H2N2V1, Istex, Corpus, bibRecord, 000523

Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers

Identifieur interne : 000523 ( Istex/Corpus ); précédent : 000522; suivant : 000524

Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers

Auteurs : A. J. Moritz ; C. Kunz ; H. Hofman ; E. Liehl ; P. Reeve ; H. F. Maassab

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1980.

RBID : ISTEX:6380C5E3E156D86272BAD256A722DD9E9C508623

Abstract

A cold-recombinant influenza A virus, CR 22, derived from A/Ann Arbor/6/60 (H2N2) cold-adapted virus and A/Victoria/3/75 (H3N2) wild-type virus, was tested in adult volunteers. CR 22 induced only low-grade clinical reactions in volunteers who had low titers of serum antibodies. Virus could be reisolated from about one-third of the volunteers-but only at low titers. No revertant viruses were found, and there was no evidence for transmission of virus to unvaccinated volunteers housed in close contact with the vaccinees. A high proportion of the volunteers seroconverted, and the mean titers of serum antibody after immunization suggest that a high degree of protection is induced by vaccination with live CR 22 virus.

Url:

https://api.istex.fr/ark:/67375/HXZ-BQ8D9QRL-B/fulltext.pdf

DOI: 10.1093/infdis/142.6.857

Links to Exploration step

ISTEX:6380C5E3E156D86272BAD256A722DD9E9C508623

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers</title>
<author><name sortKey="Moritz, A J" sort="Moritz, A J" uniqKey="Moritz A" first="A. J." last="Moritz">A. J. Moritz</name>
<affiliation><mods:affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Kunz, C" sort="Kunz, C" uniqKey="Kunz C" first="C." last="Kunz">C. Kunz</name>
<affiliation><mods:affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Hofman, H" sort="Hofman, H" uniqKey="Hofman H" first="H." last="Hofman">H. Hofman</name>
<affiliation><mods:affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Liehl, E" sort="Liehl, E" uniqKey="Liehl E" first="E." last="Liehl">E. Liehl</name>
<affiliation><mods:affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Reeve, P" sort="Reeve, P" uniqKey="Reeve P" first="P." last="Reeve">P. Reeve</name>
<affiliation><mods:affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>Please address requests for reprints to Dr. P. Reeve at his present address: National Institute for Biological Standards and Control, London NW3, England.</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name>
<affiliation><mods:affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</mods:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:6380C5E3E156D86272BAD256A722DD9E9C508623</idno>
<date when="1980" year="1980">1980</date>
<idno type="doi">10.1093/infdis/142.6.857</idno>
<idno type="url">https://api.istex.fr/ark:/67375/HXZ-BQ8D9QRL-B/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000523</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000523</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers</title>
<author><name sortKey="Moritz, A J" sort="Moritz, A J" uniqKey="Moritz A" first="A. J." last="Moritz">A. J. Moritz</name>
<affiliation><mods:affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Kunz, C" sort="Kunz, C" uniqKey="Kunz C" first="C." last="Kunz">C. Kunz</name>
<affiliation><mods:affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Hofman, H" sort="Hofman, H" uniqKey="Hofman H" first="H." last="Hofman">H. Hofman</name>
<affiliation><mods:affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Liehl, E" sort="Liehl, E" uniqKey="Liehl E" first="E." last="Liehl">E. Liehl</name>
<affiliation><mods:affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Reeve, P" sort="Reeve, P" uniqKey="Reeve P" first="P." last="Reeve">P. Reeve</name>
<affiliation><mods:affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>Please address requests for reprints to Dr. P. Reeve at his present address: National Institute for Biological Standards and Control, London NW3, England.</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name>
<affiliation><mods:affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Journal of Infectious Diseases</title>
<title level="j" type="abbrev">J Infect Dis.</title>
<idno type="ISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
