Characterization of Cells Infiltrating the Lungs of X‐Irradiated and Nude Mice after Influenza Virus Infection
Identifieur interne : 000185 ( Istex/Corpus ); précédent : 000184; suivant : 000186Characterization of Cells Infiltrating the Lungs of X‐Irradiated and Nude Mice after Influenza Virus Infection
Auteurs : Emiko Shimomura ; Fujio Suzuki ; Nakao IshidaSource :
- Microbiology and Immunology [ 0385-5600 ] ; 1982-02.
English descriptors
- Teeft :
- Antilymphocyte serum, Athymic, Cell suspensions, Consolidation score, Cytotoxic, Deficient mice, Definite delay, Epithelial cells, Euthymic mice, First group, Haired littermates, Infection, Influenza, Influenza infection, Influenza virus, Influenza virus infection, Killer cells, Kumamoto strain, Lung consolidation, Lung lesions, Lung tissues, Lymphocyte, Lymphocyte suspension, Lymphoid, Lymphoid cells, Mast cells, Mice inoculated, Morphological classification, Mouse, Mouse lungs, Nonirradiated, Nonirradiated mice, Normal groups, Normal mice, Nude mice, Second group, Small lymphoid cells, Small round cells, Spontaneous release, Survival days, Survival period, Target cells, Third group, Unidentifiable cells, Virus infection.
Abstract
After X‐irradiated and nonirradiated mice (C3H/He) as well as athymic nude mice and haired littermates (BALB/c) were infected with influenza A virus (Kumamoto strain, H2N2), they were examined for survival period, the development of consolidation in the lungs and the characteristics of the cells infiltrating the lung tissues. In two different T‐cell deficient groups, there was a definite delay in the development of consolidation compared with their respective controls and this was reflected in prolonged survival periods: 5 days longer for irradiated mice and 6 days longer for nude mice. In both T‐cell deficient and normal groups, about 70% of the cells obtained from consolidated lung tissues after virus infection were found to be small lymphoid cells and there were no morphological differences between the T‐cell deficient and normal groups. None of these small lymphoid cells from the peripheral blood or the spleens of T‐cell deficient mice responded to concanavalin A. In the lungs of both X‐irradiated mice and nude mice, however, a definite increase in cells having natural killer activity was found at the late stages of the influenza infection, suggesting their participation in the development of consolidation.
Url:
DOI: 10.1111/j.1348-0421.1982.tb00162.x
Links to Exploration step
ISTEX:5702CB7AAEDD02DCCB28A064FB30F0F2F085CA00Le document en format XML
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tissues</term><term>Lymphocyte</term><term>Lymphocyte suspension</term><term>Lymphoid</term><term>Lymphoid cells</term><term>Mast cells</term><term>Mice inoculated</term><term>Morphological classification</term><term>Mouse</term><term>Mouse lungs</term><term>Nonirradiated</term><term>Nonirradiated mice</term><term>Normal groups</term><term>Normal mice</term><term>Nude mice</term><term>Second group</term><term>Small lymphoid cells</term><term>Small round cells</term><term>Spontaneous release</term><term>Survival days</term><term>Survival period</term><term>Target cells</term><term>Third group</term><term>Unidentifiable cells</term><term>Virus infection</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">After X‐irradiated and nonirradiated mice (C3H/He) as well as athymic nude mice and haired littermates (BALB/c) were infected with influenza A virus (Kumamoto strain, H2N2), they were examined for survival period, the development of consolidation in the 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In two different T‐cell deficient groups, there was a definite delay in the development of consolidation compared with their respective controls and this was reflected in prolonged survival periods: 5 days longer for irradiated mice and 6 days longer for nude mice. In both T‐cell deficient and normal groups, about 70% of the cells obtained from consolidated lung tissues after virus infection were found to be small lymphoid cells and there were no morphological differences between the T‐cell deficient and normal groups. None of these small lymphoid cells from the peripheral blood or the spleens of T‐cell deficient mice responded to concanavalin A. 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In the lungs of both X‐irradiated mice and nude mice, however, a definite increase in cells having natural killer activity was found at the late stages of the influenza infection, suggesting their participation in the development of consolidation.</p></abstract><textClass><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-3Q9BCF9B-Q/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en" xml:id="MIM00162"><header><publicationMeta level="product"><doi origin="wiley">10.1111/(ISSN)1348-0421</doi><issn type="print">0385-5600</issn><issn type="electronic">1348-0421</issn><idGroup><id type="product" value="MIM"></id></idGroup><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="15"></count></countGroup><titleGroup><title type="main" sort="MICROBIOLOGY AND IMMUNOLOGY">Microbiology and Immunology</title><title type="short">Microbiology and Immunology</title></titleGroup></publicationMeta><publicationMeta level="part" position="20"><doi origin="wiley">10.1111/mim.1982.26.issue-2</doi><copyright ownership="publisher">© owned by Center for Academic Publications Japan (Publisher)</copyright><numberingGroup><numbering type="journalVolume" number="26">26</numbering><numbering type="journalIssue">2</numbering></numberingGroup><coverDate startDate="1982-02">February 1982</coverDate></publicationMeta><publicationMeta level="unit" position="50" type="article" status="forIssue"><doi origin="wiley">10.1111/j.1348-0421.1982.tb00162.x</doi><idGroup><id type="unit" value="MIM00162"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="thirdParty">© owned by Center for Academic Publications Japan (Publisher)</copyright><eventGroup><event type="manuscriptReceived" date="1981-08-08"></event><event type="manuscriptAccepted" date="1981-12-03"></event><event type="xmlCreated" agent="Aptara" date="2013-10-18"></event><event type="firstOnline" date="2013-11-14"></event><event type="publishedOnlineFinalForm" date="2013-11-14"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">129</numbering><numbering type="pageLast">138</numbering></numberingGroup><linkGroup><link type="toTypesetVersion" href="file://MIM.MIM00162.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Characterization of Cells Infiltrating the Lungs of X‐Irradiated and Nude Mice after Influenza Virus Infection</title></titleGroup><creators><creator xml:id="mim00162-cr-0001" creatorRole="author" affiliationRef="#mim00162-aff-0001" corresponding="no"><personName><givenNames>Emiko</givenNames><familyName>Shimomura</familyName></personName></creator><creator xml:id="mim00162-cr-0002" creatorRole="author" affiliationRef="#mim00162-aff-0001" corresponding="no"><personName><givenNames>Fujio</givenNames><familyName>Suzuki</familyName></personName></creator><creator xml:id="mim00162-cr-0003" creatorRole="author" affiliationRef="#mim00162-aff-0001" corresponding="no"><personName><givenNames>Nakao</givenNames><familyName>Ishida</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="mim00162-aff-0001" type="organization" countryCode="JP"><orgDiv>Department of Bacteriology</orgDiv><orgName>Tohoku University School of Medicine</orgName><address><city>Seiryo‐machi</city><countryPart>Sendai, Miyagi</countryPart><postCode>980</postCode></address></affiliation></affiliationGroup><fundingInfo><fundingAgency>Ministry of Education, Science and Culture of Japan</fundingAgency></fundingInfo><fundingInfo><fundingAgency>The Sendai Institute of Microbiology</fundingAgency></fundingInfo><abstractGroup><abstract type="main"><title type="main">Abstract</title><p>After X‐irradiated and nonirradiated mice (C3H/He) as well as athymic nude mice and haired littermates (BALB/c) were infected with influenza A virus (Kumamoto strain, H2N2), they were examined for survival period, the development of consolidation in the lungs and the characteristics of the cells infiltrating the lung tissues. In two different T‐cell deficient groups, there was a definite delay in the development of consolidation compared with their respective controls and this was reflected in prolonged survival periods: 5 days longer for irradiated mice and 6 days longer for nude mice. In both T‐cell deficient and normal groups, about 70% of the cells obtained from consolidated lung tissues after virus infection were found to be small lymphoid cells and there were no morphological differences between the T‐cell deficient and normal groups. None of these small lymphoid cells from the peripheral blood or the spleens of T‐cell deficient mice responded to concanavalin A. In the lungs of both X‐irradiated mice and nude mice, however, a definite increase in cells having natural killer activity was found at the late stages of the influenza infection, suggesting their participation in the development of consolidation.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Characterization of Cells Infiltrating the Lungs of X‐Irradiated and Nude Mice after Influenza Virus Infection</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Characterization of Cells Infiltrating the Lungs of X‐Irradiated and Nude Mice after Influenza Virus Infection</title></titleInfo><name type="personal"><namePart type="given">Emiko</namePart><namePart type="family">Shimomura</namePart><affiliation>Department of Bacteriology, Tohoku University School of Medicine, Sendai, Miyagi, 980, Seiryo‐machi</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fujio</namePart><namePart type="family">Suzuki</namePart><affiliation>Department of Bacteriology, Tohoku University School of Medicine, Sendai, Miyagi, 980, Seiryo‐machi</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nakao</namePart><namePart type="family">Ishida</namePart><affiliation>Department of Bacteriology, Tohoku University School of Medicine, Sendai, Miyagi, 980, Seiryo‐machi</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">1982-02</dateIssued><dateCreated encoding="w3cdtf">2013-10-18</dateCreated><dateCaptured encoding="w3cdtf">1981-08-08</dateCaptured><dateValid encoding="w3cdtf">1981-12-03</dateValid><copyrightDate encoding="w3cdtf">1982</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>After X‐irradiated and nonirradiated mice (C3H/He) as well as athymic nude mice and haired littermates (BALB/c) were infected with influenza A virus (Kumamoto strain, H2N2), they were examined for survival period, the development of consolidation in the lungs and the characteristics of the cells infiltrating the lung tissues. In two different T‐cell deficient groups, there was a definite delay in the development of consolidation compared with their respective controls and this was reflected in prolonged survival periods: 5 days longer for irradiated mice and 6 days longer for nude mice. In both T‐cell deficient and normal groups, about 70% of the cells obtained from consolidated lung tissues after virus infection were found to be small lymphoid cells and there were no morphological differences between the T‐cell deficient and normal groups. None of these small lymphoid cells from the peripheral blood or the spleens of T‐cell deficient mice responded to concanavalin A. 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