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Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets

Identifieur interne : 000055 ( PascalFrancis/Curation ); précédent : 000054; suivant : 000056

Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets

Auteurs : Grace L. Chen [États-Unis] ; Elaine W. Lamirande [États-Unis] ; Chin-Fen Yang [États-Unis] ; HONG JIN [États-Unis] ; George Kemble [États-Unis] ; Kanta Subbarao [États-Unis]

Source :

RBID : Pascal:10-0419682

Descripteurs français

English descriptors

Abstract

H2 influenza viruses have not circulated in humans since 1968, and therefore a large segment of the population would likely be susceptible to infection should H2 influenza viruses reemerge. The development of an H2 pandemic influenza virus vaccine candidate should therefore be considered a priority in pandemic influenza preparedness planning. We selected a group of geographically and temporally diverse wild-type H2 influenza viruses and evaluated the kinetics of replication and compared the ability of these viruses to induce a broadly cross-reactive antibody response in mice and ferrets. In both mice and ferrets, A/Japan/305/1957 (H2N2), A/mallard/NY/1978 (H2N2), and A/swine/MO/2006 (H2N3) elicited the broadest cross-reactive antibody responses against heterologous H2 influenza viruses as measured by hemagglutination inhibition and microneutralization assays. These data suggested that these three viruses may be suitable candidates for development as live attenuated H2 pandemic influenza virus vaccines.
pA  
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A03   1    @0 J. virol.
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A08 01  1  ENG  @1 Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets
A11 01  1    @1 CHEN (Grace L.)
A11 02  1    @1 LAMIRANDE (Elaine W.)
A11 03  1    @1 YANG (Chin-Fen)
A11 04  1    @1 HONG JIN
A11 05  1    @1 KEMBLE (George)
A11 06  1    @1 SUBBARAO (Kanta)
A14 01      @1 Laboratory of Infectious Diseases, NIAID, NIH @2 Bethesda, Maryland 20892 @3 USA @Z 1 aut. @Z 2 aut. @Z 6 aut.
A14 02      @1 MedImmune @2 Mountain View, California 94043 @3 USA @Z 3 aut. @Z 4 aut. @Z 5 aut.
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A43 01      @1 INIST @2 13592 @5 354000193821920270
A44       @0 0000 @1 © 2010 INIST-CNRS. All rights reserved.
A45       @0 36 ref.
A47 01  1    @0 10-0419682
A60       @1 P
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C01 01    ENG  @0 H2 influenza viruses have not circulated in humans since 1968, and therefore a large segment of the population would likely be susceptible to infection should H2 influenza viruses reemerge. The development of an H2 pandemic influenza virus vaccine candidate should therefore be considered a priority in pandemic influenza preparedness planning. We selected a group of geographically and temporally diverse wild-type H2 influenza viruses and evaluated the kinetics of replication and compared the ability of these viruses to induce a broadly cross-reactive antibody response in mice and ferrets. In both mice and ferrets, A/Japan/305/1957 (H2N2), A/mallard/NY/1978 (H2N2), and A/swine/MO/2006 (H2N3) elicited the broadest cross-reactive antibody responses against heterologous H2 influenza viruses as measured by hemagglutination inhibition and microneutralization assays. These data suggested that these three viruses may be suitable candidates for development as live attenuated H2 pandemic influenza virus vaccines.
C02 01  X    @0 002A05C10
C03 01  X  FRE  @0 Souris @5 01
C03 01  X  ENG  @0 Mouse @5 01
C03 01  X  SPA  @0 Ratón @5 01
C03 02  X  FRE  @0 Réplication @5 05
C03 02  X  ENG  @0 Replication @5 05
C03 02  X  SPA  @0 Replicación @5 05
C03 03  X  FRE  @0 Immunité humorale @5 06
C03 03  X  ENG  @0 Humoral immunity @5 06
C03 03  X  SPA  @0 Inmunidad humoral @5 06
C03 04  X  FRE  @0 Réponse immune @5 07
C03 04  X  ENG  @0 Immune response @5 07
C03 04  X  SPA  @0 Respuesta inmune @5 07
C03 05  X  FRE  @0 Soustype @5 08
C03 05  X  ENG  @0 Subtype @5 08
C03 05  X  SPA  @0 Subtipo @5 08
C03 06  X  FRE  @0 Grippe @5 14
C03 06  X  ENG  @0 Influenza @5 14
C03 06  X  SPA  @0 Gripe @5 14
C07 01  X  FRE  @0 Rodentia @2 NS
C07 01  X  ENG  @0 Rodentia @2 NS
C07 01  X  SPA  @0 Rodentia @2 NS
C07 02  X  FRE  @0 Mammalia @2 NS
C07 02  X  ENG  @0 Mammalia @2 NS
C07 02  X  SPA  @0 Mammalia @2 NS
C07 03  X  FRE  @0 Vertebrata @2 NS
C07 03  X  ENG  @0 Vertebrata @2 NS
C07 03  X  SPA  @0 Vertebrata @2 NS
C07 04  X  FRE  @0 Virose
C07 04  X  ENG  @0 Viral disease
C07 04  X  SPA  @0 Virosis
C07 05  X  FRE  @0 Infection
C07 05  X  ENG  @0 Infection
C07 05  X  SPA  @0 Infección
N21       @1 277
N44 01      @1 OTO
N82       @1 OTO

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Pascal:10-0419682

Le document en format XML

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<div type="abstract" xml:lang="en">H2 influenza viruses have not circulated in humans since 1968, and therefore a large segment of the population would likely be susceptible to infection should H2 influenza viruses reemerge. The development of an H2 pandemic influenza virus vaccine candidate should therefore be considered a priority in pandemic influenza preparedness planning. We selected a group of geographically and temporally diverse wild-type H2 influenza viruses and evaluated the kinetics of replication and compared the ability of these viruses to induce a broadly cross-reactive antibody response in mice and ferrets. In both mice and ferrets, A/Japan/305/1957 (H2N2), A/mallard/NY/1978 (H2N2), and A/swine/MO/2006 (H2N3) elicited the broadest cross-reactive antibody responses against heterologous H2 influenza viruses as measured by hemagglutination inhibition and microneutralization assays. These data suggested that these three viruses may be suitable candidates for development as live attenuated H2 pandemic influenza virus vaccines.</div>
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