<imprint><publisher>The University of Chicago Press</publisher>
<date when="1980-12">1980</date>
<biblScope unit="vol">142</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="857">857</biblScope>
<biblScope unit="page" to="860">860</biblScope>
</imprint>
<idno type="ISSN">0022-1899</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">A cold-recombinant influenza A virus, CR 22, derived from A/Ann Arbor/6/60 (H2N2) cold-adapted virus and A/Victoria/3/75 (H3N2) wild-type virus, was tested in adult volunteers. CR 22 induced only low-grade clinical reactions in volunteers who had low titers of serum antibodies. Virus could be reisolated from about one-third of the volunteers-but only at low titers. No revertant viruses were found, and there was no evidence for transmission of virus to unvaccinated volunteers housed in close contact with the vaccinees. A high proportion of the volunteers seroconverted, and the mean titers of serum antibody after immunization suggest that a high degree of protection is induced by vaccination with live CR 22 virus.</div>
</front>
</TEI>
<istex><corpusName>oup</corpusName>
<keywords><teeft><json:string>recombinant</json:string>
<json:string>placebo</json:string>
<json:string>inoculated</json:string>
<json:string>serologic</json:string>
<json:string>reeve</json:string>
<json:string>attenuated</json:string>
<json:string>infective</json:string>
<json:string>vaccine</json:string>
<json:string>seroconverted</json:string>
<json:string>sore throat</json:string>
<json:string>maassab</json:string>
<json:string>mild rhinitis</json:string>
<json:string>student volunteer</json:string>
<json:string>rhinitis</json:string>
<json:string>systemic reaction</json:string>
<json:string>reisolated</json:string>
<json:string>titer</json:string>
<json:string>up respiratory tract symptom</json:string>
<json:string>arbor strain</json:string>
<json:string>serum antibody</json:string>
<json:string>mild headache</json:string>
<json:string>serum antibody titer</json:string>
<json:string>influenza</json:string>
<json:string>volunteer</json:string>
<json:string>virus</json:string>
<json:string>placebo material</json:string>
<json:string>fertile chicken egg</json:string>
<json:string>dose response</json:string>
<json:string>adult volunteer</json:string>
<json:string>body temperature</json:string>
<json:string>minimal essential medium</json:string>
<json:string>sandoz forschungsinstitut</json:string>
<json:string>clinical response</json:string>
<json:string>clinical trial</json:string>
<json:string>reactogenicityj serologic response</json:string>
<json:string>virus vaccine</json:string>
<json:string>clinical study</json:string>
<json:string>postinoculation titer</json:string>
<json:string>oral temperature</json:string>
<json:string>national institute</json:string>
<json:string>muscular pain</json:string>
<json:string>anyone occasion</json:string>
<json:string>consecutive day</json:string>
<json:string>runny nose</json:string>
<json:string>same criterion</json:string>
<json:string>revertant virus</json:string>
<json:string>infectious disease</json:string>
<json:string>allantoic fluid</json:string>
<json:string>stuffy nose</json:string>
<json:string>placebo group</json:string>
<json:string>serologic response</json:string>
<json:string>highest dose</json:string>
<json:string>reisolated virus</json:string>
<json:string>human infective dose</json:string>
<json:string>arbor</json:string>
<json:string>vaccination</json:string>
<json:string>stuffy</json:string>
</teeft>
</keywords>
<author><json:item><name>A. J. Moritz</name>
<affiliations><json:string>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</json:string>
<json:string>School of Public Health, University of Michigan, Ann Arbor, Michigan</json:string>
</affiliations>
</json:item>
<json:item><name>C. Kunz</name>
<affiliations><json:string>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</json:string>
<json:string>School of Public Health, University of Michigan, Ann Arbor, Michigan</json:string>
</affiliations>
</json:item>
<json:item><name>H. Hofman</name>
<affiliations><json:string>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</json:string>
<json:string>School of Public Health, University of Michigan, Ann Arbor, Michigan</json:string>
</affiliations>
