Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers
Identifieur interne : 000523 ( Istex/Curation ); précédent : 000522; suivant : 000524Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers
Auteurs : A. J. Moritz [Autriche, États-Unis] ; C. Kunz [Autriche, États-Unis] ; H. Hofman [Autriche, États-Unis] ; E. Liehl [Autriche, États-Unis] ; P. Reeve [Autriche, États-Unis, Royaume-Uni] ; H. F. Maassab [Autriche, États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1980.
Abstract
A cold-recombinant influenza A virus, CR 22, derived from A/Ann Arbor/6/60 (H2N2) cold-adapted virus and A/Victoria/3/75 (H3N2) wild-type virus, was tested in adult volunteers. CR 22 induced only low-grade clinical reactions in volunteers who had low titers of serum antibodies. Virus could be reisolated from about one-third of the volunteers-but only at low titers. No revertant viruses were found, and there was no evidence for transmission of virus to unvaccinated volunteers housed in close contact with the vaccinees. A high proportion of the volunteers seroconverted, and the mean titers of serum antibody after immunization suggest that a high degree of protection is induced by vaccination with live CR 22 virus.
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DOI: 10.1093/infdis/142.6.857
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Liehl</name><affiliation wicri:level="1"><mods:affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>School of Public Health, University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Reeve, P" sort="Reeve, P" uniqKey="Reeve P" first="P." last="Reeve">P. Reeve</name><affiliation wicri:level="1"><mods:affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>School of Public Health, University of Michigan, Ann Arbor</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Please address requests for reprints to Dr. P. Reeve at his present address: National Institute for Biological Standards and Control, London NW3, England.</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Please address requests for reprints to Dr. P. Reeve at his present address: National Institute for Biological Standards and Control, London NW3</wicri:cityArea></affiliation></author><author><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name><affiliation wicri:level="1"><mods:affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>School of Public Health, University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1980-12">1980</date><biblScope unit="vol">142</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="857">857</biblScope><biblScope unit="page" to="860">860</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">A cold-recombinant influenza A virus, CR 22, derived from A/Ann Arbor/6/60 (H2N2) cold-adapted virus and A/Victoria/3/75 (H3N2) wild-type virus, was tested in adult volunteers. CR 22 induced only low-grade clinical reactions in volunteers who had low titers of serum antibodies. Virus could be reisolated from about one-third of the volunteers-but only at low titers. No revertant viruses were found, and there was no evidence for transmission of virus to unvaccinated volunteers housed in close contact with the vaccinees. A high proportion of the volunteers seroconverted, and the mean titers of serum antibody after immunization suggest that a high degree of protection is induced by vaccination with live CR 22 virus.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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