Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets
Identifieur interne : 000F91 ( Main/Curation ); précédent : 000F90; suivant : 000F92Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets
Auteurs : Grace L. Chen [États-Unis] ; Elaine W. Lamirande [États-Unis] ; Chin-Fen Yang [États-Unis] ; HONG JIN [États-Unis] ; George Kemble [États-Unis] ; Kanta Subbarao [États-Unis]Source :
- Journal of virology [ 0022-538X ] ; 2010.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (immunologie), Femelle, Furets, Réactions croisées, Souris, Souris de lignée BALB C, Sous-type H2N2 du virus de la grippe A (croissance et développement), Sous-type H2N2 du virus de la grippe A (immunologie), Tests d'inhibition de l'hémagglutination, Tests de neutralisation, Virus de la grippe A (croissance et développement), Virus de la grippe A (immunologie).
- MESH :
- croissance et développement : Sous-type H2N2 du virus de la grippe A, Virus de la grippe A.
- immunologie : Anticorps neutralisants, Sous-type H2N2 du virus de la grippe A, Virus de la grippe A.
- sang : Anticorps antiviraux.
- Pascal (Inist)
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing (immunology), Antibodies, Viral (blood), Cross Reactions, Female, Ferrets, Hemagglutination Inhibition Tests, Humoral immunity, Immune response, Influenza, Influenza A Virus, H2N2 Subtype (growth & development), Influenza A Virus, H2N2 Subtype (immunology), Influenza A virus (growth & development), Influenza A virus (immunology), Mice, Mice, Inbred BALB C, Mouse, Neutralization Tests, Replication, Subtype.
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , immunology : Antibodies, Neutralizing.
- growth & development : Influenza A Virus, H2N2 Subtype, Influenza A virus.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza A virus.
- Animals, Cross Reactions, Female, Ferrets, Hemagglutination Inhibition Tests, Mice, Mice, Inbred BALB C, Neutralization Tests.
Abstract
H2 influenza viruses have not circulated in humans since 1968, and therefore a large segment of the population would likely be susceptible to infection should H2 influenza viruses reemerge. The development of an H2 pandemic influenza virus vaccine candidate should therefore be considered a priority in pandemic influenza preparedness planning. We selected a group of geographically and temporally diverse wild-type H2 influenza viruses and evaluated the kinetics of replication and compared the ability of these viruses to induce a broadly cross-reactive antibody response in mice and ferrets. In both mice and ferrets, A/Japan/305/1957 (H2N2), A/mallard/NY/1978 (H2N2), and A/swine/MO/2006 (H2N3) elicited the broadest cross-reactive antibody responses against heterologous H2 influenza viruses as measured by hemagglutination inhibition and microneutralization assays. These data suggested that these three viruses may be suitable candidates for development as live attenuated H2 pandemic influenza virus vaccines.
Url:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000019
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :000055
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000021
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000F99
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000719
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000719
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000951
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000198
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000198
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000188
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000533
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000533
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000533
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000E92
Links to Exploration step
Pascal:10-0419682Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets</title>
<author><name sortKey="Chen, Grace L" sort="Chen, Grace L" uniqKey="Chen G" first="Grace L." last="Chen">Grace L. Chen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Chin Fen" sort="Yang, Chin Fen" uniqKey="Yang C" first="Chin-Fen" last="Yang">Chin-Fen Yang</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hong Jin" sort="Hong Jin" uniqKey="Hong Jin" last="Hong Jin">HONG JIN</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0419682</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0419682 INIST</idno>
<idno type="RBID">Pascal:10-0419682</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000019</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000055</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000021</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000021</idno>
<idno type="wicri:doubleKey">0022-538X:2010:Chen G:evaluation:of:replication</idno>
<idno type="wicri:Area/Main/Merge">000F99</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897620</idno>
<idno type="RBID">PMC:2897620</idno>
<idno type="wicri:Area/Pmc/Corpus">000719</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000719</idno>
<idno type="wicri:Area/Pmc/Curation">000719</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000719</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000951</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000951</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:20504935</idno>
<idno type="wicri:Area/PubMed/Corpus">000198</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000198</idno>
<idno type="wicri:Area/PubMed/Curation">000198</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000198</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000188</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000188</idno>
<idno type="wicri:Area/Ncbi/Merge">000533</idno>
<idno type="wicri:Area/Ncbi/Curation">000533</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000533</idno>
<idno type="wicri:doubleKey">0022-538X:2010:Chen G:evaluation:of:replication</idno>
