H2N2V1, Main, Curation, bibRecord, 001084

Influenza Virus Neuraminidase: Structure and Function

Identifieur interne : 001084 ( Main/Curation ); précédent : 001083; suivant : 001085

Influenza Virus Neuraminidase: Structure and Function

Auteurs : Y. A. Shtyrya ; L. V. Mochalova ; N. V. Bovin

Source :

Acta Naturae [ 2075-8251 ] ; 2009.

RBID : PMC:3347517

Abstract

The structure of the influenza virus neuraminidases, the spatial organization of their active site, the mechanism of carbohydrate chains desialylation by neuraminidase, and its role in the influenza virus function at different stages of the viral infectious cycle are considered in this review. Data on the neuraminidase substrate specificity and different approaches in studying the activity of this enzyme are summarized. In addition, data on neuraminidase inhibitors (as antivirals) are provided, along with considerations on the mechanisms of resistance of modern influenza viruses to those antivirals.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347517

PubMed: 22649600
PubMed Central: 3347517

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Y. A. Shtyrya

<affiliation><nlm:aff id="A1">Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS</nlm:aff>
<wicri:noCountry code="subfield">RAS</wicri:noCountry>
</affiliation>

L. V. Mochalova

<affiliation><nlm:aff id="A1">Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS</nlm:aff>
<wicri:noCountry code="subfield">RAS</wicri:noCountry>
</affiliation>

N. V. Bovin

<affiliation><nlm:aff id="A1">Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS</nlm:aff>
<wicri:noCountry code="subfield">RAS</wicri:noCountry>
</affiliation>

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Influenza Virus Neuraminidase: Structure and Function

Influenza Virus Neuraminidase: Structure and Function

Source :

Abstract

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