</json:item>
<json:item><name>E. Liehl</name>
<affiliations><json:string>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</json:string>
<json:string>School of Public Health, University of Michigan, Ann Arbor, Michigan</json:string>
</affiliations>
</json:item>
<json:item><name>Dr. P. Reeve</name>
<affiliations><json:string>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</json:string>
<json:string>School of Public Health, University of Michigan, Ann Arbor, Michigan</json:string>
<json:string>Please address requests for reprints to Dr. P. Reeve at his present address: National Institute for Biological Standards and Control, London NW3, England.</json:string>
</affiliations>
</json:item>
<json:item><name>H. F. Maassab</name>
<affiliations><json:string>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</json:string>
<json:string>School of Public Health, University of Michigan, Ann Arbor, Michigan</json:string>
</affiliations>
</json:item>
</author>
<arkIstex>ark:/67375/HXZ-BQ8D9QRL-B</arkIstex>
<language><json:string>unknown</json:string>
</language>
<originalGenre><json:string>research-article</json:string>
</originalGenre>
<abstract>A cold-recombinant influenza A virus, CR 22, derived from A/Ann Arbor/6/60 (H2N2) cold-adapted virus and A/Victoria/3/75 (H3N2) wild-type virus, was tested in adult volunteers. CR 22 induced only low-grade clinical reactions in volunteers who had low titers of serum antibodies. Virus could be reisolated from about one-third of the volunteers-but only at low titers. No revertant viruses were found, and there was no evidence for transmission of virus to unvaccinated volunteers housed in close contact with the vaccinees. A high proportion of the volunteers seroconverted, and the mean titers of serum antibody after immunization suggest that a high degree of protection is induced by vaccination with live CR 22 virus.</abstract>
<qualityIndicators><score>4.027</score>
<pdfWordCount>2040</pdfWordCount>
<pdfCharCount>13251</pdfCharCount>
<pdfVersion>1.4</pdfVersion>
<pdfPageCount>4</pdfPageCount>
<pdfPageSize>612 x 768.96 pts</pdfPageSize>
<pdfWordsPerPage>510</pdfWordsPerPage>
<pdfText>true</pdfText>
<refBibsNative>false</refBibsNative>
<abstractWordCount>110</abstractWordCount>
<abstractCharCount>721</abstractCharCount>
<keywordCount>0</keywordCount>
</qualityIndicators>
<title>Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers</title>
<pmid><json:string>7462697</json:string>
</pmid>
<genre><json:string>research-article</json:string>
</genre>
<host><title>Journal of Infectious Diseases</title>
<language><json:string>unknown</json:string>
</language>
<issn><json:string>0022-1899</json:string>
</issn>
<eissn><json:string>1537-6613</json:string>
</eissn>
<publisherId><json:string>jid</json:string>
</publisherId>
<volume>142</volume>
<issue>6</issue>
<pages><first>857</first>
<last>860</last>
</pages>
<genre><json:string>journal</json:string>
</genre>
</host>
<namedEntities><unitex><date><json:string>May, June, and October 1977</json:string>
<json:string>1980</json:string>
</date>
<geogName></geogName>
<orgName><json:string>University of Michigan</json:string>
<json:string>National Institute of Allergy and Infectious Diseases</json:string>
<json:string>Ethical Committee of the Sandoz Forschungsinstitut</json:string>
<json:string>Difco Laboratories</json:string>
<json:string>National Institute for Biological Standards and Control</json:string>
<json:string>World Health Organization</json:string>
</orgName>
<orgName_funder></orgName_funder>
<orgName_provider></orgName_provider>
<persName><json:string>Maassab</json:string>
<json:string>Hong Kong</json:string>
<json:string>H. Hofman</json:string>
<json:string>P. Reeve</json:string>
<json:string>C. Kunz</json:string>
<json:string>Ann Arbor</json:string>
<json:string>H. F. Maassab</json:string>
<json:string>E. Liehl</json:string>
</persName>
<placeName><json:string>Austria</json:string>
<json:string>Port Chalmers</json:string>
<json:string>Helsinki</json:string>
<json:string>Vienna</json:string>
<json:string>United Kingdom</json:string>
</placeName>
<ref_url></ref_url>
<ref_bibl><json:string>[6]</json:string>
<json:string>[1]</json:string>
<json:string>[3]</json:string>
<json:string>[4, 5]</json:string>
<json:string>Moritz et al.</json:string>
