	`X`	`ENG`	`@0 Mouse @5 07`
C03	`07`	`X`	`SPA`	`@0 Ratón @5 07`
C03	`08`	`X`	`FRE`	`@0 Animal @5 08`
C03	`08`	`X`	`ENG`	`@0 Animal @5 08`
C03	`08`	`X`	`SPA`	`@0 Animal @5 08`
C07	`01`	`X`	`FRE`	`@0 Virose`
C07	`01`	`X`	`ENG`	`@0 Viral disease`
C07	`01`	`X`	`SPA`	`@0 Virosis`
C07	`02`	`X`	`FRE`	`@0 Infection`
C07	`02`	`X`	`ENG`	`@0 Infection`
C07	`02`	`X`	`SPA`	`@0 Infección`
C07	`03`	`X`	`FRE`	`@0 Orthomyxoviridae @2 NW`
C07	`03`	`X`	`ENG`	`@0 Orthomyxoviridae @2 NW`
C07	`03`	`X`	`SPA`	`@0 Orthomyxoviridae @2 NW`
C07	`04`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`04`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`04`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`05`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`05`	`X`	`ENG`	`@0 Rodentia @2 NS`
C07	`05`	`X`	`SPA`	`@0 Rodentia @2 NS`
C07	`06`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`06`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`06`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`07`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`07`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`07`	`X`	`SPA`	`@0 Vertebrata @2 NS`
N21				`@1 193`

Format Inist (serveur)

NO :	PASCAL 99-0311375 INIST
ET :	Antiviral effect of gingyo-san, a traditional chinese herbal medicine, on influenza A₂ virus infection in mice
AU :	KOBAYASHI (M.); DAVIS (S. M.); UTSUNOMIYA (T.); POLLARD (R. B.); SUZUKI (F.)
AF :	Department of Internal Medicine, The University of Texas Medical Branch/Galveston, Texas 77555/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.)
DT :	Publication en série; Niveau analytique
SO :	The American journal of Chinese medicine : (1979); ISSN 0192-415X; Coden AJCMBA; Etats-Unis; Da. 1999; Vol. 27; No. 1; Pp. 53-62; Bibl. 21 ref.
LA :	Anglais
EA :	Gingyo-san is a crude drug containing extracts from 7 medicinal plants and fermented soybeans in a specific ratio. It has been used clinically in China as a therapeutic agent for the common cold. In the present study, we examined the antiviral effect of this agent on influenza virus infection in mice. Gingyo-san and its components were administered orally to mice 1 day before, then I and 4 days after the inhalation of a mouse-adopted strain of influenza A₂ (H₂N₂) virus. After infection with a 10 LD₅₀ of the virus, 100% of mice treated with 10 mg/kg of the agent survived as compared with a 0% survival of control mice treated with saline. Also, the mean survival days were increased and consolidation scores were decreased in treated mice as compared with those of control mice. Two components contained in the agent, extracts from Glycyrrhizae radix and Arctii fructus, expressed antiviral activities in mice infected with influenza virus. However, in vitro growth of influenza virus in MDCK cells or viability of the virus was not affected by these extracts or Gingyo-san. From these results Gingyo-san was shown to be an antiviral agent in mice infected with a lethal amount of a mouse-adopted strain of influenza A₂ virus.
CC :	002B05C02C; 235
FD :	Grippe; Influenzavirus A; Traitement; Médecine chinoise; Plante médicinale; Etude expérimentale; Souris; Animal
FG :	Virose; Infection; Orthomyxoviridae; Virus; Rodentia; Mammalia; Vertebrata
ED :	Influenza; Influenzavirus A; Treatment; Chinese medicine; Medicinal plant; Experimental study; Mouse; Animal
EG :	Viral disease; Infection; Orthomyxoviridae; Virus; Rodentia; Mammalia; Vertebrata
SD :	Gripe; Influenzavirus A; Tratamiento; Medicina china; Planta medicinal; Estudio experimental; Ratón; Animal
LO :	INIST-16517.354000084223480070
ID :	99-0311375

