Influenza Virus Neuraminidase: Structure and Function
Identifieur interne : 001084 ( Main/Exploration ); précédent : 001083; suivant : 001085Influenza Virus Neuraminidase: Structure and Function
Auteurs : Y. A. Shtyrya ; L. V. Mochalova ; N. V. BovinSource :
- Acta Naturae [ 2075-8251 ] ; 2009.
Abstract
The structure of the influenza virus neuraminidases, the spatial organization of their active site, the mechanism of carbohydrate chains desialylation by neuraminidase, and its role in the influenza virus function at different stages of the viral infectious cycle are considered in this review. Data on the neuraminidase substrate specificity and different approaches in studying the activity of this enzyme are summarized. In addition, data on neuraminidase inhibitors (as antivirals) are provided, along with considerations on the mechanisms of resistance of modern influenza viruses to those antivirals.
Url:
PubMed: 22649600
PubMed Central: 3347517
Affiliations:
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