<json:string>[2]</json:string>
</ref_bibl>
<bibl></bibl>
</unitex>
</namedEntities>
<ark><json:string>ark:/67375/HXZ-BQ8D9QRL-B</json:string>
</ark>
<categories><wos><json:string>1 - science</json:string>
<json:string>2 - microbiology</json:string>
<json:string>2 - infectious diseases</json:string>
<json:string>2 - immunology</json:string>
</wos>
<scienceMetrix><json:string>1 - health sciences</json:string>
<json:string>2 - biomedical research</json:string>
<json:string>3 - microbiology</json:string>
</scienceMetrix>
<scopus><json:string>1 - Health Sciences</json:string>
<json:string>2 - Medicine</json:string>
<json:string>3 - Infectious Diseases</json:string>
<json:string>1 - Health Sciences</json:string>
<json:string>2 - Medicine</json:string>
<json:string>3 - Immunology and Allergy</json:string>
</scopus>
<inist><json:string>1 - sciences appliquees, technologies et medecines</json:string>
<json:string>2 - sciences biologiques et medicales</json:string>
<json:string>3 - sciences medicales</json:string>
</inist>
</categories>
<publicationDate>1980</publicationDate>
<copyrightDate>1980</copyrightDate>
<doi><json:string>10.1093/infdis/142.6.857</json:string>
</doi>
<id>6380C5E3E156D86272BAD256A722DD9E9C508623</id>
<score>1</score>
<fulltext><json:item><extension>pdf</extension>
<original>true</original>
<mimetype>application/pdf</mimetype>
<uri>https://api.istex.fr/ark:/67375/HXZ-BQ8D9QRL-B/fulltext.pdf</uri>
</json:item>
<json:item><extension>zip</extension>
<original>false</original>
<mimetype>application/zip</mimetype>
<uri>https://api.istex.fr/ark:/67375/HXZ-BQ8D9QRL-B/bundle.zip</uri>
</json:item>
<istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/HXZ-BQ8D9QRL-B/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers</title>
<respStmt><resp>Références bibliographiques récupérées via GROBID</resp>
<name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name>
</respStmt>
</titleStmt>
<publicationStmt><authority>ISTEX</authority>
<publisher>The University of Chicago Press</publisher>
<availability><licence>© 1980 by The University of Chicago</licence>
</availability>
<date type="Copyright" when="1980">1980</date>
<date when="1980-12">1980</date>
</publicationStmt>
<notesStmt><note type="content-type" source="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note>
<note type="publication-type" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note>
</notesStmt>
<sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers</title>
<author xml:id="author-0000"><persName><surname>Moritz</surname>
<forename type="first">A. J.</forename>
</persName>
<affiliation><orgName type="institution">Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien</orgName>
<address><addrLine>Vienna, Austria</addrLine>
</address>
</affiliation>
<affiliation><orgName type="department">School of Public Health</orgName>
<orgName type="institution">University of Michigan</orgName>
<address><addrLine>Ann Arbor, Michigan</addrLine>
</address>
</affiliation>
</author>
<author xml:id="author-0001"><persName><surname>Kunz</surname>
<forename type="first">C.</forename>
</persName>
<affiliation><orgName type="institution">Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien</orgName>
<address><addrLine>Vienna, Austria</addrLine>
</address>
</affiliation>
<affiliation><orgName type="department">School of Public Health</orgName>
<orgName type="institution">University of Michigan</orgName>
<address><addrLine>Ann Arbor, Michigan</addrLine>
</address>
</affiliation>
</author>
<author xml:id="author-0002"><persName><surname>Hofman</surname>
<forename type="first">H.</forename>
</persName>
<affiliation><orgName type="institution">Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien</orgName>
<address><addrLine>Vienna, Austria</addrLine>
</address>
</affiliation>
<affiliation><orgName type="department">School of Public Health</orgName>
<orgName type="institution">University of Michigan</orgName>
<address><addrLine>Ann Arbor, Michigan</addrLine>
</address>
</affiliation>
</author>
<author xml:id="author-0003"><persName><surname>Liehl</surname>
<forename type="first">E.</forename>
</persName>
<affiliation><orgName type="institution">Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien</orgName>
