H2N2V1, Ncbi, Curation, bibRecord, 000533

Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets▿

Identifieur interne : 000533 ( Ncbi/Curation ); précédent : 000532; suivant : 000534

Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets▿

Auteurs : Grace L. Chen ; Elaine W. Lamirande ; Chin-Fen Yang ; Hong Jin ; George Kemble ; Kanta Subbarao

Source :

Journal of Virology [ 0022-538X ] ; 2010.

RBID : PMC:2897620

Descripteurs français

KwdFr :
- Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (immunologie), Femelle, Furets, Réactions croisées, Souris, Souris de lignée BALB C, Sous-type H2N2 du virus de la grippe A (croissance et développement), Sous-type H2N2 du virus de la grippe A (immunologie), Tests d'inhibition de l'hémagglutination, Tests de neutralisation, Virus de la grippe A (croissance et développement), Virus de la grippe A (immunologie).
MESH :
- croissance et développement : Sous-type H2N2 du virus de la grippe A, Virus de la grippe A.
- immunologie : Anticorps neutralisants, Sous-type H2N2 du virus de la grippe A, Virus de la grippe A.
- sang : Anticorps antiviraux.
- Animaux, Femelle, Furets, Réactions croisées, Souris, Souris de lignée BALB C, Tests d'inhibition de l'hémagglutination, Tests de neutralisation.

English descriptors

KwdEn :
- Animals, Antibodies, Neutralizing (immunology), Antibodies, Viral (blood), Cross Reactions, Female, Ferrets, Hemagglutination Inhibition Tests, Influenza A Virus, H2N2 Subtype (growth & development), Influenza A Virus, H2N2 Subtype (immunology), Influenza A virus (growth & development), Influenza A virus (immunology), Mice, Mice, Inbred BALB C, Neutralization Tests.
MESH :
- chemical , blood : Antibodies, Viral.
- chemical , immunology : Antibodies, Neutralizing.
- growth & development : Influenza A Virus, H2N2 Subtype, Influenza A virus.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza A virus.
- Animals, Cross Reactions, Female, Ferrets, Hemagglutination Inhibition Tests, Mice, Mice, Inbred BALB C, Neutralization Tests.

Abstract

H2 influenza viruses have not circulated in humans since 1968, and therefore a large segment of the population would likely be susceptible to infection should H2 influenza viruses reemerge. The development of an H2 pandemic influenza virus vaccine candidate should therefore be considered a priority in pandemic influenza preparedness planning. We selected a group of geographically and temporally diverse wild-type H2 influenza viruses and evaluated the kinetics of replication and compared the ability of these viruses to induce a broadly cross-reactive antibody response in mice and ferrets. In both mice and ferrets, A/Japan/305/1957 (H2N2), A/mallard/NY/1978 (H2N2), and A/swine/MO/2006 (H2N3) elicited the broadest cross-reactive antibody responses against heterologous H2 influenza viruses as measured by hemagglutination inhibition and microneutralization assays. These data suggested that these three viruses may be suitable candidates for development as live attenuated H2 pandemic influenza virus vaccines.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897620

DOI: 10.1128/JVI.00511-10
PubMed: 20504935
PubMed Central: 2897620

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PMC:2897620

Le document en format XML

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<term>Ferrets</term>
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<term>Furets</term>
<term>Réactions croisées</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
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<front><div type="abstract" xml:lang="en"><p>H2 influenza viruses have not circulated in humans since 1968, and therefore a large segment of the population would likely be susceptible to infection should H2 influenza viruses reemerge. The development of an H2 pandemic influenza virus vaccine candidate should therefore be considered a priority in pandemic influenza preparedness planning. We selected a group of geographically and temporally diverse wild-type H2 influenza viruses and evaluated the kinetics of replication and compared the ability of these viruses to induce a broadly cross-reactive antibody response in mice and ferrets. In both mice and ferrets, A/Japan/305/1957 (H2N2), A/mallard/NY/1978 (H2N2), and A/swine/MO/2006 (H2N3) elicited the broadest cross-reactive antibody responses against heterologous H2 influenza viruses as measured by hemagglutination inhibition and microneutralization assays. These data suggested that these three viruses may be suitable candidates for development as live attenuated H2 pandemic influenza virus vaccines.</p>
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Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets▿

Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets▿

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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