Links to Exploration step

Pascal:99-0311375

Le document en format XML

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<front><div type="abstract" xml:lang="en">Gingyo-san is a crude drug containing extracts from 7 medicinal plants and fermented soybeans in a specific ratio. It has been used clinically in China as a therapeutic agent for the common cold. In the present study, we examined the antiviral effect of this agent on influenza virus infection in mice. Gingyo-san and its components were administered orally to mice 1 day before, then I and 4 days after the inhalation of a mouse-adopted strain of influenza A<sub>2</sub>
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<fC01 i1="01" l="ENG"><s0>Gingyo-san is a crude drug containing extracts from 7 medicinal plants and fermented soybeans in a specific ratio. It has been used clinically in China as a therapeutic agent for the common cold. In the present study, we examined the antiviral effect of this agent on influenza virus infection in mice. Gingyo-san and its components were administered orally to mice 1 day before, then I and 4 days after the inhalation of a mouse-adopted strain of influenza A<sub>2</sub>
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<s2>NS</s2>
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<s2>NS</s2>
</fC07>
<fN21><s1>193</s1>
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<server><NO>PASCAL 99-0311375 INIST</NO>
<ET>Antiviral effect of gingyo-san, a traditional chinese herbal medicine, on influenza A<sub>2</sub>
 virus infection in mice</ET>
<AU>KOBAYASHI (M.); DAVIS (S. M.); UTSUNOMIYA (T.); POLLARD (R. B.); SUZUKI (F.)</AU>
<AF>Department of Internal Medicine, The University of Texas Medical Branch/Galveston, Texas 77555/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The American journal of Chinese medicine : (1979); ISSN 0192-415X; Coden AJCMBA; Etats-Unis; Da. 1999; Vol. 27; No. 1; Pp. 53-62; Bibl. 21 ref.</SO>
<LA>Anglais</LA>
<EA>Gingyo-san is a crude drug containing extracts from 7 medicinal plants and fermented soybeans in a specific ratio. It has been used clinically in China as a therapeutic agent for the common cold. In the present study, we examined the antiviral effect of this agent on influenza virus infection in mice. Gingyo-san and its components were administered orally to mice 1 day before, then I and 4 days after the inhalation of a mouse-adopted strain of influenza A<sub>2</sub>
 (H<sub>2</sub>
N<sub>2</sub>
) virus. After infection with a 10 LD<sub>50</sub>
 of the virus, 100% of mice treated with 10 mg/kg of the agent survived as compared with a 0% survival of control mice treated with saline. Also, the mean survival days were increased and consolidation scores were decreased in treated mice as compared with those of control mice. Two components contained in the agent, extracts from Glycyrrhizae radix and Arctii fructus, expressed antiviral activities in mice infected with influenza virus. However, in vitro growth of influenza virus in MDCK cells or viability of the virus was not affected by these extracts or Gingyo-san. From these results Gingyo-san was shown to be an antiviral agent in mice infected with a lethal amount of a mouse-adopted strain of influenza A<sub>2</sub>
 virus.</EA>
<CC>002B05C02C; 235</CC>
<FD>Grippe; Influenzavirus A; Traitement; Médecine chinoise; Plante médicinale; Etude expérimentale; Souris; Animal</FD>
<FG>Virose; Infection; Orthomyxoviridae; Virus; Rodentia; Mammalia; Vertebrata</FG>
<ED>Influenza; Influenzavirus A; Treatment; Chinese medicine; Medicinal plant; Experimental study; Mouse; Animal</ED>
<EG>Viral disease; Infection; Orthomyxoviridae; Virus; Rodentia; Mammalia; Vertebrata</EG>
<SD>Gripe; Influenzavirus A; Tratamiento; Medicina china; Planta medicinal; Estudio experimental; Ratón; Animal</SD>
<LO>INIST-16517.354000084223480070</LO>
<ID>99-0311375</ID>
</server>
</inist>
</record>

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Antiviral effect of gingyo-san, a traditional chinese herbal medicine, on influenza A2 virus infection in mice

Antiviral effect of gingyo-san, a traditional chinese herbal medicine, on influenza A2 virus infection in mice

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