<address><addrLine>Vienna, Austria</addrLine>
</address>
</affiliation>
<affiliation><orgName type="department">School of Public Health</orgName>
<orgName type="institution">University of Michigan</orgName>
<address><addrLine>Ann Arbor, Michigan</addrLine>
</address>
</affiliation>
</author>
<author xml:id="author-0004" role="corresp"><persName><surname>Reeve</surname>
<forename type="first">P.</forename>
<roleName>Dr.</roleName>
</persName>
<affiliation><orgName type="institution">Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien</orgName>
<address><addrLine>Vienna, Austria</addrLine>
</address>
</affiliation>
<affiliation><orgName type="department">School of Public Health</orgName>
<orgName type="institution">University of Michigan</orgName>
<address><addrLine>Ann Arbor, Michigan</addrLine>
</address>
</affiliation>
<affiliation role="corresp">Please address requests for reprints to Dr. P. Reeve at his present address: National Institute for Biological Standards and Control, London NW3, England.</affiliation>
</author>
<author xml:id="author-0005"><persName><surname>Maassab</surname>
<forename type="first">H. F.</forename>
</persName>
<affiliation><orgName type="institution">Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien</orgName>
<address><addrLine>Vienna, Austria</addrLine>
</address>
</affiliation>
<affiliation><orgName type="department">School of Public Health</orgName>
<orgName type="institution">University of Michigan</orgName>
<address><addrLine>Ann Arbor, Michigan</addrLine>
</address>
</affiliation>
</author>
<idno type="istex">6380C5E3E156D86272BAD256A722DD9E9C508623</idno>
<idno type="ark">ark:/67375/HXZ-BQ8D9QRL-B</idno>
<idno type="DOI">10.1093/infdis/142.6.857</idno>
</analytic>
<monogr><title level="j" type="main">Journal of Infectious Diseases</title>
<title level="j" type="abbrev">J Infect Dis.</title>
<idno type="hwp">jinfdis</idno>
<idno type="publisher-id">jid</idno>
<idno type="pISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
<imprint><publisher>The University of Chicago Press</publisher>
<date when="1980-12">1980</date>
<biblScope unit="vol">142</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="857">857</biblScope>
<biblScope unit="page" to="860">860</biblScope>
</imprint>
</monogr>
</biblStruct>
</sourceDesc>
</fileDesc>
<encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef>
<appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-09"><label>pub2TEI-ISTEX</label>
<desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
                        <ref target="http://www.tei-c.org/">We use TEI</ref>
</desc>
</application>
</appInfo>
</encodingDesc>
<profileDesc><abstract><p>A cold-recombinant influenza A virus, CR 22, derived from A/Ann Arbor/6/60 (H2N2) cold-adapted virus and A/Victoria/3/75 (H3N2) wild-type virus, was tested in adult volunteers. CR 22 induced only low-grade clinical reactions in volunteers who had low titers of serum antibodies. Virus could be reisolated from about one-third of the volunteers-but only at low titers. No revertant viruses were found, and there was no evidence for transmission of virus to unvaccinated volunteers housed in close contact with the vaccinees. A high proportion of the volunteers seroconverted, and the mean titers of serum antibody after immunization suggest that a high degree of protection is induced by vaccination with live CR 22 virus.</p>
</abstract>
<textClass ana="subject"><keywords scheme="heading"><term>Immunoprophylaxis</term>
</keywords>
</textClass>
<langUsage><language ident="EN"></language>
</langUsage>
</profileDesc>
<revisionDesc><change when="2019-12-09" who="#istex" xml:id="pub2tei">formatting</change>
<change xml:id="refBibs-istex" who="#ISTEX-API" when="2019-12-10">References added</change>
</revisionDesc>
</teiHeader>
</istex:fulltextTEI>
<json:item><extension>txt</extension>
<original>false</original>
<mimetype>text/plain</mimetype>
<uri>https://api.istex.fr/ark:/67375/HXZ-BQ8D9QRL-B/fulltext.txt</uri>
</json:item>
</fulltext>
<metadata><istex:metadataXml wicri:clean="corpus oup, element #text not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0"</istex:xmlDeclaration>
<istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType>
<istex:document><article article-type="research-article">