<idno type="wicri:Area/Main/Merge">000E92</idno>
<idno type="wicri:Area/Main/Curation">000F91</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets</title>
<author><name sortKey="Chen, Grace L" sort="Chen, Grace L" uniqKey="Chen G" first="Grace L." last="Chen">Grace L. Chen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Chin Fen" sort="Yang, Chin Fen" uniqKey="Yang C" first="Chin-Fen" last="Yang">Chin-Fen Yang</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hong Jin" sort="Hong Jin" uniqKey="Hong Jin" last="Hong Jin">HONG JIN</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Neutralizing (immunology)</term>
<term>Antibodies, Viral (blood)</term>
<term>Cross Reactions</term>
<term>Female</term>
<term>Ferrets</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humoral immunity</term>
<term>Immune response</term>
<term>Influenza</term>
<term>Influenza A Virus, H2N2 Subtype (growth & development)</term>
<term>Influenza A Virus, H2N2 Subtype (immunology)</term>
<term>Influenza A virus (growth & development)</term>
<term>Influenza A virus (immunology)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mouse</term>
<term>Neutralization Tests</term>
<term>Replication</term>
<term>Subtype</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antiviraux (sang)</term>
<term>Anticorps neutralisants (immunologie)</term>
<term>Femelle</term>
<term>Furets</term>
<term>Réactions croisées</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Sous-type H2N2 du virus de la grippe A (croissance et développement)</term>
<term>Sous-type H2N2 du virus de la grippe A (immunologie)</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Tests de neutralisation</term>
<term>Virus de la grippe A (croissance et développement)</term>
<term>Virus de la grippe A (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Neutralizing</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps neutralisants</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cross Reactions</term>
<term>Female</term>
<term>Ferrets</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Neutralization Tests</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Furets</term>
<term>Réactions croisées</term>
<term>Souris</term>
<term>Réplication</term>
<term>Immunité humorale</term>
<term>Réponse immune</term>
<term>Souris de lignée BALB C</term>
<term>Soustype</term>
<term>Grippe</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Tests de neutralisation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">H2 influenza viruses have not circulated in humans since 1968, and therefore a large segment of the population would likely be susceptible to infection should H2 influenza viruses reemerge. The development of an H2 pandemic influenza virus vaccine candidate should therefore be considered a priority in pandemic influenza preparedness planning. We selected a group of geographically and temporally diverse wild-type H2 influenza viruses and evaluated the kinetics of replication and compared the ability of these viruses to induce a broadly cross-reactive antibody response in mice and ferrets. In both mice and ferrets, A/Japan/305/1957 (H2N2), A/mallard/NY/1978 (H2N2), and A/swine/MO/2006 (H2N3) elicited the broadest cross-reactive antibody responses against heterologous H2 influenza viruses as measured by hemagglutination inhibition and microneutralization assays. These data suggested that these three viruses may be suitable candidates for development as live attenuated H2 pandemic influenza virus vaccines.</div>
</front>
</TEI>
<double idat="0022-538X:2010:Chen G:evaluation:of:replication"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets</title>
<author><name sortKey="Chen, Grace L" sort="Chen, Grace L" uniqKey="Chen G" first="Grace L." last="Chen">Grace L. Chen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Chin Fen" sort="Yang, Chin Fen" uniqKey="Yang C" first="Chin-Fen" last="Yang">Chin-Fen Yang</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hong Jin" sort="Hong Jin" uniqKey="Hong Jin" last="Hong Jin">HONG JIN</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0419682</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0419682 INIST</idno>
<idno type="RBID">Pascal:10-0419682</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000019</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000055</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000021</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000021</idno>
<idno type="wicri:doubleKey">0022-538X:2010:Chen G:evaluation:of:replication</idno>
<idno type="wicri:Area/Main/Merge">000F99</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets</title>
<author><name sortKey="Chen, Grace L" sort="Chen, Grace L" uniqKey="Chen G" first="Grace L." last="Chen">Grace L. Chen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Chin Fen" sort="Yang, Chin Fen" uniqKey="Yang C" first="Chin-Fen" last="Yang">Chin-Fen Yang</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hong Jin" sort="Hong Jin" uniqKey="Hong Jin" last="Hong Jin">HONG JIN</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MedImmune</s1>
<s2>Mountain View, California 94043</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MedImmune</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, NIAID, NIH</s1>
<s2>Bethesda, Maryland 20892</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humoral immunity</term>
<term>Immune response</term>
<term>Influenza</term>
<term>Mouse</term>
<term>Replication</term>
<term>Subtype</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Souris</term>
<term>Réplication</term>
<term>Immunité humorale</term>
<term>Réponse immune</term>
<term>Soustype</term>
