Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses
Identifieur interne : 000B69 ( Istex/Corpus ); précédent : 000B68; suivant : 000B70Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses
Auteurs : Jayanta Haldar ; Jianzhu Chen ; Terrence M. Tumpey ; Larisa V. Gubareva ; Alexander M. KlibanovSource :
- Biotechnology Letters [ 0141-5492 ] ; 2008-03-01.
English descriptors
- KwdEn :
Abstract
Abstract: Glass slides painted with the hydrophobic long-chained polycation N,N-dodecyl,methyl-polyethylenimine (N,N-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their neuraminidase mutants resistant to currently used anti-influenza drugs.
Url:
DOI: 10.1007/s10529-007-9565-5
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ISTEX:52EEDCEBB0D2BE8E216764EECF9A70EA53DEAB5DLe document en format XML
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Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Jayanta</GivenName><FamilyName>Haldar</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>Jianzhu</GivenName><FamilyName>Chen</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>Terrence</GivenName><GivenName>M.</GivenName><FamilyName>Tumpey</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>Larisa</GivenName><GivenName>V.</GivenName><FamilyName>Gubareva</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Alexander</GivenName><GivenName>M.</GivenName><FamilyName>Klibanov</FamilyName></AuthorName><Contact><Email>klibanov@mit.edu</Email></Contact></Author><Affiliation ID="Aff1"><OrgDivision>Departments of Chemistry and Biological Engineering</OrgDivision><OrgName>Massachusetts Institute of Technology</OrgName><OrgAddress><City>Cambridge</City><State>MA</State><Postcode>02139</Postcode><Country Code="US">USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Center for Cancer Research and Department of Biology</OrgDivision><OrgName>Massachusetts Institute of Technology</OrgName><OrgAddress><City>Cambridge</City><State>MA</State><Postcode>02139</Postcode><Country Code="US">USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgName>Centers for Disease Control and Prevention</OrgName><OrgAddress><City>Atlanta</City><State>GA</State><Postcode>30333</Postcode><Country Code="US">USA</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En" OutputMedium="All"><Heading>Abstract</Heading><Para>Glass slides painted with the hydrophobic long-chained polycation <Emphasis Type="Italic">N</Emphasis>,<Emphasis Type="Italic">N</Emphasis>-dodecyl,methyl-polyethylenimine (<Emphasis Type="Italic">N</Emphasis>,<Emphasis Type="Italic">N</Emphasis>-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their neuraminidase mutants resistant to currently used anti-influenza drugs.</Para></Abstract><KeywordGroup Language="En" OutputMedium="All"><Heading>Keywords</Heading><Keyword>Antiviral</Keyword><Keyword>Polyethylenimine</Keyword><Keyword>Quaternary amines</Keyword><Keyword>Relenza</Keyword><Keyword>Tamiflu</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses</title></titleInfo><name type="personal"><namePart type="given">Jayanta</namePart><namePart type="family">Haldar</namePart><affiliation>Departments of Chemistry and Biological Engineering, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jianzhu</namePart><namePart 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