<front>

<journal-meta>

<journal-id journal-id-type="hwp">jinfdis</journal-id>

<journal-id journal-id-type="publisher-id">jid</journal-id>

<journal-title>Journal of Infectious Diseases</journal-title>

<abbrev-journal-title>J Infect Dis.</abbrev-journal-title>

<issn pub-type="ppub">0022-1899</issn>

<issn pub-type="epub">1537-6613</issn>

<publisher>

<publisher-name>The University of Chicago Press</publisher-name>

</publisher>

</journal-meta>

<article-meta>

<article-id pub-id-type="doi">10.1093/infdis/142.6.857</article-id>

<article-categories>

<subj-group subj-group-type="heading">

<subject>Immunoprophylaxis</subject>

</subj-group>

</article-categories>

<title-group>

<article-title>Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers</article-title>

</title-group>

<contrib-group>

<contrib contrib-type="author">

<name>

<surname>Moritz</surname>

<given-names>A. J.</given-names>

</name>

<xref ref-type="aff" rid="A1"></xref>

<xref ref-type="aff" rid="A2"></xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Kunz</surname>

<given-names>C.</given-names>

</name>

<xref ref-type="aff" rid="A1"></xref>

<xref ref-type="aff" rid="A2"></xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Hofman</surname>

<given-names>H.</given-names>

</name>

<xref ref-type="aff" rid="A1"></xref>

<xref ref-type="aff" rid="A2"></xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Liehl</surname>

<given-names>E.</given-names>

</name>

<xref ref-type="aff" rid="A1"></xref>

<xref ref-type="aff" rid="A2"></xref>

</contrib>

<contrib contrib-type="author" corresp="yes">

<name>

<surname>Reeve</surname>

<given-names>P.</given-names>

<prefix>Dr.</prefix>

</name>

<xref ref-type="aff" rid="A1"></xref>

<xref ref-type="aff" rid="A2"></xref>

<xref ref-type="corresp" rid="cor1"></xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Maassab</surname>

<given-names>H. F.</given-names>

</name>

<xref ref-type="aff" rid="A1"></xref>

<xref ref-type="aff" rid="A2"></xref>

</contrib>

<aff id="A1">

<institution>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien</institution>
, <addr-line>Vienna, Austria</addr-line>

</aff>

<aff id="A2">

<institution>School of Public Health, University of Michigan</institution>
, <addr-line>Ann Arbor, Michigan</addr-line>

</aff>

</contrib-group>

<author-notes>

<corresp id="cor1">Please address requests for reprints to Dr. P. Reeve at his present address: National Institute for Biological Standards and Control, London NW3, England.</corresp>

</author-notes>

<pub-date pub-type="ppub">

<month>12</month>

<year>1980</year>

</pub-date>

<volume>142</volume>

<issue>6</issue>

<fpage>857</fpage>

<lpage>860</lpage>

<history>

<date date-type="received">

<day>30</day>

<month>4</month>

<year>1979</year>

</date>

<date date-type="rev-recd">

<day>15</day>

<month>7</month>

<year>1980</year>

</date>

</history>

<copyright-statement>© 1980 by The University of Chicago</copyright-statement>

<copyright-year>1980</copyright-year>

<abstract>

<p>A cold-recombinant influenza A virus, CR 22, derived from A/Ann Arbor/6/60 (H2N2) cold-adapted virus and A/Victoria/3/75 (H3N2) wild-type virus, was tested in adult volunteers. CR 22 induced only low-grade clinical reactions in volunteers who had low titers of serum antibodies. Virus could be reisolated from about one-third of the volunteers-but only at low titers. No revertant viruses were found, and there was no evidence for transmission of virus to unvaccinated volunteers housed in close contact with the vaccinees. A high proportion of the volunteers seroconverted, and the mean titers of serum antibody after immunization suggest that a high degree of protection is induced by vaccination with live CR 22 virus.</p>