<term>Grippe</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">H2 influenza viruses have not circulated in humans since 1968, and therefore a large segment of the population would likely be susceptible to infection should H2 influenza viruses reemerge. The development of an H2 pandemic influenza virus vaccine candidate should therefore be considered a priority in pandemic influenza preparedness planning. We selected a group of geographically and temporally diverse wild-type H2 influenza viruses and evaluated the kinetics of replication and compared the ability of these viruses to induce a broadly cross-reactive antibody response in mice and ferrets. In both mice and ferrets, A/Japan/305/1957 (H2N2), A/mallard/NY/1978 (H2N2), and A/swine/MO/2006 (H2N3) elicited the broadest cross-reactive antibody responses against heterologous H2 influenza viruses as measured by hemagglutination inhibition and microneutralization assays. These data suggested that these three viruses may be suitable candidates for development as live attenuated H2 pandemic influenza virus vaccines.</div>
</front>
</TEI>
</INIST>
<PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets<xref ref-type="fn" rid="fn1">▿</xref>
</title>
<author><name sortKey="Chen, Grace L" sort="Chen, Grace L" uniqKey="Chen G" first="Grace L." last="Chen">Grace L. Chen</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yang, Chin Fen" sort="Yang, Chin Fen" uniqKey="Yang C" first="Chin-Fen" last="Yang">Chin-Fen Yang</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20504935</idno>
<idno type="pmc">2897620</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897620</idno>
<idno type="RBID">PMC:2897620</idno>
<idno type="doi">10.1128/JVI.00511-10</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000719</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000719</idno>
<idno type="wicri:Area/Pmc/Curation">000719</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000719</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000951</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000951</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:20504935</idno>
<idno type="wicri:Area/PubMed/Corpus">000198</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000198</idno>
<idno type="wicri:Area/PubMed/Curation">000198</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000198</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000188</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000188</idno>
<idno type="wicri:Area/Ncbi/Merge">000533</idno>
<idno type="wicri:Area/Ncbi/Curation">000533</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000533</idno>
<idno type="wicri:doubleKey">0022-538X:2010:Chen G:evaluation:of:replication</idno>
<idno type="wicri:Area/Main/Merge">000E92</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets<xref ref-type="fn" rid="fn1">▿</xref>
</title>
<author><name sortKey="Chen, Grace L" sort="Chen, Grace L" uniqKey="Chen G" first="Grace L." last="Chen">Grace L. Chen</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yang, Chin Fen" sort="Yang, Chin Fen" uniqKey="Yang C" first="Chin-Fen" last="Yang">Chin-Fen Yang</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Neutralizing (immunology)</term>
<term>Antibodies, Viral (blood)</term>
<term>Cross Reactions</term>
<term>Female</term>
<term>Ferrets</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Influenza A Virus, H2N2 Subtype (growth & development)</term>
<term>Influenza A Virus, H2N2 Subtype (immunology)</term>
<term>Influenza A virus (growth & development)</term>
<term>Influenza A virus (immunology)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Neutralization Tests</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antiviraux (sang)</term>
<term>Anticorps neutralisants (immunologie)</term>
<term>Femelle</term>
<term>Furets</term>
<term>Réactions croisées</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Sous-type H2N2 du virus de la grippe A (croissance et développement)</term>
<term>Sous-type H2N2 du virus de la grippe A (immunologie)</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Tests de neutralisation</term>
<term>Virus de la grippe A (croissance et développement)</term>
<term>Virus de la grippe A (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Neutralizing</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps neutralisants</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cross Reactions</term>
<term>Female</term>
<term>Ferrets</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Neutralization Tests</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Furets</term>
<term>Réactions croisées</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Tests de neutralisation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>H2 influenza viruses have not circulated in humans since 1968, and therefore a large segment of the population would likely be susceptible to infection should H2 influenza viruses reemerge. The development of an H2 pandemic influenza virus vaccine candidate should therefore be considered a priority in pandemic influenza preparedness planning. We selected a group of geographically and temporally diverse wild-type H2 influenza viruses and evaluated the kinetics of replication and compared the ability of these viruses to induce a broadly cross-reactive antibody response in mice and ferrets. In both mice and ferrets, A/Japan/305/1957 (H2N2), A/mallard/NY/1978 (H2N2), and A/swine/MO/2006 (H2N3) elicited the broadest cross-reactive antibody responses against heterologous H2 influenza viruses as measured by hemagglutination inhibition and microneutralization assays. These data suggested that these three viruses may be suitable candidates for development as live attenuated H2 pandemic influenza virus vaccines.</p>
</div>
</front>
</TEI>
</PMC>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F91 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000F91 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Curation |type= RBID |clé= Pascal:10-0419682 |texte= Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets }}
This area was generated with Dilib version V0.6.33. |