Influenza Virus Neuraminidase: Structure and Function
Identifieur interne : 000A42 ( Pmc/Checkpoint ); précédent : 000A41; suivant : 000A43Influenza Virus Neuraminidase: Structure and Function
Auteurs : Y. A. Shtyrya ; L. V. Mochalova ; N. V. BovinSource :
- Acta Naturae [ 2075-8251 ] ; 2009.
Abstract
The structure of the influenza virus neuraminidases, the spatial organization of their active site, the mechanism of carbohydrate chains desialylation by neuraminidase, and its role in the influenza virus function at different stages of the viral infectious cycle are considered in this review. Data on the neuraminidase substrate specificity and different approaches in studying the activity of this enzyme are summarized. In addition, data on neuraminidase inhibitors (as antivirals) are provided, along with considerations on the mechanisms of resistance of modern influenza viruses to those antivirals.
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PubMed: 22649600
PubMed Central: 3347517
Affiliations:
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PMC:3347517Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>The structure of the influenza virus neuraminidases, the spatial organization of their active site, the mechanism of carbohydrate chains desialylation by neuraminidase, and its role in the influenza virus function at different stages of the viral infectious cycle are considered in this review. Data on the neuraminidase substrate specificity and different approaches in studying the activity of this enzyme are summarized. In addition, data on neuraminidase inhibitors (as antivirals) are provided, along with considerations on the mechanisms of resistance of modern influenza viruses to those antivirals. </p>
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<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
<subj-group><subject>Molecular Biology</subject>
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<title-group><article-title>Influenza Virus Neuraminidase: Structure and Function</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Shtyrya</surname>
<given-names>Y.A.</given-names>
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<contrib contrib-type="author"><name><surname>Mochalova</surname>
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Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS</aff>
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<pub-date pub-type="ppub"><month>7</month>
<year>2009</year>
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<volume>1</volume>
<issue>2</issue>
<fpage>26</fpage>
<lpage>32</lpage>
<permissions><copyright-statement>Copyright © 2009 Park-media Ltd.</copyright-statement>
<copyright-year>2009</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
</license-p>
</license>
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<abstract><p>The structure of the influenza virus neuraminidases, the spatial organization of their active site, the mechanism of carbohydrate chains desialylation by neuraminidase, and its role in the influenza virus function at different stages of the viral infectious cycle are considered in this review. Data on the neuraminidase substrate specificity and different approaches in studying the activity of this enzyme are summarized. In addition, data on neuraminidase inhibitors (as antivirals) are provided, along with considerations on the mechanisms of resistance of modern influenza viruses to those antivirals. </p>
</abstract>
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