</abstract>

</article-meta>

</front>

</article>

</istex:document>
</istex:metadataXml>
<mods version="3.6"><titleInfo><title>Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA"><title>Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers</title>
</titleInfo>
<name type="personal"><namePart type="given">A. J.</namePart>
<namePart type="family">Moritz</namePart>
<affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</affiliation>
<affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C.</namePart>
<namePart type="family">Kunz</namePart>
<affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</affiliation>
<affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H.</namePart>
<namePart type="family">Hofman</namePart>
<affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</affiliation>
<affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E.</namePart>
<namePart type="family">Liehl</namePart>
<affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</affiliation>
<affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal" displayLabel="corresp"><namePart type="termsOfAddress">Dr.</namePart>
<namePart type="given">P.</namePart>
<namePart type="family">Reeve</namePart>
<affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</affiliation>
<affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</affiliation>
<affiliation>Please address requests for reprints to Dr. P. Reeve at his present address: National Institute for Biological Standards and Control, London NW3, England.</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H. F.</namePart>
<namePart type="family">Maassab</namePart>
<affiliation>Sandoz Forschungsinstitut and the Institut für Virologie der Universität Vien, Vienna, Austria</affiliation>
<affiliation>School of Public Health, University of Michigan, Ann Arbor, Michigan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre>
<originInfo><publisher>The University of Chicago Press</publisher>
<dateIssued encoding="w3cdtf">1980-12</dateIssued>
<copyrightDate encoding="w3cdtf">1980</copyrightDate>
</originInfo>
<abstract>A cold-recombinant influenza A virus, CR 22, derived from A/Ann Arbor/6/60 (H2N2) cold-adapted virus and A/Victoria/3/75 (H3N2) wild-type virus, was tested in adult volunteers. CR 22 induced only low-grade clinical reactions in volunteers who had low titers of serum antibodies. Virus could be reisolated from about one-third of the volunteers-but only at low titers. No revertant viruses were found, and there was no evidence for transmission of virus to unvaccinated volunteers housed in close contact with the vaccinees. A high proportion of the volunteers seroconverted, and the mean titers of serum antibody after immunization suggest that a high degree of protection is induced by vaccination with live CR 22 virus.</abstract>
<note type="author-notes">Please address requests for reprints to Dr. P. Reeve at his present address: National Institute for Biological Standards and Control, London NW3, England.</note>
<relatedItem type="host"><titleInfo><title>Journal of Infectious Diseases</title>
</titleInfo>
<titleInfo type="abbreviated"><title>J Infect Dis.</title>
</titleInfo>
<genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre>
<identifier type="ISSN">0022-1899</identifier>
<identifier type="eISSN">1537-6613</identifier>
<identifier type="PublisherID">jid</identifier>
<identifier type="PublisherID-hwp">jinfdis</identifier>
<part><date>1980</date>
<detail type="volume"><caption>vol.</caption>
<number>142</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>6</number>
</detail>
<extent unit="pages"><start>857</start>
<end>860</end>
</extent>
</part>
</relatedItem>
<identifier type="istex">6380C5E3E156D86272BAD256A722DD9E9C508623</identifier>
<identifier type="ark">ark:/67375/HXZ-BQ8D9QRL-B</identifier>
<identifier type="DOI">10.1093/infdis/142.6.857</identifier>
<accessCondition type="use and reproduction" contentType="copyright">© 1980 by The University of Chicago</accessCondition>
<recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-GTWS0RDP-M">oup</recordContentSource>
<recordOrigin>Converted from  (version 1.2.0) to MODS version 3.6.</recordOrigin>
<recordCreationDate encoding="w3cdtf">2019-12-09</recordCreationDate>
</recordInfo>
</mods>
<json:item><extension>json</extension>
<original>false</original>
<mimetype>application/json</mimetype>
<uri>https://api.istex.fr/ark:/67375/HXZ-BQ8D9QRL-B/record.json</uri>
</json:item>
</metadata>
<covers><json:item><extension>tiff</extension>
<original>true</original>
<mimetype>image/tiff</mimetype>
<uri>https://api.istex.fr/document/6380C5E3E156D86272BAD256A722DD9E9C508623/covers/tiff</uri>
</json:item>
</covers>
<annexes><json:item><extension>pdf</extension>
<original>true</original>
<mimetype>application/pdf</mimetype>
<uri>https://api.istex.fr/ark:/67375/HXZ-BQ8D9QRL-B/annexes.pdf</uri>
</json:item>
</annexes>
<serie></serie>
</istex>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Istex/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000523 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000523 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Istex
   |étape=   Corpus
   |type=    RBID
   |clé=     ISTEX:6380C5E3E156D86272BAD256A722DD9E9C508623
   |texte=   Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration H2N2

Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers

Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri